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Peer-reviewedCC BYNano letters

The Need to Distinguish Colloidal and Thermal Stability for Proteins.

  • Cécilia Siri1
  • Ekaterina Poliukhina1
  • Quy Khac Ong1
  • Francesco Stellacci1,2
  1. 1Institute of Materials, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015Lausanne, Switzerland.
  2. 2Institute of Bioengineering, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015Lausanne, Switzerland.
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Abstract

Protein stability is crucial in the development of drug formulations and in understanding many aspects of protein behavior. It is known that both thermal and colloidal protein stability are modulated by the presence of small molecules. Because thermal stability is easier to assess than colloidal stability, it is often used as a proxy for evaluating the latter. In this Mini-Review, we argue that these two aspects of stability have to be considered separately, although they should be related in some complex way.

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Cite

BibTeXRIS
BibTeX
@article{siri2026need,
  title = {{The Need to Distinguish Colloidal and Thermal Stability for Proteins.}},
  author = {Cécilia Siri and Ekaterina Poliukhina and Quy Khac Ong and Francesco Stellacci},
  journal = {Nano letters},
  year = {2026},
  month = sep,
  doi = {10.1021/acs.nanolett.6c03345},
  url = {https://europepmc.org/article/MED/42915363},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - The Need to Distinguish Colloidal and Thermal Stability for Proteins.
AU  - Cécilia Siri
AU  - Ekaterina Poliukhina
AU  - Quy Khac Ong
AU  - Francesco Stellacci
PY  - 2026
DA  - 2026/09/01
JO  - Nano letters
DO  - 10.1021/acs.nanolett.6c03345
UR  - https://europepmc.org/article/MED/42915363
AB  - Protein stability is crucial in the development of drug formulations and in understanding many aspects of protein behavior. It is known that both thermal and colloidal protein stability are modulated by the presence of small molecules. Because thermal stability is easier to assess than colloidal stability, it is often used as a proxy for evaluating the latter. In this Mini-Review, we argue that these two aspects of stability have to be considered separately, although they should be related in some complex way.
SN  - 1530-6984
SN  - 1530-6992
ER  -