Identification of Patients with Colon Ischemia in the Swedish ESPRESSO Cohort: A Validation Study.
9 affiliations
- 1Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden.
- 2Department of Surgery, Södersjukhuset, Stockholm, Sweden.
- 3Division of Clinical Epidemiology, Department of Medicine Solna, Karolinska Institute, Stockholm, Sweden.
- 4Centre for Digestive Health, Department of Gastroenterology, Dermatovenereology and Rheumatology, Karolinska University Hospital, Stockholm, Sweden.
- 5Department of Medicine Solna, Karolinska Institute, Stockholm, Sweden.
- 6Department of Women's and Children's Health, Karolinska Institute, Stockholm, Sweden.
- 7Section of Pediatric Surgery, Karolinska University Hospital, Stockholm, Sweden.
- 8Department of Pediatrics, Örebro University Hospital, Örebro, Sweden.
- 9Department of Clinical Science and Education, Södersjukhuset, Karolinska Institute, Stockholm, Sweden.
Abstract
Background
Colon ischemia is the most common form of intestinal ischemia, yet case identification in epidemiological research remains challenging due to heterogeneous diagnostic criteria and absence of a specific International Classification of Diseases (ICD) code. The use of SNOMED (Systematized Nomenclature of Medicine) for gastrointestinal biopsies and surgical specimens enables a unique possibility to identify colon ischemia cases.Methods
In this validation study, 231 individuals with SNOMED code M54 (necrosis) and colorectal topography codes (T67-T68) were randomly selected from five Swedish regions. Medical charts were retrieved for 204 cases, where 143 contained sufficient information for evaluation. Cases were classified by clinical overall assessment and assigned an etiological group. Positive predictive values (PPVs) were calculated for overall colon ischemia based on histopathology alone and for etiological subsets where histopathology was combined with ICD codes.Results
Of 143 patients with sufficient clinical information for validation, histopathological ischemic injury of the colon was confirmed in 141, corresponding to a PPV of 99% (95% CI, 95-99%). Combining SNOMED codes with selected ICD codes yielded a PPV of 84% (95% CI, 73-92%) for clinically confirmed idiopathic colon ischemia, increasing to 92% (95% CI, 79-98%) when more restrictive ICD-based criteria were applied.Conclusion
SNOMED-based histopathological case identification demonstrated a very high PPV for ischemic injury of the colon but could not distinguish idiopathic disease from ischemia secondary to identifiable clinical conditions. Combining SNOMED and ICD codes provides a feasible and reproducible strategy for identifying underlying causes of colon ischemia in Swedish nationwide health registers.
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BibTeX
@article{klinglof2026identification,
title = {{Identification of Patients with Colon Ischemia in the Swedish ESPRESSO Cohort: A Validation Study.}},
author = {Helene Klinglöf and Jonas Söderling and Charlotte R H Hedin and Thomas Frisell and Anna Löf Granström and Jonas F Ludvigsson and Åsa H Everhov},
journal = {Clinical epidemiology},
year = {2026},
month = oct,
doi = {10.2147/clep.s616678},
url = {https://europepmc.org/article/MED/42928875},
note = {CC BY-NC},
}
RIS
TY - JOUR
TI - Identification of Patients with Colon Ischemia in the Swedish ESPRESSO Cohort: A Validation Study.
AU - Helene Klinglöf
AU - Jonas Söderling
AU - Charlotte R H Hedin
AU - Thomas Frisell
AU - Anna Löf Granström
AU - Jonas F Ludvigsson
AU - Åsa H Everhov
PY - 2026
DA - 2026/10/21
JO - Clinical epidemiology
DO - 10.2147/clep.s616678
UR - https://europepmc.org/article/MED/42928875
AB - Background Colon ischemia is the most common form of intestinal ischemia, yet case identification in epidemiological research remains challenging due to heterogeneous diagnostic criteria and absence of a specific International Classification of Diseases (ICD) code. The use of SNOMED (Systematized Nomenclature of Medicine) for gastrointestinal biopsies and surgical specimens enables a unique possibility to identify colon ischemia cases.Methods In this validation study, 231 individuals with SNOMED code M54 (necrosis) and colorectal topography codes (T67-T68) were randomly selected from five Swedish regions. Medical charts were retrieved for 204 cases, where 143 contained sufficient information for evaluation. Cases were classified by clinical overall assessment and assigned an etiological group. Positive predictive values (PPVs) were calculated for overall colon ischemia based on histopathology alone and for etiological subsets where histopathology was combined with ICD codes.Results Of 143 patients with sufficient clinical information for validation, histopathological ischemic injury of the colon was confirmed in 141, corresponding to a PPV of 99% (95% CI, 95-99%). Combining SNOMED codes with selected ICD codes yielded a PPV of 84% (95% CI, 73-92%) for clinically confirmed idiopathic colon ischemia, increasing to 92% (95% CI, 79-98%) when more restrictive ICD-based criteria were applied.Conclusion SNOMED-based histopathological case identification demonstrated a very high PPV for ischemic injury of the colon but could not distinguish idiopathic disease from ischemia secondary to identifiable clinical conditions. Combining SNOMED and ICD codes provides a feasible and reproducible strategy for identifying underlying causes of colon ischemia in Swedish nationwide health registers.
SN - 1179-1349
ER -