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Peer-reviewedCC BY-NC-ND 4.0Npj Autoimmunity

High-dimensionality approaches to the understanding and therapeutic manipulation of autoimmunity

  • Vasuki-Ranjani Chellamuthu1
  • Yunqian Zhao1
  • Salvatore Albani1,2
  1. 1Translational Immunology Institute, SingHealth/Duke-NUS Academic Medical Centre, Singapore, Singapore
  2. 2Duke-NUS Medical School, Singapore, Singapore
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Abstract

Autoimmune disease may arise from disruptions in immune architecture rather than isolated molecular defects. High-dimensional immunology now reveals dynamic cellular states, regulatory circuits, and tissue-specific immune niches, but translation into therapy remains limited. We propose an Architecture-Anomaly-Target-Lead framework that contextualises therapeutic targets within immune organisation and complements Reset-Rebuild strategies. Together, these concepts provide a framework for developing and evaluating more sustained, tolerance-focused treatment approaches for autoimmune disease.

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Cite

BibTeXRIS
BibTeX
@article{chellamuthu2026highdimensionality,
  title = {{High-dimensionality approaches to the understanding and therapeutic manipulation of autoimmunity}},
  author = {Vasuki-Ranjani Chellamuthu and Yunqian Zhao and Salvatore Albani},
  journal = {Npj Autoimmunity},
  year = {2026},
  month = oct,
  doi = {10.1038/s44483-026-00007-0},
  url = {https://doi.org/10.1038/s44483-026-00007-0},
  note = {CC BY-NC-ND 4.0},
}
RIS
TY  - JOUR
TI  - High-dimensionality approaches to the understanding and therapeutic manipulation of autoimmunity
AU  - Vasuki-Ranjani Chellamuthu
AU  - Yunqian Zhao
AU  - Salvatore Albani
PY  - 2026
DA  - 2026/10/31
JO  - Npj Autoimmunity
DO  - 10.1038/s44483-026-00007-0
UR  - https://doi.org/10.1038/s44483-026-00007-0
AB  - Autoimmune disease may arise from disruptions in immune architecture rather than isolated molecular defects. High-dimensional immunology now reveals dynamic cellular states, regulatory circuits, and tissue-specific immune niches, but translation into therapy remains limited. We propose an Architecture-Anomaly-Target-Lead framework that contextualises therapeutic targets within immune organisation and complements Reset-Rebuild strategies. Together, these concepts provide a framework for developing and evaluating more sustained, tolerance-focused treatment approaches for autoimmune disease.
SN  - 3091-2792
ER  -