Application of radial artery signal characteristics in long-term head-down bed rest experimental cardiovascular status assessment
4 affiliations
- 1School of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China
- 2School of Artificial Intelligence of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China
- 3National Key Laboratory of Space Medicine, China Astronaut Research and Training Center, Beijing, China
- 4School of Integrative Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China
Abstract
Objective: This study aims to observe pulse graph parameters and their dynamic changes in subjects of the head-down bed rest (HDBR) under different exercise interventions and to evaluate their application value in simulating cardiovascular function changes in weightlessness.
Methods: A total of 36 male volunteers (32.0 ± 2.6 years) participated in a 138-day experiment (15 days at baseline, 90 days at -6° HDBR, and 33 days at recovery). Radial pulse graphs were collected at 11 time points: the baseline, D7, D15, D30, D45, D60, D75, D90 during bedrest, and R + 7, R + 15, and R + 30 during the recovery. Cardiac structural and functional parameters, along with arterial elasticity and blood flow parameters, were recorded simultaneously. The feasibility of TCM pulse diagnosis for assessing cardiovascular status in HDBR subjects was explored through correlation analyses between pulse parameters and ultrasound indicators.
Results: (1) During bedrest, pulse parameters h1, h3, h4, t5, t, As, Ad, and h4/h1 showed an upward trend and decreased during the recovery stage. PWVρ, crPWV, LICAvmax, and LFAvmax increased initially and then decreased, whereas IMT showed a sustained increase. (2) The aerobic exercise plus resistance training group showed faster adaption to HDBR and better cardiovascular functional recovery after long-term HDBR. (3) Canonical correlation and bivariate correlation analyses showed varying degrees of correlation between the two types of indicators, with some correlation coefficients >0.7 (P < 0.05). (4) Repeated measurements showed statistically significant differences in pulse graph parameters, with cfPWV, crPWV, and PWVρ showing an increasing trend followed by a decrease.
Conclusion: Cardiovascular changes induced by HDBR can be reflected in pulse graph parameters; radial pulse wave parameters may serve as valuable references for the dynamic monitoring and assessment of cardiovascular function under simulated weightlessness.
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BibTeX
@article{ha2026application,
title = {{Application of radial artery signal characteristics in long-term head-down bed rest experimental cardiovascular status assessment}},
author = {Kaiting Ha and Xiaojuan Hu and Dong Liu and Guohao Zhang and Shuyi Zhang and Shiju Zhao and Liping Tu and Tao Jiang and Xuxiang Ma and Quanchun Fan and Junlian Liu and Chengpu Zhang and Hongzhi Shi and Jiatuo Xu and Ji Cui},
journal = {Frontiers in Physiology},
year = {2026},
month = oct,
doi = {10.3389/fphys.2026.1961052},
url = {https://doi.org/10.3389/fphys.2026.1961052},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Application of radial artery signal characteristics in long-term head-down bed rest experimental cardiovascular status assessment
AU - Kaiting Ha
AU - Xiaojuan Hu
AU - Dong Liu
AU - Guohao Zhang
AU - Shuyi Zhang
AU - Shiju Zhao
AU - Liping Tu
AU - Tao Jiang
AU - Xuxiang Ma
AU - Quanchun Fan
AU - Junlian Liu
AU - Chengpu Zhang
AU - Hongzhi Shi
AU - Jiatuo Xu
AU - Ji Cui
PY - 2026
DA - 2026/10/21
JO - Frontiers in Physiology
DO - 10.3389/fphys.2026.1961052
UR - https://doi.org/10.3389/fphys.2026.1961052
AB - Objective: This study aims to observe pulse graph parameters and their dynamic changes in subjects of the head-down bed rest (HDBR) under different exercise interventions and to evaluate their application value in simulating cardiovascular function changes in weightlessness. Methods: A total of 36 male volunteers (32.0 ± 2.6 years) participated in a 138-day experiment (15 days at baseline, 90 days at -6° HDBR, and 33 days at recovery). Radial pulse graphs were collected at 11 time points: the baseline, D7, D15, D30, D45, D60, D75, D90 during bedrest, and R + 7, R + 15, and R + 30 during the recovery. Cardiac structural and functional parameters, along with arterial elasticity and blood flow parameters, were recorded simultaneously. The feasibility of TCM pulse diagnosis for assessing cardiovascular status in HDBR subjects was explored through correlation analyses between pulse parameters and ultrasound indicators. Results: (1) During bedrest, pulse parameters h1, h3, h4, t5, t, As, Ad, and h4/h1 showed an upward trend and decreased during the recovery stage. PWVρ, crPWV, LICAvmax, and LFAvmax increased initially and then decreased, whereas IMT showed a sustained increase. (2) The aerobic exercise plus resistance training group showed faster adaption to HDBR and better cardiovascular functional recovery after long-term HDBR. (3) Canonical correlation and bivariate correlation analyses showed varying degrees of correlation between the two types of indicators, with some correlation coefficients >0.7 (P < 0.05). (4) Repeated measurements showed statistically significant differences in pulse graph parameters, with cfPWV, crPWV, and PWVρ showing an increasing trend followed by a decrease. Conclusion: Cardiovascular changes induced by HDBR can be reflected in pulse graph parameters; radial pulse wave parameters may serve as valuable references for the dynamic monitoring and assessment of cardiovascular function under simulated weightlessness.
SN - 1664-042X
ER -