Association between sexual dysfunction and symptom burden in women with Chronic Obstructive Pulmonary Disease
- 1Department of Chest Diseases, Şişli Hamidiye Etfal Training and Research Hospital, University of Health Sciences, Istanbul, Turkey
- 2Department of Urology, Şişli Hamidiye Etfal Training and Research Hospital, University of Health Sciences, Istanbul, Turkey
- 3Department of Obstetrics and Gynecology, Şişli Hamidiye Etfal Training and Research Hospital, University of Health Sciences, Istanbul, Turkey
Abstract
Objectives: To investigate sexual dysfunction as a clinically relevant but under-recognized manifestation of disease burden in women with COPD and to identify its clinical and psychological determinants. Study design: In this cross-sectional study, 100 consecutive women with stable COPD (mean age 57 ± 7 years) attending an outpatient chest clinic were enrolled. Main outcome measures: Participants underwent pulmonary function testing and completed the COPD Assessment Test (CAT), Modified Medical Research Council (mMRC) scale, Beck Depression Inventory, Short Form-36 (SF-36), Functional Assessment of Chronic Illness Therapy–Fatigue (FACIT-FS), and Female Sexual Function Index (FSFI). Results: Sexual dysfunction (FSFI ≤26.55) was more prevalent in patients with greater disease burden, particularly those in GOLD stage E, and was associated with significantly higher fatigue and depressive symptoms. FSFI scores showed a positive correlation with FACIT-FS and quality-of-life domains, and a negative correlation with depression scores (all p < 0.05). In multivariable analysis, fatigue was positively associated with FSFI scores, whereas depression and body mass index were negatively associated. Patients with more severe disease (GOLD E), comorbidities, and dyspnea during intercourse had lower FSFI scores, while those receiving triple therapy demonstrated higher scores. Conclusions: Sexual dysfunction was associated with greater symptom burden in women with COPD and was closely related to fatigue and depression. Assessment of sexual function may contribute to a more comprehensive evaluation of disease burden in clinical practice.
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BibTeX
@article{ozkarafakılı2026association,
title = {{Association between sexual dysfunction and symptom burden in women with Chronic Obstructive Pulmonary Disease}},
author = {Müfide Arzu Özkarafakılı and Cemil Kutsal and Nihat Türkmen and Hatice Yılmaz},
journal = {PLOS One},
year = {2026},
month = sep,
doi = {10.1371/journal.pone.0357921},
url = {https://doi.org/10.1371/journal.pone.0357921},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Association between sexual dysfunction and symptom burden in women with Chronic Obstructive Pulmonary Disease
AU - Müfide Arzu Özkarafakılı
AU - Cemil Kutsal
AU - Nihat Türkmen
AU - Hatice Yılmaz
PY - 2026
DA - 2026/09/15
JO - PLOS One
DO - 10.1371/journal.pone.0357921
UR - https://doi.org/10.1371/journal.pone.0357921
AB - Objectives: To investigate sexual dysfunction as a clinically relevant but under-recognized manifestation of disease burden in women with COPD and to identify its clinical and psychological determinants. Study design: In this cross-sectional study, 100 consecutive women with stable COPD (mean age 57 ± 7 years) attending an outpatient chest clinic were enrolled. Main outcome measures: Participants underwent pulmonary function testing and completed the COPD Assessment Test (CAT), Modified Medical Research Council (mMRC) scale, Beck Depression Inventory, Short Form-36 (SF-36), Functional Assessment of Chronic Illness Therapy–Fatigue (FACIT-FS), and Female Sexual Function Index (FSFI). Results: Sexual dysfunction (FSFI ≤26.55) was more prevalent in patients with greater disease burden, particularly those in GOLD stage E, and was associated with significantly higher fatigue and depressive symptoms. FSFI scores showed a positive correlation with FACIT-FS and quality-of-life domains, and a negative correlation with depression scores (all p < 0.05). In multivariable analysis, fatigue was positively associated with FSFI scores, whereas depression and body mass index were negatively associated. Patients with more severe disease (GOLD E), comorbidities, and dyspnea during intercourse had lower FSFI scores, while those receiving triple therapy demonstrated higher scores. Conclusions: Sexual dysfunction was associated with greater symptom burden in women with COPD and was closely related to fatigue and depression. Assessment of sexual function may contribute to a more comprehensive evaluation of disease burden in clinical practice.
SN - 1932-6203
ER -