A bibliometric analysis of Piezo2 channel research
5 affiliations
- 1Clinical Medical College of Acupuncture Moxibustion and Rehabilitation, Guangzhou University of Chinese Medicine, Guangzhou, 510006, China
- 2The First Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, 510006, China
- 3Graduate School of Guangzhou University of Chinese Medicine, Guangzhou, 510006, China
- 4School of Traditional Chinese Medicine, Ningxia Medical University, Yinchuan, 750004, China
- 5School of Public Health and Management, Guangzhou University of Chinese Medicine, Guangzhou, 510006, China
Abstract
Background: As a pivotal mechanosensitive ion channel, Piezo2 has maintained robust research momentum over the past decade. Drawing on comprehensive bibliometric evidence, this study systematically synthesizes recent breakthroughs, prevailing controversies, and future trajectories in the field.
Methods: We retrieved Piezo2-related publications from 2010 to 2026 from the Web of Science Core Collection (WOSCC), and conducted visual bibliometric analyses via CiteSpace, VOSviewer, and Biblioshiny to characterize publication output, collaboration networks, co-citation structures, and keyword bursts.
Results: This bibliometric analysis (2010–2026) reveals a triphasic evolution of Piezo2 research: Piezo2 publication output increased progressively, from a nascent stage of fewer than 20 papers per year prior to 2016, through accelerated growth that coincided with the increased research interest following the 2021 Nobel Prize, culminating in a peak of approximately 110 papers in 2025—although bibliometric trends alone cannot establish a causal effect of the Prize on this growth. The field, anchored by Patapoutian, features divergent US-China-Europe collaborations. Co-citation highlights Coste et al.'s 2010 foundational work, while keyword bursts signal a shift from neuroscience to systemic pathophysiology. Research is transitioning to translational network regulation, heralding precision intervention.
Conclusions: Bibliometric analysis confirms Piezo2 as a sustained hotspot pioneered by Patapoutian/Coste et al. US-China-Europe collaborations have driven its paradigm shift from channel characterization to multi-system regulation, foreshadowing precision therapies for pain and visceral diseases. Future work should dissect its molecular mechanisms, map interactome networks, and track clinical progress in Piezo2-linked neurological, reproductive, and surgical disorders.
Related
- Smart Agriculture Research in Date Palm (Phoenix dactylifera L.) Production: A Comprehensive Bibliometric Study
- Edible Insects for Future Protein and Product Development: Mapping Global Research Trends, Innovation, and Development Through Bibliometric Analysis
- Plant Disease and Phytopathogen Research in Central Asia: A Bibliometric Mapping of Research Trends, Collaboration, and Emerging Directions
- Mapping Brain-Computer Interface Research in Depression (1995-2026): A Bibliometric Analysis.
- Digital health meets Parkinson's disease: a bibliometric exploration of wearable sensors research and emerging frontiers (2005-2026).
BibTeX
@article{zhang2026bibliometric,
title = {{A bibliometric analysis of Piezo2 channel research}},
author = {Wenwen Zhang and Siyun Chen and Shumin Lin and Guannan Cheng and Wenqing Peng and Zining Guo and Lin Wang and Jian Sun and Nenggui Xu and Bin Guo and Bingqing Jiao and Xiaorong Tang},
journal = {IBRO Neuroscience Reports},
year = {2026},
month = oct,
doi = {10.1016/j.ibneur.2026.10.007},
url = {https://doi.org/10.1016/j.ibneur.2026.10.007},
note = {CC BY-NC-ND 4.0},
}
RIS
TY - JOUR
TI - A bibliometric analysis of Piezo2 channel research
AU - Wenwen Zhang
AU - Siyun Chen
AU - Shumin Lin
AU - Guannan Cheng
AU - Wenqing Peng
AU - Zining Guo
AU - Lin Wang
AU - Jian Sun
AU - Nenggui Xu
AU - Bin Guo
AU - Bingqing Jiao
AU - Xiaorong Tang
PY - 2026
DA - 2026/10/21
JO - IBRO Neuroscience Reports
DO - 10.1016/j.ibneur.2026.10.007
UR - https://doi.org/10.1016/j.ibneur.2026.10.007
AB - Background: As a pivotal mechanosensitive ion channel, Piezo2 has maintained robust research momentum over the past decade. Drawing on comprehensive bibliometric evidence, this study systematically synthesizes recent breakthroughs, prevailing controversies, and future trajectories in the field. Methods: We retrieved Piezo2-related publications from 2010 to 2026 from the Web of Science Core Collection (WOSCC), and conducted visual bibliometric analyses via CiteSpace, VOSviewer, and Biblioshiny to characterize publication output, collaboration networks, co-citation structures, and keyword bursts. Results: This bibliometric analysis (2010–2026) reveals a triphasic evolution of Piezo2 research: Piezo2 publication output increased progressively, from a nascent stage of fewer than 20 papers per year prior to 2016, through accelerated growth that coincided with the increased research interest following the 2021 Nobel Prize, culminating in a peak of approximately 110 papers in 2025—although bibliometric trends alone cannot establish a causal effect of the Prize on this growth. The field, anchored by Patapoutian, features divergent US-China-Europe collaborations. Co-citation highlights Coste et al.'s 2010 foundational work, while keyword bursts signal a shift from neuroscience to systemic pathophysiology. Research is transitioning to translational network regulation, heralding precision intervention. Conclusions: Bibliometric analysis confirms Piezo2 as a sustained hotspot pioneered by Patapoutian/Coste et al. US-China-Europe collaborations have driven its paradigm shift from channel characterization to multi-system regulation, foreshadowing precision therapies for pain and visceral diseases. Future work should dissect its molecular mechanisms, map interactome networks, and track clinical progress in Piezo2-linked neurological, reproductive, and surgical disorders.
SN - 2667-2421
ER -