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Peer-reviewedCC BY 4.0Frontiers in Immunology

Small elements, huge impact: the role of micronutrients in pemphigus

  • Hong-mei Chang1,2
  • Xue Wang1,2
  • Juan Du1,2
  • Wei-long Zhang1,2
  1. 1Department of Oral and Maxillofacial Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University
  2. 2School of Stomatology, Shandong First Medical University
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Abstract

Pemphigus is an autoimmune blistering disease affecting both the skin and mucous membranes, causing secondary infections and high mortality. Micronutrients are important factors influencing the health of oral mucosa. It has been reported that patients with pemphigus have reduced levels of vitamins A, B3, D, copper, iron, selenium, and antioxidants. However, the specific mechanistic role of micronutrients in the initiation and progression of pemphigus remains poorly characterized. This review presents a detailed exploration of the relationship between pemphigus and micronutrient levels, seeking to unravel the mechanistic basis of micronutrients’ effects on pemphigus pathogenesis and to discuss their prospective applications in the disease’s prevention and therapy.

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Cite

BibTeXRIS
BibTeX
@article{chang2026small,
  title = {{Small elements, huge impact: the role of micronutrients in pemphigus}},
  author = {Hong-mei Chang and Xue Wang and Juan Du and Wei-long Zhang},
  journal = {Frontiers in Immunology},
  year = {2026},
  month = oct,
  doi = {10.3389/fimmu.2026.1980495},
  url = {https://www.frontiersin.org/articles/10.3389/fimmu.2026.1980495/full},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Small elements, huge impact: the role of micronutrients in pemphigus
AU  - Hong-mei Chang
AU  - Xue Wang
AU  - Juan Du
AU  - Wei-long Zhang
PY  - 2026
DA  - 2026/10/08
JO  - Frontiers in Immunology
DO  - 10.3389/fimmu.2026.1980495
UR  - https://www.frontiersin.org/articles/10.3389/fimmu.2026.1980495/full
AB  - Pemphigus is an autoimmune blistering disease affecting both the skin and mucous membranes, causing secondary infections and high mortality. Micronutrients are important factors influencing the health of oral mucosa. It has been reported that patients with pemphigus have reduced levels of vitamins A, B3, D, copper, iron, selenium, and antioxidants. However, the specific mechanistic role of micronutrients in the initiation and progression of pemphigus remains poorly characterized. This review presents a detailed exploration of the relationship between pemphigus and micronutrient levels, seeking to unravel the mechanistic basis of micronutrients’ effects on pemphigus pathogenesis and to discuss their prospective applications in the disease’s prevention and therapy.
SN  - 1664-3224
ER  -