Peer-reviewedCC BYIJID regions2 Oct 2026

Epidemiology, clinical characteristics, and outcomes of infective endocarditis over a decade in a tertiary care hospital in Oman.

Nasma Abdullah Al Sakiti¹
Ala Al-Lawati²
Sachin Jose³
Kawther Al Bahrani⁴
Faryal Khamis¹

4 affiliations

¹Department of Infectious Diseases, The Royal Hospital, Muscat, Oman.
²Department of Cardio-thoracic Surgery, The Royal Hospital, Muscat, Oman.
³Research Department, Oman Medical Specialty Board, Muscat, Oman.
⁴School of Medical Sciences, University of Manchester, Manchester, UK.

Abstract

Objectives

Infective endocarditis (IE) remains associated with substantial morbidity and mortality, although data from Oman and the Gulf region are limited. We aimed to describe the epidemiology, clinical characteristics, microbiological profile, and in-hospital outcomes of definite IE in a tertiary care hospital in Oman.Methods

We conducted a retrospective cohort study of patients admitted between 2006 and 2016. Cases were identified from electronic medical records using the International Classification of Diseases, Tenth Revision, Clinical Modification code I33.0. The modified Duke criteria were applied retrospectively and only definite IE cases were included.Results

Among 172 screened patients, 130 (75.6%) met the criteria for definite IE. The mean age was 42.3 years, and the median symptom duration before diagnosis was 14 days. Native valve IE occurred in 113 (87.0%) patients and prosthetic valve IE occurred in 17 (13.0%). Staphylococcus species were the most commonly isolated pathogens (43.1%), among which Staphylococcus aureus accounted for 38.5%. In-hospital mortality was 31.5%, and mortality was lower in patients who underwent surgery than in those who did not (18.0% vs 40.0%; P = 0.011).Conclusion

In this Omani cohort, IE affected a relatively young population and was characterized by predominant S. aureus infection and high in-hospital mortality. These findings support context-specific empiric therapy, early echocardiographic evaluation, and timely surgical assessment.

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BibTeX RIS

BibTeX

@article{sakiti2026epidemiology,
  title = {{Epidemiology, clinical characteristics, and outcomes of infective endocarditis over a decade in a tertiary care hospital in Oman.}},
  author = {Nasma Abdullah Al Sakiti and Ala Al-Lawati and Sachin Jose and Kawther Al Bahrani and Faryal Khamis},
  journal = {IJID regions},
  year = {2026},
  month = oct,
  doi = {10.1016/j.ijregi.2026.101033},
  url = {https://europepmc.org/article/MED/42926847},
  note = {CC BY},
}

RIS

TY  - JOUR
TI  - Epidemiology, clinical characteristics, and outcomes of infective endocarditis over a decade in a tertiary care hospital in Oman.
AU  - Nasma Abdullah Al Sakiti
AU  - Ala Al-Lawati
AU  - Sachin Jose
AU  - Kawther Al Bahrani
AU  - Faryal Khamis
PY  - 2026
DA  - 2026/10/02
JO  - IJID regions
DO  - 10.1016/j.ijregi.2026.101033
UR  - https://europepmc.org/article/MED/42926847
AB  - Objectives  Infective endocarditis (IE) remains associated with substantial morbidity and mortality, although data from Oman and the Gulf region are limited. We aimed to describe the epidemiology, clinical characteristics, microbiological profile, and in-hospital outcomes of definite IE in a tertiary care hospital in Oman.Methods  We conducted a retrospective cohort study of patients admitted between 2006 and 2016. Cases were identified from electronic medical records using the International Classification of Diseases, Tenth Revision, Clinical Modification code I33.0. The modified Duke criteria were applied retrospectively and only definite IE cases were included.Results  Among 172 screened patients, 130 (75.6%) met the criteria for definite IE. The mean age was 42.3 years, and the median symptom duration before diagnosis was 14 days. Native valve IE occurred in 113 (87.0%) patients and prosthetic valve IE occurred in 17 (13.0%). Staphylococcus species were the most commonly isolated pathogens (43.1%), among which Staphylococcus aureus accounted for 38.5%. In-hospital mortality was 31.5%, and mortality was lower in patients who underwent surgery than in those who did not (18.0% vs 40.0%; P = 0.011).Conclusion  In this Omani cohort, IE affected a relatively young population and was characterized by predominant S. aureus infection and high in-hospital mortality. These findings support context-specific empiric therapy, early echocardiographic evaluation, and timely surgical assessment.
SN  - 2772-7076
ER  -

Abstract

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