Multi‐segment intussusception in infant with suspected celiac crisis: A case report
- 1Department of Pediatrics University of California, San Francisco Oakland California USA
- 2Department of Pathology University of California, San Francisco San Francisco California USA
Abstract
Celiac crisis (CC) is a rare, life‐threatening manifestation of often undiagnosed or inadequately treated celiac disease (CeD). In infants with nonclassical presentations of CeD, timely diagnosis can be challenging but critical to reducing end‐organ damage and serious complications, such as CC. We report a case of a 14‐month‐old infant presenting with 1 month of inappetence, malnutrition, and abdominal pain in the absence of diarrhea. The infant was found to have extraintestinal manifestations suggestive of CC, such as electrolyte derangement, hypoalbuminemia, and neurologic dysfunction. However, the infant also presented with unusual multi‐segment small bowel‐small bowel intussusception prior to the diagnosis of CeD. Intussusception may reflect severe small bowel enteropathy in CeD. Hypoalbuminemia and intestinal edema seen in CC may further precipitate small bowel‐small bowel intussusception. Future studies should clarify distinct phenotypes of infantile‐onset CeD associated with more severe CC.
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BibTeX
@article{thakur2026multisegment,
title = {{Multi‐segment intussusception in infant with suspected celiac crisis: A case report}},
author = {Shambhawi Thakur and Angela Tran and Vivien Nguyen and Soo‐Jin Cho and Telly Cheung},
journal = {JPGN Reports},
year = {2026},
month = nov,
doi = {10.1002/jpr3.70269},
url = {https://doi.org/10.1002/jpr3.70269},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Multi‐segment intussusception in infant with suspected celiac crisis: A case report
AU - Shambhawi Thakur
AU - Angela Tran
AU - Vivien Nguyen
AU - Soo‐Jin Cho
AU - Telly Cheung
PY - 2026
DA - 2026/11/05
JO - JPGN Reports
DO - 10.1002/jpr3.70269
UR - https://doi.org/10.1002/jpr3.70269
AB - Celiac crisis (CC) is a rare, life‐threatening manifestation of often undiagnosed or inadequately treated celiac disease (CeD). In infants with nonclassical presentations of CeD, timely diagnosis can be challenging but critical to reducing end‐organ damage and serious complications, such as CC. We report a case of a 14‐month‐old infant presenting with 1 month of inappetence, malnutrition, and abdominal pain in the absence of diarrhea. The infant was found to have extraintestinal manifestations suggestive of CC, such as electrolyte derangement, hypoalbuminemia, and neurologic dysfunction. However, the infant also presented with unusual multi‐segment small bowel‐small bowel intussusception prior to the diagnosis of CeD. Intussusception may reflect severe small bowel enteropathy in CeD. Hypoalbuminemia and intestinal edema seen in CC may further precipitate small bowel‐small bowel intussusception. Future studies should clarify distinct phenotypes of infantile‐onset CeD associated with more severe CC.
SN - 2691-171X
ER -