Optimizing Lavandula mairei-mediated silver nanoparticle synthesis for effective inhibition and eradication of multidrug-resistant bacterial biofilms
Abstract
Multi-resistant bacteria represent a significant public health threat, due to their resistance to many antibiotics and their biofilm formation capacity, which are difficult to treat and often lead to prolonged illness. Silver nanoparticles are promising antimicrobial agents, penetrating biofilms and serving as potential antimicrobial agents against multi-drug resistant bacteria. This study focuses on optimizing the silver nanoparticle synthesis based on the extract of Lavandula mairei. The effects of silver nitrate concentration, extract volume, reaction time and temperature were investigated. In addition, the nanoparticles were characterized by UV-vis spectroscopy, Xray diffraction, scanning electron microscopy, energy dispersive X-ray spectroscopy, Fourier transform infrared spectroscopy, and dynamic light analysis. The synthesized nanoparticles were subsequently evaluated for inhibiting and eradicating biofilms formed by multi-resistant strains including Acinetobacter baumannii and ESBLproducing and non-ESBL-producing Enterobacteriaceae. Silver nanoparticles were successfully synthesized,
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BibTeX
@article{megdar2026optimizing,
title = {{Optimizing Lavandula mairei-mediated silver nanoparticle synthesis for effective inhibition and eradication of multidrug-resistant bacterial biofilms}},
author = {Soufiane El Megdar and Asma Laktib and Raja Elkheloui and Hicham Abou Oualid and Camelia Filofteia Diguţă and Florentina Matei and Sophie C Gangloff and Fany Reffuveille and Fouad Msanda and Mohamed Hassi and Fatima Hamadi},
journal = {Colloids and Surfaces A: Physicochemical and Engineering Aspects},
year = {2026},
month = oct,
doi = {10.1016/j.colsurfa.2025.136544},
url = {https://univ-reims.hal.science/hal-05765778v1},
note = {CC BY-NC-ND 4.0},
}
RIS
TY - JOUR
TI - Optimizing Lavandula mairei-mediated silver nanoparticle synthesis for effective inhibition and eradication of multidrug-resistant bacterial biofilms
AU - Soufiane El Megdar
AU - Asma Laktib
AU - Raja Elkheloui
AU - Hicham Abou Oualid
AU - Camelia Filofteia Diguţă
AU - Florentina Matei
AU - Sophie C Gangloff
AU - Fany Reffuveille
AU - Fouad Msanda
AU - Mohamed Hassi
AU - Fatima Hamadi
PY - 2026
DA - 2026/10/15
JO - Colloids and Surfaces A: Physicochemical and Engineering Aspects
DO - 10.1016/j.colsurfa.2025.136544
UR - https://univ-reims.hal.science/hal-05765778v1
AB - Multi-resistant bacteria represent a significant public health threat, due to their resistance to many antibiotics and their biofilm formation capacity, which are difficult to treat and often lead to prolonged illness. Silver nanoparticles are promising antimicrobial agents, penetrating biofilms and serving as potential antimicrobial agents against multi-drug resistant bacteria. This study focuses on optimizing the silver nanoparticle synthesis based on the extract of Lavandula mairei. The effects of silver nitrate concentration, extract volume, reaction time and temperature were investigated. In addition, the nanoparticles were characterized by UV-vis spectroscopy, Xray diffraction, scanning electron microscopy, energy dispersive X-ray spectroscopy, Fourier transform infrared spectroscopy, and dynamic light analysis. The synthesized nanoparticles were subsequently evaluated for inhibiting and eradicating biofilms formed by multi-resistant strains including Acinetobacter baumannii and ESBLproducing and non-ESBL-producing Enterobacteriaceae. Silver nanoparticles were successfully synthesized,
SN - 0927-7757
SN - 1873-4359
ER -