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PreprintCC BY-NC-ND 4.0HAL

Dishevelled2 Condensates control Axon Initial Segment (AIS) assembly and function through MTCL1-Dependent microtubule recruitment

  • Sophie Belmonte
  • Sonia Poirault-Chassac
  • Juliette Villagomez
  • Charlotte Isch
  • Ana Dorrego-Rivas
  • Margot Donier
  • Emilie Chagny
  • Ellyn Renou
  • Louis Vacher
  • Nathalie Aubailly
  • Maïté Marie Moreau
  • Melissa David
6 more authors
  • Magali Mondin
  • Mireille Montcouquiol
  • Matthieu Sainlos
  • Arne Battefeld
  • Nathalie Sans
  • Jerome Ezan
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Abstract

Dvl2 is an early component of the proximal axon initial segment (AIS)

• Dvl2 associates with AIS microtubule bundles and depends on MTCL1 for microtubule recruitment

• Dvl depletion disrupts AIS cytoskeletal organization, AnkG accumulation, sodium channel clustering

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Cite

BibTeXRIS
BibTeX
@misc{belmonte2026dishevelled2,
  title = {{Dishevelled2 Condensates control Axon Initial Segment (AIS) assembly and function through MTCL1-Dependent microtubule recruitment}},
  author = {Sophie Belmonte and Sonia Poirault-Chassac and Juliette Villagomez and Charlotte Isch and Ana Dorrego-Rivas and Margot Donier and Emilie Chagny and Ellyn Renou and Louis Vacher and Nathalie Aubailly and Maïté Marie Moreau and Melissa David and Magali Mondin and Mireille Montcouquiol and Matthieu Sainlos and Arne Battefeld and Nathalie Sans and Jerome Ezan},
  howpublished = {HAL},
  year = {2026},
  month = oct,
  doi = {10.64898/2026.10.08.757526},
  url = {https://hal.science/hal-05839480v1},
  note = {CC BY-NC-ND 4.0},
}
RIS
TY  - UNPB
TI  - Dishevelled2 Condensates control Axon Initial Segment (AIS) assembly and function through MTCL1-Dependent microtubule recruitment
AU  - Sophie Belmonte
AU  - Sonia Poirault-Chassac
AU  - Juliette Villagomez
AU  - Charlotte Isch
AU  - Ana Dorrego-Rivas
AU  - Margot Donier
AU  - Emilie Chagny
AU  - Ellyn Renou
AU  - Louis Vacher
AU  - Nathalie Aubailly
AU  - Maïté Marie Moreau
AU  - Melissa David
AU  - Magali Mondin
AU  - Mireille Montcouquiol
AU  - Matthieu Sainlos
AU  - Arne Battefeld
AU  - Nathalie Sans
AU  - Jerome Ezan
PY  - 2026
DA  - 2026/10/08
PB  - HAL
DO  - 10.64898/2026.10.08.757526
UR  - https://hal.science/hal-05839480v1
AB  - Dvl2 is an early component of the proximal axon initial segment (AIS)  • Dvl2 associates with AIS microtubule bundles and depends on MTCL1 for microtubule recruitment  • Dvl depletion disrupts AIS cytoskeletal organization, AnkG accumulation, sodium channel clustering
ER  -