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Peer-reviewedCC BYJournal of ophthalmology

Central Adiposity and Tear Film Instability in Adults With Obesity.

  • Ao Li1
  • Yifei Wu1
  • Rongteng Lin2
  • Yubo Wu2
  • Qian Nie3
  • Lei Tian1
  • Ying Jie1
  1. 1Beijing Institute of Ophthalmology Beijing Tongren Eye Center Beijing Tongren Hospital Beijing Ophthalmology & Visual Sciences Key Laboratory Capital Medical University Beijing 100730 China ccmu.edu.cn.
  2. 2School of Basic Medical Sciences Capital Medical University Beijing 100069 China ccmu.edu.cn.
  3. 3Physical Examination Center Hebei General Hospital Shijiazhuang 050051 China hebmu.edu.cn.
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Abstract

To examine the association between central adiposity, assessed by waist-to-height ratio (WHtR), and tear film stability in adults with obesity. This cross-sectional observational study included 269 adults with BMI ≥ 28 kg/m2. WHtR and noninvasive tear breakup time (NIBUT) were the primary exposure and outcome. Models adjusted for age, sex, education, systemic diseases, myopia, display exposure, smoking, alcohol consumption, and sleep problems. Secondary outcomes were Ocular Surface Disease Index (OSDI) and dry eye disease (DED) status; other adiposity indices were examined in separate models. Each 1-SD higher WHtR was associated with shorter NIBUT (adjusted β -0.341 s; 95% CI -0.612--0.071; p = 0.014). The highest versus lowest WHtR tertile differed by -0.961 s (95% CI -1.696--0.227). BMI had a numerically larger coefficient (-0.591 s; 95% CI -0.842--0.339). DED was present in 208 participants (77.3%). The WHtR-DED association was nominally significant (OR 1.630; 95% CI 1.072-2.477; p = 0.022) but did not survive false discovery rate correction (q = 0.061). Higher WHtR was associated with modestly shorter NIBUT among adults with obesity, while BMI showed a numerically larger association. These findings support considering overall and abdominal adiposity in the clinical assessment of ocular surface function.

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Cite

BibTeXRIS
BibTeX
@article{li2026central,
  title = {{Central Adiposity and Tear Film Instability in Adults With Obesity.}},
  author = {Ao Li and Yifei Wu and Rongteng Lin and Yubo Wu and Qian Nie and Lei Tian and Ying Jie},
  journal = {Journal of ophthalmology},
  year = {2026},
  month = nov,
  doi = {10.1155/joph/7742500},
  url = {https://europepmc.org/article/MED/42997162},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Central Adiposity and Tear Film Instability in Adults With Obesity.
AU  - Ao Li
AU  - Yifei Wu
AU  - Rongteng Lin
AU  - Yubo Wu
AU  - Qian Nie
AU  - Lei Tian
AU  - Ying Jie
PY  - 2026
DA  - 2026/11/06
JO  - Journal of ophthalmology
DO  - 10.1155/joph/7742500
UR  - https://europepmc.org/article/MED/42997162
AB  - To examine the association between central adiposity, assessed by waist-to-height ratio (WHtR), and tear film stability in adults with obesity. This cross-sectional observational study included 269 adults with BMI ≥ 28 kg/m2. WHtR and noninvasive tear breakup time (NIBUT) were the primary exposure and outcome. Models adjusted for age, sex, education, systemic diseases, myopia, display exposure, smoking, alcohol consumption, and sleep problems. Secondary outcomes were Ocular Surface Disease Index (OSDI) and dry eye disease (DED) status; other adiposity indices were examined in separate models. Each 1-SD higher WHtR was associated with shorter NIBUT (adjusted β -0.341 s; 95% CI -0.612--0.071; p = 0.014). The highest versus lowest WHtR tertile differed by -0.961 s (95% CI -1.696--0.227). BMI had a numerically larger coefficient (-0.591 s; 95% CI -0.842--0.339). DED was present in 208 participants (77.3%). The WHtR-DED association was nominally significant (OR 1.630; 95% CI 1.072-2.477; p = 0.022) but did not survive false discovery rate correction (q = 0.061). Higher WHtR was associated with modestly shorter NIBUT among adults with obesity, while BMI showed a numerically larger association. These findings support considering overall and abdominal adiposity in the clinical assessment of ocular surface function.
SN  - 2090-004X
SN  - 2090-0058
ER  -