Effectiveness of recruitment methods in cancer clinical trials: an Australian experience.
6 affiliations
- 1Faculty of Health, University of Technology Sydney, Ultimo, NSW, 2007, Australia. [email protected].
- 2Faculty of Health, University of Technology Sydney, Ultimo, NSW, 2007, Australia.
- 3University of Notre Dame Australia, School of Education, Broadway, NSW, 2007, Australia.
- 4Australian Institute of Technology and Commerce, Haymarket, NSW, 2000, Australia.
- 5Faculty of Medicine, University of Notre Dame Australia, Darlinghurst, NSW, 2010, Australia.
- 6Icon Cancer Centre, Sydney Adventist Hospital, Wahroonga, NSW, 2076, Australia.
Abstract
Objectives
High-quality clinical research relies on the adequate recruitment of trial participants. The success of this underpins Evidence-Based Medicine. Trials participation is recommended however few patients have the opportunity to participate. The purpose of this study was to evaluate completed trials with the same sponsor to identify, define and evaluate various sponsor-led methods that can be applied to improve recruitment.Methods
Building upon the Theories of Evidence-Based Medicine and Implementation Research, this study evaluated published data with the same Australian academic trial sponsor to identify, define and evaluate recruitment methods used in completed trials. Methods were ranked using a novel scale. Ethical and patient activation timeliness were considered. Data was extracted and tabulated (grouped, deidentified). Using descriptive statistics, a multi-disciplinary team synthesised and interpreted the data.Results
Between 2008-2020, 56 trials sponsored by the Australian skin cancer network were screened; three studies met the criteria. We identified, described and ranked four recruitment methods (Trial design, Trial promotion, education and training, Site selection and feasibility, Trial resourcing and incentivization, supported by 27 specific initiatives). Timely ethics administration was shown to be important. Despite some methods being more effortful than others, all methods contributed patients. There are a number of study limitations.Conclusions
Clinical trials are complex to run. Insufficient accrual is commonplace, including for Australian skin cancer trials. Four distinct recruitment methods with examples were identified. The results of this study may help trial sponsors and any other researcher to improve trial recruitment and completion, as well as patient outcomes.
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BibTeX
@article{paton2026effectiveness,
title = {{Effectiveness of recruitment methods in cancer clinical trials: an Australian experience.}},
author = {Elizabeth J Paton and Anthony G Shannon and Gerald B Fogarty},
journal = {BMC medical research methodology},
year = {2026},
month = aug,
doi = {10.1186/s12874-026-02948-4},
url = {https://europepmc.org/article/MED/42958075},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - Effectiveness of recruitment methods in cancer clinical trials: an Australian experience.
AU - Elizabeth J Paton
AU - Anthony G Shannon
AU - Gerald B Fogarty
PY - 2026
DA - 2026/08/03
JO - BMC medical research methodology
DO - 10.1186/s12874-026-02948-4
UR - https://europepmc.org/article/MED/42958075
AB - Objectives High-quality clinical research relies on the adequate recruitment of trial participants. The success of this underpins Evidence-Based Medicine. Trials participation is recommended however few patients have the opportunity to participate. The purpose of this study was to evaluate completed trials with the same sponsor to identify, define and evaluate various sponsor-led methods that can be applied to improve recruitment.Methods Building upon the Theories of Evidence-Based Medicine and Implementation Research, this study evaluated published data with the same Australian academic trial sponsor to identify, define and evaluate recruitment methods used in completed trials. Methods were ranked using a novel scale. Ethical and patient activation timeliness were considered. Data was extracted and tabulated (grouped, deidentified). Using descriptive statistics, a multi-disciplinary team synthesised and interpreted the data.Results Between 2008-2020, 56 trials sponsored by the Australian skin cancer network were screened; three studies met the criteria. We identified, described and ranked four recruitment methods (Trial design, Trial promotion, education and training, Site selection and feasibility, Trial resourcing and incentivization, supported by 27 specific initiatives). Timely ethics administration was shown to be important. Despite some methods being more effortful than others, all methods contributed patients. There are a number of study limitations.Conclusions Clinical trials are complex to run. Insufficient accrual is commonplace, including for Australian skin cancer trials. Four distinct recruitment methods with examples were identified. The results of this study may help trial sponsors and any other researcher to improve trial recruitment and completion, as well as patient outcomes.
SN - 1471-2288
ER -