Renal cortical siderosis: imaging findings and clinical relevance.

Abstract

Renal cortical hemosiderosis is the accumulation of iron in the renal cortex. On MRI, this can be inferred by marked cortical T2 hypointensity and loss of signal on in-phase imaging relative to opposed-phase imaging. Although classically associated with paroxysmal nocturnal hemoglobinuria, renal hemosiderosis can be seen in a variety of pathologic conditions associated with acute or chronic renal injury. We present a case of a 59-year-old female that developed acute kidney injury while hospitalized for management of hydronephrosis and hepatic abscess with imaging features on MR angiography and renal parenchymal biopsy consistent with renal cortical hemosiderosis. Combined with other laboratory results, this finding supports the diagnosis of atypical hemolytic uremic syndrome, a condition with poor prognosis for which timely treatment is essential. Thus, recognition of renal cortical hemosiderosis on imaging may facilitate appropriate clinical workup and timely management.

Glymphatic Imaging in Multiple Sclerosis: Microstructural Constraints on DTI-ALPS and Clinical Relevance of gBOLD-CSF Coupling in Relation to Sleep and Disability
R. Sharifpour, S. Elands, J. Hrabovecky +3
bioRxiv30 Sep 2026PreprintCC BY-NC-NDFull textNeurosciencebioRxiv
Neuroinflammatory Imaging Biomarkers: Relevance to Multiple Sclerosis and its Therapy
Thomas Tourdias, Vincent Dousset
Neurotherapeutics8 Oct 2026Peer-reviewedLicence not statedFull text30 citedNeuroscienceHAL
Functional ultrasound imaging in free-moving marmosets reveals that intra-call prosodic features modulate large-scale cortical dynamics
X. Cheng, Y. Luo, B. Wang +7
bioRxiv2 Nov 2026PreprintAll rights reservedFull textNeurosciencebioRxiv
Abdominal Magnetic Resonance Imaging (MRI) Findings Prompting the Diagnosis of Paroxysmal Nocturnal Hemoglobinuria: A Case Report.
Camila Velez, Ana Maria Ramirez, Sebastian Peláez +1
Cureus21 Sep 2026Peer-reviewedCC BYFull textImmunologyEurope PMC
Temporally constraining source imaging estimates in an underdetermined neural system with eigenmodes of cortical geometry
Pok Him Siu, Philippa J. Karoly, Artemio Soto-Breceda +2
arXiv2 Sep 2026PreprintCC BY 4.0Full textNeuroscience Biological & medical physicsarXiv

Cite

BibTeX RIS

BibTeX

@article{shah2026renal,
  title = {{Renal cortical siderosis: imaging findings and clinical relevance.}},
  author = {Amar S Shah and Kyle J Chen and Mark Sugi},
  journal = {BJR case reports},
  year = {2026},
  month = sep,
  doi = {10.1093/bjrcr/uaag043},
  url = {https://europepmc.org/article/MED/42927408},
  note = {CC BY},
}

RIS

TY  - JOUR
TI  - Renal cortical siderosis: imaging findings and clinical relevance.
AU  - Amar S Shah
AU  - Kyle J Chen
AU  - Mark Sugi
PY  - 2026
DA  - 2026/09/01
JO  - BJR case reports
DO  - 10.1093/bjrcr/uaag043
UR  - https://europepmc.org/article/MED/42927408
AB  - Renal cortical hemosiderosis is the accumulation of iron in the renal cortex. On MRI, this can be inferred by marked cortical T2 hypointensity and loss of signal on in-phase imaging relative to opposed-phase imaging. Although classically associated with paroxysmal nocturnal hemoglobinuria, renal hemosiderosis can be seen in a variety of pathologic conditions associated with acute or chronic renal injury. We present a case of a 59-year-old female that developed acute kidney injury while hospitalized for management of hydronephrosis and hepatic abscess with imaging features on MR angiography and renal parenchymal biopsy consistent with renal cortical hemosiderosis. Combined with other laboratory results, this finding supports the diagnosis of atypical hemolytic uremic syndrome, a condition with poor prognosis for which timely treatment is essential. Thus, recognition of renal cortical hemosiderosis on imaging may facilitate appropriate clinical workup and timely management.
SN  - 2055-7159
ER  -

Abstract

Related

Cite