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PreprintCC BY-NC-NDbioRxiv

Responses of Muscle Volume, Strength, and Motor Unit Properties to Bed Rest and Retraining in Young Males and Females

  • F. Sarto1
  • M. Kalc
  • O. Caputo
  • K. Pus
  • R. Magris
  • G. Martino
  • C. M. Brusco
  • M. V. Franchi
  • G. De Vito
  • F. Ferranti
  • B. Simunic
  • R. Pisot
1 more authors
  • M. V. Narici
  1. 1Department of Biomedical Sciences, University of Padova, Padova, Italy
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Abstract

Sex differences in motor unit (MU) properties to simulated microgravity are unknown. Young males and females completed a 21-day head-down bed rest followed by a 21-day retraining. Bed rest reduced knee extensor strength and volume without sex differences. MU firing rate decreased in both groups, more in females, alongside increased serum C-terminal agrin fragment. After retraining, these measures returned to baseline, whereas strength only partially recovered, remaining below baseline.

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Cite

BibTeXRIS
BibTeX
@misc{sarto2026responses,
  title = {{Responses of Muscle Volume, Strength, and Motor Unit Properties to Bed Rest and Retraining in Young Males and Females}},
  author = {F. Sarto and M. Kalc and O. Caputo and K. Pus and R. Magris and G. Martino and C. M. Brusco and M. V. Franchi and G. De Vito and F. Ferranti and B. Simunic and R. Pisot and M. V. Narici},
  howpublished = {bioRxiv},
  year = {2026},
  month = nov,
  doi = {10.64898/2026.11.04.764387},
  url = {https://www.biorxiv.org/content/10.64898/2026.11.04.764387v1},
  note = {CC BY-NC-ND},
}
RIS
TY  - UNPB
TI  - Responses of Muscle Volume, Strength, and Motor Unit Properties to Bed Rest and Retraining in Young Males and Females
AU  - F. Sarto
AU  - M. Kalc
AU  - O. Caputo
AU  - K. Pus
AU  - R. Magris
AU  - G. Martino
AU  - C. M. Brusco
AU  - M. V. Franchi
AU  - G. De Vito
AU  - F. Ferranti
AU  - B. Simunic
AU  - R. Pisot
AU  - M. V. Narici
PY  - 2026
DA  - 2026/11/04
PB  - bioRxiv
DO  - 10.64898/2026.11.04.764387
UR  - https://www.biorxiv.org/content/10.64898/2026.11.04.764387v1
AB  - Sex differences in motor unit (MU) properties to simulated microgravity are unknown. Young males and females completed a 21-day head-down bed rest followed by a 21-day retraining. Bed rest reduced knee extensor strength and volume without sex differences. MU firing rate decreased in both groups, more in females, alongside increased serum C-terminal agrin fragment. After retraining, these measures returned to baseline, whereas strength only partially recovered, remaining below baseline.
ER  -