Association of HER2, p53, and lymphovascular space invasion with lymph node metastasis in endometrial cancer: a retrospective cohort study
- 1Faculty of Medicine, Yangzhou University, Yangzhou, Jiangsu, China
- 2Department of Obstetrics and Gynecology, Northern Jiangsu People’s Hospital Affiliated to Yangzhou University, Yangzhou, Jiangsu, China
- 3Department of Obstetrics and Gynecology, Northern Jiangsu People’s Hospital, Yangzhou, Jiangsu, China
Abstract
Background: The assessment of lymph node metastasis (LNM) in endometrial carcinoma is critical for optimizing the extent of surgical resection and formulating individualized therapies. This study aimed to investigate the associated factors of the LNM in endometrial carcinoma.
Methods: 438 patients with endometrial carcinoma who underwent primary surgical staging between June 2014 and June 2025 were retrospectively analyzed. Clinicopathological data and immunohistochemical expression profiles of ER, PR, HER2, p53, Ki67, ERCC1, and GST-π were systematically collected. Univariate and multivariate logistic regression analyses were performed to identify independent associated factors for LNM.
Results: The overall incidence of LNM in the study was 10.27% (45/438). Univariate analysis revealed that menopausal status, histological grade, Bokhman pathological subtype, depth of myometrial invasion, lymphovascular space invasion (LVSI), and the expression levels of ER, PR, Ki67, p53, and HER2 were significantly associated with LNM (all P < 0.05). Subsequent multivariate analysis identified each one-category increase in HER2 staining level was associated with higher odds of LNM (OR 3.859, 95% CI 2.314–6.436, P < 0.001), as was each one-category increase in p53 staining level (OR 1.932, 95% CI 1.212–3.082, P = 0.006). The presence of LVSI was also an independent associated factor for LNM.
Conclusions: Higher p53 and HER2 staining levels and the presence of LVSI are independently associated with LNM in endometrial carcinoma.
Related
- Limited-site adaptation reveals representation-specific MRI transportability for lymphovascular invasion in endometrial cancer
- Investigating the potential association between the continuous-time random-walk MR diffusion model and lymph node metastasis and vascular invasion in patients with rectal cancer: A preliminary exploratory study
- Integrating Systemic Inflammation, Nutrition and Skeletal Muscle into a Composite Score (the HALP–Sarcopenia Combined Index) for Preoperative Risk Stratification of Lymph-Node Metastasis and Recurrence in Endometrial Carcinoma: A Single-Centre Retrospective Study
- Explosive cervical lymph node recurrence following two-field lymphadenectomy in pT1b (SM2) middle esophageal squamous cell carcinoma with INFb pattern and absent lymphovascular invasion: a case report
- Association Between Tumor Budding and Lymph Node Metastasis in Surgically Resected Colon Cancer: A Retrospective Observational Study
BibTeX
@article{cai2026association,
title = {{Association of HER2, p53, and lymphovascular space invasion with lymph node metastasis in endometrial cancer: a retrospective cohort study}},
author = {Xuqing Cai and Yuanyuan Zhu and Siying Wang and Lingling Gao and Dan Lu},
journal = {Frontiers in Oncology},
year = {2026},
month = oct,
doi = {10.3389/fonc.2026.1974528},
url = {https://doi.org/10.3389/fonc.2026.1974528},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Association of HER2, p53, and lymphovascular space invasion with lymph node metastasis in endometrial cancer: a retrospective cohort study
AU - Xuqing Cai
AU - Yuanyuan Zhu
AU - Siying Wang
AU - Lingling Gao
AU - Dan Lu
PY - 2026
DA - 2026/10/12
JO - Frontiers in Oncology
DO - 10.3389/fonc.2026.1974528
UR - https://doi.org/10.3389/fonc.2026.1974528
AB - Background: The assessment of lymph node metastasis (LNM) in endometrial carcinoma is critical for optimizing the extent of surgical resection and formulating individualized therapies. This study aimed to investigate the associated factors of the LNM in endometrial carcinoma. Methods: 438 patients with endometrial carcinoma who underwent primary surgical staging between June 2014 and June 2025 were retrospectively analyzed. Clinicopathological data and immunohistochemical expression profiles of ER, PR, HER2, p53, Ki67, ERCC1, and GST-π were systematically collected. Univariate and multivariate logistic regression analyses were performed to identify independent associated factors for LNM. Results: The overall incidence of LNM in the study was 10.27% (45/438). Univariate analysis revealed that menopausal status, histological grade, Bokhman pathological subtype, depth of myometrial invasion, lymphovascular space invasion (LVSI), and the expression levels of ER, PR, Ki67, p53, and HER2 were significantly associated with LNM (all P < 0.05). Subsequent multivariate analysis identified each one-category increase in HER2 staining level was associated with higher odds of LNM (OR 3.859, 95% CI 2.314–6.436, P < 0.001), as was each one-category increase in p53 staining level (OR 1.932, 95% CI 1.212–3.082, P = 0.006). The presence of LVSI was also an independent associated factor for LNM. Conclusions: Higher p53 and HER2 staining levels and the presence of LVSI are independently associated with LNM in endometrial carcinoma.
SN - 2234-943X
ER -