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Peer-reviewedCC BYClinical Case Reports

Utility of Metagenomic Next‐Generation Sequencing in Identifying Anaerobic Pathogens in a Pediatric Brain Abscess Secondary to Sinusitis: A Case Report

  • Risa Nagase1
  • Kunihiro Oba1
  • Mari Asakura1
  • Masashi Ogasawara1
  • Masahiro Noda1
  • Yusuke Yamada2
  • Asayo Furukawa3
  • Naoki Kojima4
  • Masanori Hashino5
  • Kazuhiro Horiba5
5 affiliations
  1. 1Department of Pediatrics Showa General Hospital Kodaira Japan
  2. 2Department of Neurosurgery Showa General Hospital Kodaira Japan
  3. 3Department of Otolaryngology Showa General Hospital Kodaira Japan
  4. 4Department of Critical Care and Emergency Medicine Showa General Hospital Kodaira Japan
  5. 5Laboratory of Microbial Genomics, Pathogen Genomics Center National Institute of Infectious Diseases, Japan Institute for Health Security Shinjuku‐ku Japan
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Abstract

In this pediatric brain abscess case, metagenomic next‐generation sequencing (mNGS) identified an anaerobic bacterium that remained undetected using conventional culture methods, thus providing clinically relevant information for antimicrobial management. This indicates that mNGS may be a useful adjunct for optimizing treatment strategies.

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Cite

BibTeXRIS
BibTeX
@article{nagase2026utility,
  title = {{Utility of Metagenomic Next‐Generation Sequencing in Identifying Anaerobic Pathogens in a Pediatric Brain Abscess Secondary to Sinusitis: A Case Report}},
  author = {Risa Nagase and Kunihiro Oba and Mari Asakura and Masashi Ogasawara and Masahiro Noda and Yusuke Yamada and Asayo Furukawa and Naoki Kojima and Masanori Hashino and Kazuhiro Horiba},
  journal = {Clinical Case Reports},
  year = {2026},
  month = oct,
  doi = {10.1002/ccr3.73688},
  url = {https://doi.org/10.1002/ccr3.73688},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Utility of Metagenomic Next‐Generation Sequencing in Identifying Anaerobic Pathogens in a Pediatric Brain Abscess Secondary to Sinusitis: A Case Report
AU  - Risa Nagase
AU  - Kunihiro Oba
AU  - Mari Asakura
AU  - Masashi Ogasawara
AU  - Masahiro Noda
AU  - Yusuke Yamada
AU  - Asayo Furukawa
AU  - Naoki Kojima
AU  - Masanori Hashino
AU  - Kazuhiro Horiba
PY  - 2026
DA  - 2026/10/23
JO  - Clinical Case Reports
DO  - 10.1002/ccr3.73688
UR  - https://doi.org/10.1002/ccr3.73688
AB  - In this pediatric brain abscess case, metagenomic next‐generation sequencing (mNGS) identified an anaerobic bacterium that remained undetected using conventional culture methods, thus providing clinically relevant information for antimicrobial management. This indicates that mNGS may be a useful adjunct for optimizing treatment strategies.
SN  - 2050-0904
ER  -