Skip to content
DraconiticResearch
Search Sources API
201,818 studies31 sourcesUpdated 23 min ago
Peer-reviewedCC BYClinical Epidemiology and Global Health

Multisystem inflammatory syndrome in children (MIS-C) burden in India: A multicentre implementation research study

  • Anoop Velayudhan1
  • P. Majumdar2
  • G. Kumar3
  • A. Turuk4
  • Anshuman Thakur3
  • Sharma SK5
  • P. Shukla4
  • Chander BT5
  • V. Rajesh5
  • M. Rajarao6
  • P. Bhardwaj7
  • A. Kumar8
18 more authors
  • I. Saini8
  • A. Singh9
  • S. Shivnitwar10
  • S. Tripathy10
  • S. Kanitkar10
  • M. Barthwal10
  • A.L. Kakrani10
  • S. Mane11
  • M. Shameem11
  • N. Fatima11
  • A. Bhalla12
  • J. Murlidharan12
  • S. Paul12
  • R. Choudhury13
  • M. Rao13
  • S. Pala14
  • H. Barman14
  • A. Mukherjee4
14 affiliations
  1. 1SD Gupta School of Public Health, IIHMR University, Jaipur, Rajasthan, India; Corresponding author. SD Gupta School of Public Health, IIHMR University, 1 Prabhu Dayal Marg, Sanganer, Jaipur, 302029, Rajasthan, India.
  2. 2SD Gupta School of Public Health, IIHMR University, Jaipur, Rajasthan, India
  3. 3Indian Council of Medical Research Headquarters, New Delhi, India
  4. 4National Institute of Child Health Research, New Delhi, India
  5. 5Kakatiya Medical College, Warangal, Telangana, India
  6. 6Osmania Medical College, Hyderabad, Telangana, India
  7. 7Indian Council of Medical Research-National Institute of Health Research, Jodhpur, Rajasthan, India
  8. 8Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, New Delhi, Delhi, 110029, India
  9. 9Dr D Y Patil Medical College & Research Centre, Pimpri, Pune, Maharashtra, 411018, India; Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, New Delhi, Delhi, 110029, India
  10. 10Dr D Y Patil Medical College & Research Centre, Pimpri, Pune, Maharashtra, 411018, India
  11. 11Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh, Uttar Pradesh, India
  12. 12Postgraduate Institute of Medical Education and Research, Chandigarh, India
  13. 13St. John's Medical College, Bengaluru, Karnataka, India
  14. 14North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences, Shillong, Meghalaya, India
Read full textDOICite

Abstract

Background: Multisystem inflammatory syndrome in children (MIS-C) is a severe post-infectious complication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. The condition has limited evidence and requires further exploration in countries such as India. Objectives: To estimate the proportion of suspected cases classified as MIS-C and describe clinical features, severity, treatment and outcomes within the Indian Council of Medical Research (ICMR) National Clinical Registry for COVID-19. Methods: Twelve tertiary hospitals in 11 states and union territories contributed to a registry extension, with retrospective review (April 2020-December 2022) and prospective surveillance (January 2023-June 2024). Cases were classified using the World Health Organization (WHO) definition, and analyses used the data available for each variable. Results: Of 217 suspected cases, 41 (18.9%; 95% confidence interval 14.2-24.6%) were classified as MIS-C and 176 as not confirmed. Among confirmed cases, 43.9% were aged 0-4 years, 53.7% were aged 5-14 years, and 70.7% were male. Fever was universal; shock and respiratory features were more frequent than in not confirmed cases. Of 35 confirmed children with data, 21 (60.0%) required intensive care, and one of 41 died. Corticosteroids and intravenous immunoglobulin were administered to 65.9% and 61.0% of patients, respectively. Conclusion: Extending an existing registry to paediatric departments provided a multicentric estimate among hospitalised suspected cases and a practical model for paediatric surveillance in resource-limited settings.

