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Peer-reviewedCC BYInternational Journal of Biological Sciences

A context-dependent METTL1-m7G-SLC7A11 axis links metabolic stress to epithelial fate in ulcerative colitis

  • Lichao Yang1,2
  • Qi Sun2
  • Zhixian Jiang2
  • Baojia Yao2
  • Caimei Yang2
  • Ganglei Liu2
  • Lianwen Yuan2
  1. 1Center for Clinical Sciences, Japan Institute for Health Security, Tokyo, Japan
  2. 2Department of General Surgery, The Second Xiangya Hospital of Central South University, 410011 Changsha, China
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Abstract

, inhibition of the METTL1/m7G/SLC7A11 axis exacerbates chronic DSS-induced colitis but alleviates acute DSS-induced colitis, revealing a switch from adaptive to maladaptive signaling with escalating metabolic stress. Collectively, these findings establish the METTL1-m7G-SLC7A11 axis as a metabolic rheostat that integrates inflammatory cues and nutrient availability to determine epithelial cell fate in UC, highlighting the importance of stage- and context-specific therapeutic strategies.

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Cite

BibTeXRIS
BibTeX
@article{yang2026contextdependent,
  title = {{A context-dependent METTL1-m7G-SLC7A11 axis links metabolic stress to epithelial fate in ulcerative colitis}},
  author = {Lichao Yang and Qi Sun and Zhixian Jiang and Baojia Yao and Caimei Yang and Ganglei Liu and Lianwen Yuan},
  journal = {International Journal of Biological Sciences},
  year = {2026},
  month = may,
  doi = {10.7150/ijbs.133562},
  url = {https://doi.org/10.7150/ijbs.133562},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - A context-dependent METTL1-m7G-SLC7A11 axis links metabolic stress to epithelial fate in ulcerative colitis
AU  - Lichao Yang
AU  - Qi Sun
AU  - Zhixian Jiang
AU  - Baojia Yao
AU  - Caimei Yang
AU  - Ganglei Liu
AU  - Lianwen Yuan
PY  - 2026
DA  - 2026/05/11
JO  - International Journal of Biological Sciences
DO  - 10.7150/ijbs.133562
UR  - https://doi.org/10.7150/ijbs.133562
AB  - , inhibition of the METTL1/m7G/SLC7A11 axis exacerbates chronic DSS-induced colitis but alleviates acute DSS-induced colitis, revealing a switch from adaptive to maladaptive signaling with escalating metabolic stress. Collectively, these findings establish the METTL1-m7G-SLC7A11 axis as a metabolic rheostat that integrates inflammatory cues and nutrient availability to determine epithelial cell fate in UC, highlighting the importance of stage- and context-specific therapeutic strategies.
SN  - 1449-2288
ER  -