Advances in Research on Panax Ginseng-Derived EV-like Particles
- 1Jilin Ginseng Academy, Changchun University of Chinese Medicine, Changchun 130117, China
Abstract
Panax ginseng-derived EV-like particles (PG-EVLPs) are nanoscale lipid bilayer vesicles extracted from ginseng roots, stems, leaves, or cell cultures, with diameters typically between 50 and 200 nm. Available preclinical studies have demonstrated that PG-EVLPs exhibit favorable in vitro and in vivo biocompatibility and short-term safety, without obvious hemolysis, cytotoxicity or organ damage, making them an active area of research at the intersection of traditional Chinese medicine and nanomedicine. This review covers separation and purification methods, physicochemical characterization techniques, bioactive component composition, and pharmacological mechanisms of PG-EVLPs. It also evaluates several delivery strategies, including natural nanocarrier delivery, engineering modification, and hydrogel composite systems, and discusses current challenges in standardization, safety assessment, and clinical translation.
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BibTeX
@article{yan2026advances,
title = {{Advances in Research on Panax Ginseng-Derived EV-like Particles}},
author = {Qi Yan and Tianxia Sun and Enpeng Wang},
journal = {International Journal of Molecular Sciences},
year = {2026},
month = sep,
doi = {10.3390/ijms27188320},
url = {https://www.mdpi.com/1422-0067/27/18/8320},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Advances in Research on Panax Ginseng-Derived EV-like Particles
AU - Qi Yan
AU - Tianxia Sun
AU - Enpeng Wang
PY - 2026
DA - 2026/09/18
JO - International Journal of Molecular Sciences
DO - 10.3390/ijms27188320
UR - https://www.mdpi.com/1422-0067/27/18/8320
AB - Panax ginseng-derived EV-like particles (PG-EVLPs) are nanoscale lipid bilayer vesicles extracted from ginseng roots, stems, leaves, or cell cultures, with diameters typically between 50 and 200 nm. Available preclinical studies have demonstrated that PG-EVLPs exhibit favorable in vitro and in vivo biocompatibility and short-term safety, without obvious hemolysis, cytotoxicity or organ damage, making them an active area of research at the intersection of traditional Chinese medicine and nanomedicine. This review covers separation and purification methods, physicochemical characterization techniques, bioactive component composition, and pharmacological mechanisms of PG-EVLPs. It also evaluates several delivery strategies, including natural nanocarrier delivery, engineering modification, and hydrogel composite systems, and discusses current challenges in standardization, safety assessment, and clinical translation.
SN - 1422-0067
ER -