Estimating dose-response relationships for vitamin D with coronary heart disease, stroke, and all-cause mortality: observational and Mendelian randomisation analyses

@article{sofianopoulou2026estimating,
  title = {{Estimating dose-response relationships for vitamin D with coronary heart disease, stroke, and all-cause mortality: observational and Mendelian randomisation analyses}},
  author = {Eleni Sofianopoulou and Stephen Kaptoge and Shoaib Afzal and Tao Jiang and Dipender Gill and Thomas Gundersen and Thomas Bolton and Elias Allara and Matthew Arnold and Amy Mason and Ryan Chung and Lisa Pennells and Fanchao Shi and Luanluan Sun and Peter Willeit and Nita Forouhi and Claudia Langenberg and Stephen Sharp and Salvatore Panico and Gunnar Engström and Olle Melander and Tammy Tong and Aurora Perez-Cornago and Margareta Norberg and Ingegerd Johansson and Verena Katzke and Bernard Srour and María José Sánchez and Daniel Redondo-Sánchez and Anja Olsen and Christina Dahm and Kim Overvad and Magritt Brustad and Guri Skeie and Conchi Moreno-Iribas and N Charlotte Onland-Moret and Yvonne van der Schouw and Konstantinos Tsilidis and Alicia Heath and Claudia Agnoli and Vittorio Krogh and Ian de Boer and Camilla Jannie Kobylecki and Yunus Çolak and Armin Zittermann and Johan Sundström and Paul Welsh and Elisabete Weiderpass and Elom Aglago and Pietro Ferrari and Robert Clarke and Marie-Christine Boutron and Gianluca Severi and Conor Macdonald and Rui Providencia and Giovanna Masala and Raul Zamora Ros and Jolanda Boer and Wm Monique Verschuren and Peggy Cawthon},
  journal = {The Lancet. Diabetes \& Endocrinology},
  year = {2026},
  month = sep,
  doi = {10.1016/s2213-8587(23)00287-5},
  url = {https://hal.inrae.fr/hal-05630940v1},
  note = {CC BY 4.0},
}

TY  - JOUR
TI  - Estimating dose-response relationships for vitamin D with coronary heart disease, stroke, and all-cause mortality: observational and Mendelian randomisation analyses
AU  - Eleni Sofianopoulou
AU  - Stephen Kaptoge
AU  - Shoaib Afzal
AU  - Tao Jiang
AU  - Dipender Gill
AU  - Thomas Gundersen
AU  - Thomas Bolton
AU  - Elias Allara
AU  - Matthew Arnold
AU  - Amy Mason
AU  - Ryan Chung
AU  - Lisa Pennells
AU  - Fanchao Shi
AU  - Luanluan Sun
AU  - Peter Willeit
AU  - Nita Forouhi
AU  - Claudia Langenberg
AU  - Stephen Sharp
AU  - Salvatore Panico
AU  - Gunnar Engström
AU  - Olle Melander
AU  - Tammy Tong
AU  - Aurora Perez-Cornago
AU  - Margareta Norberg
AU  - Ingegerd Johansson
AU  - Verena Katzke
AU  - Bernard Srour
AU  - María José Sánchez
AU  - Daniel Redondo-Sánchez
AU  - Anja Olsen
AU  - Christina Dahm
AU  - Kim Overvad
AU  - Magritt Brustad
AU  - Guri Skeie
AU  - Conchi Moreno-Iribas
AU  - N Charlotte Onland-Moret
AU  - Yvonne van der Schouw
AU  - Konstantinos Tsilidis
AU  - Alicia Heath
AU  - Claudia Agnoli
AU  - Vittorio Krogh
AU  - Ian de Boer
AU  - Camilla Jannie Kobylecki
AU  - Yunus Çolak
AU  - Armin Zittermann
AU  - Johan Sundström
AU  - Paul Welsh
AU  - Elisabete Weiderpass
AU  - Elom Aglago
AU  - Pietro Ferrari
AU  - Robert Clarke
AU  - Marie-Christine Boutron
AU  - Gianluca Severi
AU  - Conor Macdonald
AU  - Rui Providencia
AU  - Giovanna Masala
AU  - Raul Zamora Ros
AU  - Jolanda Boer
AU  - Wm Monique Verschuren
AU  - Peggy Cawthon
PY  - 2026
DA  - 2026/09/03
JO  - The Lancet. Diabetes & Endocrinology
DO  - 10.1016/s2213-8587(23)00287-5
UR  - https://hal.inrae.fr/hal-05630940v1
AB  - Randomised trials of vitamin D supplementation for cardiovascular disease and all-cause mortality have generally reported null findings. However, generalisability of results to individuals with low vitamin D status is unclear. We aimed to characterise dose-response relationships between 25-hydroxyvitamin D (25[OH]D) concentrations and risk of coronary heart disease, stroke, and all-cause mortality in observational and Mendelian randomisation frameworks.
SN  - 2213-8587
SN  - 2213-8595
ER  -