Frequent Versus Single Active Bouts Differentially Affect Movement Behavior and Energy Balance in Adults With Overweight/Obesity
5 affiliations
- 1Division of Endocrinology, Metabolism and Diabetes, Anschutz Health and Wellness Center, Department of Medicine, School of Medicine University of Colorado Anschutz Medical Campus Aurora Colorado USA
- 2Faculty of Applied Sciences State University of Campinas Limeira São Paulo Brazil
- 3Institut Pluridisciplinaire Hubert Curien, UMR7178 Centre National de la Recherche Scientifique, Université de Strasbourg Strasbourg France
- 4Section of Endocrinology, Department of Pediatrics, School of Medicine University of Colorado Anschutz Medical Campus Aurora Colorado USA
- 5CarMeN Laboratory INSERM 1060, INRA 1397, University Claude Bernard Lyon 1, Human Nutrition Research Center Rhône‐Alpes Oullins France
Abstract
OBJECTIVE: This study aimed to investigate the effects of breaking up sedentary behavior (SB) on daily movement behavior and energy balance in adults with overweight/obesity. METHODS: ) were randomized to either BREAK (multiple 5-min brisk walking bouts) or a duration-matched intervention, ONE (45-min brisk walking), performed 5 days/week for 6 weeks. At pre- and post-intervention, daily SB and physical activity (PA; accelerometry), body composition (doubly labeled water [DLW]), total daily energy expenditure (TDEE; DLW), appetite, and fasting leptin were measured. Linear mixed-effects models tested time effects and group-by-time interactions. RESULTS: Only BREAK reduced prolonged SB (interaction: p = 0.043). Both groups shifted SB-PA composition toward greater moderate-to-vigorous PA, with proportional reductions in SB and light PA (time: all p ≤ 0.011). These changes in PA level were associated with increased TDEE (time: p = 0.040). ONE showed small increases in body and fat mass compared with BREAK (interaction: both p ≤ 0.061). No differences were noted in metabolizable energy intake, appetite, or leptin levels. CONCLUSIONS: Spreading short PA bouts throughout the day increases moderate-to-vigorous PA and TDEE to the same extent as a traditional continuous PA bout. Future studies should investigate whether the modest body composition changes observed across interventions are driven by distinct behavioral/physiological compensations influenced by the daily pattern of PA/SB. TRIAL REGISTRATION: ClinicalTrials.gov: NCT02998892.
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BibTeX
@article{andre2026frequent,
title = {{Frequent Versus Single Active Bouts Differentially Affect Movement Behavior and Energy Balance in Adults With Overweight/Obesity}},
author = {Heloisa C. Santo Andre and Elisa Le Roux and Nathan P. De Jong and Patricia R. Smith and Andrew H. Lange and Carlos Mendez and Alexandre Zahariev and Melissa L. Mamele and Ginger Johnson and Zhaoxing Pan and Chantal Simon and Daniel H. Bessesen and Ana J. Pinto and Audrey Bergouignan},
journal = {Obesity},
year = {2026},
month = oct,
doi = {10.1002/oby.70310},
url = {https://hal.science/hal-05798251v1},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Frequent Versus Single Active Bouts Differentially Affect Movement Behavior and Energy Balance in Adults With Overweight/Obesity
AU - Heloisa C. Santo Andre
AU - Elisa Le Roux
AU - Nathan P. De Jong
AU - Patricia R. Smith
AU - Andrew H. Lange
AU - Carlos Mendez
AU - Alexandre Zahariev
AU - Melissa L. Mamele
AU - Ginger Johnson
AU - Zhaoxing Pan
AU - Chantal Simon
AU - Daniel H. Bessesen
AU - Ana J. Pinto
AU - Audrey Bergouignan
PY - 2026
DA - 2026/10/06
JO - Obesity
DO - 10.1002/oby.70310
UR - https://hal.science/hal-05798251v1
AB - OBJECTIVE: This study aimed to investigate the effects of breaking up sedentary behavior (SB) on daily movement behavior and energy balance in adults with overweight/obesity. METHODS: ) were randomized to either BREAK (multiple 5-min brisk walking bouts) or a duration-matched intervention, ONE (45-min brisk walking), performed 5 days/week for 6 weeks. At pre- and post-intervention, daily SB and physical activity (PA; accelerometry), body composition (doubly labeled water [DLW]), total daily energy expenditure (TDEE; DLW), appetite, and fasting leptin were measured. Linear mixed-effects models tested time effects and group-by-time interactions. RESULTS: Only BREAK reduced prolonged SB (interaction: p = 0.043). Both groups shifted SB-PA composition toward greater moderate-to-vigorous PA, with proportional reductions in SB and light PA (time: all p ≤ 0.011). These changes in PA level were associated with increased TDEE (time: p = 0.040). ONE showed small increases in body and fat mass compared with BREAK (interaction: both p ≤ 0.061). No differences were noted in metabolizable energy intake, appetite, or leptin levels. CONCLUSIONS: Spreading short PA bouts throughout the day increases moderate-to-vigorous PA and TDEE to the same extent as a traditional continuous PA bout. Future studies should investigate whether the modest body composition changes observed across interventions are driven by distinct behavioral/physiological compensations influenced by the daily pattern of PA/SB. TRIAL REGISTRATION: ClinicalTrials.gov: NCT02998892.
SN - 1930-7381
SN - 1930-739X
ER -