Multidimensional T1-T2 Relaxation Imaging In Vivo on a Portable 0.064~T MRI Scanner
- 1Section on Quantitative Imaging and Tissue Sciences, National Institute of Child Health and Human Development (NICHD), National Institutes of Health, Bethesda,
Abstract
Purpose: To demonstrate the feasibility of whole-brain multidimensional T1-T2 relaxation imaging on a portable 0.064 T MRI scanner. Methods: A two-dimensional inversion-recovery, fast spin-echo acquisition was used to jointly encode T1 and T2 relaxation. Joint relaxation distributions were reconstructed voxel-wise using marginal-distribution constrained optimization (MADCO). The approach was evaluated in a quantitative relaxation MRI phantom and subsequently applied in vivo in a healthy volunteer. Joint distributions, marginal distributions, distribution-derived measures, and statistical dependencies between the two relaxation dimensions were examined. Results: Phantom joint relaxation estimates showed good overall agreement with mono-exponential relaxation measurements and previously reported values at 0.064 T. The in vivo acquisition provided whole-brain coverage over a broad range of relaxation weightings and tissue contrasts. Reconstructed joint T1-T2 distributions showed spatially organized features across the relaxation space, including broad and overlapping relaxation components that were not fully represented by single-value relaxation maps or by either 1D marginal distribution alone. Selected regions of the joint relaxation space produced component maps with distinct spatial patterns. Statistical analysis further showed a dependence between the two relaxation dimensions, supporting the presence of added information in the joint distribution that is lost when treating T1 and T2 separately. Conclusion: Whole-brain multidimensional T1-T2 relaxation imaging is clinically feasible on a portable 0.064 T MRI scanner. Joint relaxation distributions provide information beyond single-value relaxation mapping and may support further developments of quantitative multidimensional imaging at ultra-low field.
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BibTeX
@misc{wilczynski2026multidimensional,
title = {{Multidimensional T1-T2 Relaxation Imaging In Vivo on a Portable 0.064~T MRI Scanner}},
author = {E. Wilczynski and K. Najmudeen Magdoom and A. V. Avram and N. H. Williamson and D. Benjamini and S. G. Horovitz and P. J. Basser},
howpublished = {bioRxiv},
year = {2026},
month = sep,
doi = {10.64898/2026.09.04.749459},
url = {https://www.biorxiv.org/content/10.64898/2026.09.04.749459v1},
note = {CC0},
}
RIS
TY - UNPB
TI - Multidimensional T1-T2 Relaxation Imaging In Vivo on a Portable 0.064~T MRI Scanner
AU - E. Wilczynski
AU - K. Najmudeen Magdoom
AU - A. V. Avram
AU - N. H. Williamson
AU - D. Benjamini
AU - S. G. Horovitz
AU - P. J. Basser
PY - 2026
DA - 2026/09/04
PB - bioRxiv
DO - 10.64898/2026.09.04.749459
UR - https://www.biorxiv.org/content/10.64898/2026.09.04.749459v1
AB - Purpose: To demonstrate the feasibility of whole-brain multidimensional T1-T2 relaxation imaging on a portable 0.064 T MRI scanner. Methods: A two-dimensional inversion-recovery, fast spin-echo acquisition was used to jointly encode T1 and T2 relaxation. Joint relaxation distributions were reconstructed voxel-wise using marginal-distribution constrained optimization (MADCO). The approach was evaluated in a quantitative relaxation MRI phantom and subsequently applied in vivo in a healthy volunteer. Joint distributions, marginal distributions, distribution-derived measures, and statistical dependencies between the two relaxation dimensions were examined. Results: Phantom joint relaxation estimates showed good overall agreement with mono-exponential relaxation measurements and previously reported values at 0.064 T. The in vivo acquisition provided whole-brain coverage over a broad range of relaxation weightings and tissue contrasts. Reconstructed joint T1-T2 distributions showed spatially organized features across the relaxation space, including broad and overlapping relaxation components that were not fully represented by single-value relaxation maps or by either 1D marginal distribution alone. Selected regions of the joint relaxation space produced component maps with distinct spatial patterns. Statistical analysis further showed a dependence between the two relaxation dimensions, supporting the presence of added information in the joint distribution that is lost when treating T1 and T2 separately. Conclusion: Whole-brain multidimensional T1-T2 relaxation imaging is clinically feasible on a portable 0.064 T MRI scanner. Joint relaxation distributions provide information beyond single-value relaxation mapping and may support further developments of quantitative multidimensional imaging at ultra-low field.
ER -