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Peer-reviewedCC BYHippocampus

Phylogeny of Cortical‐Hippocampal Projections Reveals Selective Elimination of Input From Sensory Regions

  • Daniel Reznik1,2
  • Piotr Majka3
  • Marcello G. P. Rosa4
  • Menno P. Witter1,5
  • Christian F. Doeller1,5
5 affiliations
  1. 1Kavli Institute for Systems Neuroscience, Centre for Algorithms in the Cortex, NTNU Trondheim Norway
  2. 2Oxford Centre for Integrative Neuroimaging University of Oxford Oxford UK
  3. 3Laboratory of Neuroinformatics Nencki Institute of Experimental Biology of the Polish Academy of Sciences Warsaw Poland
  4. 4Department of Physiology and Neuroscience Program Biomedicine Discovery Institute, Monash University Melbourne Australia
  5. 5Kavli Institute for Systems Neuroscience, Norwegian Health Association Centre for Dementia Research, NTNU Trondheim Norway
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Abstract

The study of cross-species differences in the organization of the cerebral cortex received significant attention during the past century. However, the evolutionary principles governing changes in brain connectivity and their impact on cognition remain poorly understood. In the current study, we analyzed differences in anatomical input from the cerebral cortex to the hippocampal region across six species spanning more than 100 million years of mammalian evolution-the tenrec, rat, cat, marmoset, macaque and human. Our results demonstrate that, unlike direct transmodal cortical input, direct unimodal cortical input to the hippocampal region was selectively eliminated with the increase in brain size. Additionally, input from primary sensory regions was eliminated prior to input from non-primary sensory regions. Our findings suggest that hippocampus-related processes in different species operate on fundamentally different types of information, potentially underpinning cross-species differences in hippocampus-dependent cognition. Furthermore, our findings outline the evolutionary trajectory of the anatomical circuitry associating the human hippocampal region with the neocortex.

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Cite

BibTeXRIS
BibTeX
@article{reznik2026phylogeny,
  title = {{Phylogeny of Cortical‐Hippocampal Projections Reveals Selective Elimination of Input From Sensory Regions}},
  author = {Daniel Reznik and Piotr Majka and Marcello G. P. Rosa and Menno P. Witter and Christian F. Doeller},
  journal = {Hippocampus},
  year = {2026},
  month = sep,
  doi = {10.1002/hipo.70119},
  url = {https://doi.org/10.1002/hipo.70119},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Phylogeny of Cortical‐Hippocampal Projections Reveals Selective Elimination of Input From Sensory Regions
AU  - Daniel Reznik
AU  - Piotr Majka
AU  - Marcello G. P. Rosa
AU  - Menno P. Witter
AU  - Christian F. Doeller
PY  - 2026
DA  - 2026/09/01
JO  - Hippocampus
DO  - 10.1002/hipo.70119
UR  - https://doi.org/10.1002/hipo.70119
AB  - The study of cross-species differences in the organization of the cerebral cortex received significant attention during the past century. However, the evolutionary principles governing changes in brain connectivity and their impact on cognition remain poorly understood. In the current study, we analyzed differences in anatomical input from the cerebral cortex to the hippocampal region across six species spanning more than 100 million years of mammalian evolution-the tenrec, rat, cat, marmoset, macaque and human. Our results demonstrate that, unlike direct transmodal cortical input, direct unimodal cortical input to the hippocampal region was selectively eliminated with the increase in brain size. Additionally, input from primary sensory regions was eliminated prior to input from non-primary sensory regions. Our findings suggest that hippocampus-related processes in different species operate on fundamentally different types of information, potentially underpinning cross-species differences in hippocampus-dependent cognition. Furthermore, our findings outline the evolutionary trajectory of the anatomical circuitry associating the human hippocampal region with the neocortex.
SN  - 1050-9631
SN  - 1098-1063
ER  -