Atherosclerotic plaque injury-mediated murine thrombosis models: advantages and limitations
Abstract
In spite of current treatment strategies, myocardial infarction and stroke are still major causes of death worldwide. These events are triggered by damage of an atherosclerotic plaque, resulting in occlusive thrombus formation. Mouse studies have significantly contributed to our understanding of the mechanisms of atherogenesis and of thrombosis following plaque injury, but the extent to which the mouse serves as an accurate model of human disease is open to discussion. In this review, we provide a detailed overview and comparison of the described mouse models for atherothrombosis including their (dis)advantages. Herein guidance is provided on how to select a suitable atherothrombosis model for research questions primarily relevant to the field of thrombosis.
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BibTeX
@article{karel2026atherosclerotic,
title = {{Atherosclerotic plaque injury-mediated murine thrombosis models: advantages and limitations}},
author = {M Karel and Beatrice Hechler and M Kuijpers and J Cosemans},
journal = {Platelets},
year = {2026},
month = oct,
doi = {10.1080/09537104.2019.1708884},
url = {https://univoak.hal.science/hal-05255596v1},
note = {CC BY-NC-ND 4.0},
}
RIS
TY - JOUR
TI - Atherosclerotic plaque injury-mediated murine thrombosis models: advantages and limitations
AU - M Karel
AU - Beatrice Hechler
AU - M Kuijpers
AU - J Cosemans
PY - 2026
DA - 2026/10/14
JO - Platelets
DO - 10.1080/09537104.2019.1708884
UR - https://univoak.hal.science/hal-05255596v1
AB - In spite of current treatment strategies, myocardial infarction and stroke are still major causes of death worldwide. These events are triggered by damage of an atherosclerotic plaque, resulting in occlusive thrombus formation. Mouse studies have significantly contributed to our understanding of the mechanisms of atherogenesis and of thrombosis following plaque injury, but the extent to which the mouse serves as an accurate model of human disease is open to discussion. In this review, we provide a detailed overview and comparison of the described mouse models for atherothrombosis including their (dis)advantages. Herein guidance is provided on how to select a suitable atherothrombosis model for research questions primarily relevant to the field of thrombosis.
SN - 0953-7104
SN - 1369-1635
ER -