Related

  1. Clinical Phenotype and Outcomes of Multisystem Inflammatory Syndrome in Children According to SARS‐CoV‐2 Laboratory Status During 2020–2021: A Retrospective Observational Study
    Shahnaz Armin, Seyede Mahsan Hoseini‐Alfatemi, Roxana Mansour Ghanaiee +6
    Health Science ReportsPeer-reviewedCC BY-NC-ND 4.0Full textObstetrics, gynaecology & paediatricsPMC
  2. Persistent hypogammaglobulinaemia after rituximab in children with difficult-to-treat nephrotic syndrome: a multicentre cross-sectional observational study
    Suchismita Saha, Deepshikha Baranwal, Subhankar Sarkar +4
    BMJ Paediatrics OpenPeer-reviewedCC BY-NC 4.0Full textGeneral medicinePMC
  3. Efficacy and safety of risk-stratified chemotherapy with azacitidine for children with myeloid leukaemia with Down syndrome: protocol for a multicentre phase II trial (JCCG AML-D24)
    Kentaro Nakashima, Daisuke Hasegawa, Jun Matsubayashi +21
    BMJ OpenPeer-reviewedCC BY-NC 4.0Full textGeneral medicineCrossref
  4. Transient Post-infectious Multisystem Inflammatory Overlap Presentation in a Pediatric Patient With Neurological, Hepatic, Gastrointestinal, and Autoimmune Manifestations: A Rare Case From Azerbaijan
    Divya Ravikumar, Aliakbar Hasanov, Fakhriya Mammadova +2
    CureusPeer-reviewedCC BYFull textGeneral medicineEurope PMC
  5. Implementation of a complex intervention for hip fracture care: a protocol for an embedded mixed-methods process evaluation of a multicentre cluster randomised trial in India, Nepal, the Philippines, Thailand and Vietnam.
    Elizabeth Armstrong, Rebecca Ivers, Thuy Anh Bui +20
    BMJ openPeer-reviewedCC BYFull textGeneral medicineEurope PMCCrossref

Cite

BibTeXRIS
BibTeX
@article{velayudhan2026multisystem,
  title = {{Multisystem inflammatory syndrome in children (MIS-C) burden in India: A multicentre implementation research study}},
  author = {Anoop Velayudhan and P. Majumdar and G. Kumar and A. Turuk and Anshuman Thakur and Sharma SK and P. Shukla and Chander BT and V. Rajesh and M. Rajarao and P. Bhardwaj and A. Kumar and I. Saini and A. Singh and S. Shivnitwar and S. Tripathy and S. Kanitkar and M. Barthwal and A.L. Kakrani and S. Mane and M. Shameem and N. Fatima and A. Bhalla and J. Murlidharan and S. Paul and R. Choudhury and M. Rao and S. Pala and H. Barman and A. Mukherjee},
  journal = {Clinical Epidemiology and Global Health},
  year = {2026},
  month = oct,
  doi = {10.1016/j.cegh.2026.102512},
  url = {https://doi.org/10.1016/j.cegh.2026.102512},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Multisystem inflammatory syndrome in children (MIS-C) burden in India: A multicentre implementation research study
AU  - Anoop Velayudhan
AU  - P. Majumdar
AU  - G. Kumar
AU  - A. Turuk
AU  - Anshuman Thakur
AU  - Sharma SK
AU  - P. Shukla
AU  - Chander BT
AU  - V. Rajesh
AU  - M. Rajarao
AU  - P. Bhardwaj
AU  - A. Kumar
AU  - I. Saini
AU  - A. Singh
AU  - S. Shivnitwar
AU  - S. Tripathy
AU  - S. Kanitkar
AU  - M. Barthwal
AU  - A.L. Kakrani
AU  - S. Mane
AU  - M. Shameem
AU  - N. Fatima
AU  - A. Bhalla
AU  - J. Murlidharan
AU  - S. Paul
AU  - R. Choudhury
AU  - M. Rao
AU  - S. Pala
AU  - H. Barman
AU  - A. Mukherjee
PY  - 2026
DA  - 2026/10/30
JO  - Clinical Epidemiology and Global Health
DO  - 10.1016/j.cegh.2026.102512
UR  - https://doi.org/10.1016/j.cegh.2026.102512
AB  - Background: Multisystem inflammatory syndrome in children (MIS-C) is a severe post-infectious complication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. The condition has limited evidence and requires further exploration in countries such as India. Objectives: To estimate the proportion of suspected cases classified as MIS-C and describe clinical features, severity, treatment and outcomes within the Indian Council of Medical Research (ICMR) National Clinical Registry for COVID-19. Methods: Twelve tertiary hospitals in 11 states and union territories contributed to a registry extension, with retrospective review (April 2020-December 2022) and prospective surveillance (January 2023-June 2024). Cases were classified using the World Health Organization (WHO) definition, and analyses used the data available for each variable. Results: Of 217 suspected cases, 41 (18.9%; 95% confidence interval 14.2-24.6%) were classified as MIS-C and 176 as not confirmed. Among confirmed cases, 43.9% were aged 0-4 years, 53.7% were aged 5-14 years, and 70.7% were male. Fever was universal; shock and respiratory features were more frequent than in not confirmed cases. Of 35 confirmed children with data, 21 (60.0%) required intensive care, and one of 41 died. Corticosteroids and intravenous immunoglobulin were administered to 65.9% and 61.0% of patients, respectively. Conclusion: Extending an existing registry to paediatric departments provided a multicentric estimate among hospitalised suspected cases and a practical model for paediatric surveillance in resource-limited settings.
SN  - 2213-3984
SN  - 2452-0918
ER  -