Genotype Distribution Characteristics and Short-Term Follow-Up of HPV Infection Among Male Outpatients in Wenzhou, China.
- 1Department of Clinical Laboratory, Wenzhou People's Hospital, Wenzhou 325041, China.
- 2Department of Reproductive Medicine, Wenzhou Maternal and Child Health Hospital, Wenzhou 325000, China.
- 3Department of Disease Control and Prevention, Wenzhou Lucheng Center for Disease Control and Prevention, Wenzhou 325007, China.
Abstract
Objective
The aim of this study was to investigate the genotype distribution, co-infection patterns, and disease-specific characteristics of human papillomavirus (HPV) infection among male outpatients in Wenzhou, China.Methods
A total of 1934 male outpatients who underwent HPV genotyping at Wenzhou People's Hospital and Wenzhou Maternal and Child Health Hospital between April 2023 and March 2026 were enrolled. Baseline infection status, clinical manifestations, genotype co-infection patterns, and six-month follow-up outcomes were analyzed.Results
The overall HPV positivity rate was 39.14%. HPV52 was the most prevalent high-risk genotype (13.61%, 95% CI: 11.12-16.43%), most frequently co-detected with HPV51 and HPV58, whereas HPV6 dominated low-risk genotypes (40.16%, 95% CI: 36.69-43.66%). HPV positivity differed significantly across disease groups (p < 0.001), with the highest rate observed in mucocutaneous lesions (58.07%, 95% CI: 53.89-62.18%). Single-genotype infection predominated (73.71%, 95% CI: 70.58-76.85%). Of 757 HPV-positive patients, 403 (53.24%) completed six-month follow-up, and their rates of complete clearance, isolated persistence, incident-only genotype, and superinfection were 52.61%, 28.04%, 13.40%, and 5.96%, respectively.Conclusions
These findings underscore the need for male-specific HPV screening strategies, targeted health education for high-risk populations, and age-stratified individualized follow-up protocols. Such regional epidemiological evidence may help optimize local prevention, intervention, and clinical management of HPV-associated disorders in men.
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BibTeX
@article{dai2026genotype,
title = {{Genotype Distribution Characteristics and Short-Term Follow-Up of HPV Infection Among Male Outpatients in Wenzhou, China.}},
author = {Xianning Dai and Chenhui Zhang and Xi Xu and Kai Xu and Zitong Qian and Xi Chen},
journal = {Infectious disease reports},
year = {2026},
month = oct,
doi = {10.3390/idr18050116},
url = {https://europepmc.org/article/MED/42930507},
note = {CC BY},
}
RIS
TY - JOUR
TI - Genotype Distribution Characteristics and Short-Term Follow-Up of HPV Infection Among Male Outpatients in Wenzhou, China.
AU - Xianning Dai
AU - Chenhui Zhang
AU - Xi Xu
AU - Kai Xu
AU - Zitong Qian
AU - Xi Chen
PY - 2026
DA - 2026/10/08
JO - Infectious disease reports
DO - 10.3390/idr18050116
UR - https://europepmc.org/article/MED/42930507
AB - Objective The aim of this study was to investigate the genotype distribution, co-infection patterns, and disease-specific characteristics of human papillomavirus (HPV) infection among male outpatients in Wenzhou, China.Methods A total of 1934 male outpatients who underwent HPV genotyping at Wenzhou People's Hospital and Wenzhou Maternal and Child Health Hospital between April 2023 and March 2026 were enrolled. Baseline infection status, clinical manifestations, genotype co-infection patterns, and six-month follow-up outcomes were analyzed.Results The overall HPV positivity rate was 39.14%. HPV52 was the most prevalent high-risk genotype (13.61%, 95% CI: 11.12-16.43%), most frequently co-detected with HPV51 and HPV58, whereas HPV6 dominated low-risk genotypes (40.16%, 95% CI: 36.69-43.66%). HPV positivity differed significantly across disease groups (p < 0.001), with the highest rate observed in mucocutaneous lesions (58.07%, 95% CI: 53.89-62.18%). Single-genotype infection predominated (73.71%, 95% CI: 70.58-76.85%). Of 757 HPV-positive patients, 403 (53.24%) completed six-month follow-up, and their rates of complete clearance, isolated persistence, incident-only genotype, and superinfection were 52.61%, 28.04%, 13.40%, and 5.96%, respectively.Conclusions These findings underscore the need for male-specific HPV screening strategies, targeted health education for high-risk populations, and age-stratified individualized follow-up protocols. Such regional epidemiological evidence may help optimize local prevention, intervention, and clinical management of HPV-associated disorders in men.
SN - 2036-7430
SN - 2036-7449
ER -