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Peer-reviewedCC BY 4.0Diagnostic Cytopathology

Low‐Grade Serous Carcinoma in Association With Endosalpingiosis in a Cervical Lymph Node: A Case Report and Literature Review

  • Nyein Nyein Htun1
  • Nour Sneige1
  1. 1Department of Pathology The University of Texas MD Anderson Cancer Center Houston Texas USA
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Abstract

Endosalpingiosis is a benign Müllerian inclusion that rarely involves supradiaphragmatic lymph nodes. Malignant transformation in the setting of nodal endosalpingiosis is exceptional. We report a case of low‐grade serous carcinoma arising in a cervical lymph node in the setting of endosalpingiosis in a 41‐year‐old woman presenting with Horner syndrome. Imaging revealed a densely calcified, hypermetabolic supraclavicular lymph node. Fine needle aspiration and core biopsy demonstrated tubal‐type epithelium consistent with endosalpingiosis adjacent to a neoplastic micropapillary and cribriform proliferation with psammoma bodies. Immunohistochemistry showed positive staining for PAX‐8, estrogen receptor, and WT1, supporting Müllerian origin. The patient had a remote history of serous borderline tumor with noninvasive implants and KRAS and MAPK1 mutations. No recurrent pelvic disease was identified on positron emission tomography–computed tomography. Neck dissection confirmed low‐grade serous carcinoma arising in association with nodal endosalpingiosis. This rare presentation underscores the importance of recognizing Müllerian proliferations in cervical nodes to avoid misdiagnosis as metastatic carcinoma.

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Cite

BibTeXRIS
BibTeX
@article{htun2026lowgrade,
  title = {{Low‐Grade Serous Carcinoma in Association With Endosalpingiosis in a Cervical Lymph Node: A Case Report and Literature Review}},
  author = {Nyein Nyein Htun and Nour Sneige},
  journal = {Diagnostic Cytopathology},
  year = {2026},
  month = sep,
  doi = {10.1002/dc.70206},
  url = {https://doi.org/10.1002/dc.70206},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Low‐Grade Serous Carcinoma in Association With Endosalpingiosis in a Cervical Lymph Node: A Case Report and Literature Review
AU  - Nyein Nyein Htun
AU  - Nour Sneige
PY  - 2026
DA  - 2026/09/01
JO  - Diagnostic Cytopathology
DO  - 10.1002/dc.70206
UR  - https://doi.org/10.1002/dc.70206
AB  - Endosalpingiosis is a benign Müllerian inclusion that rarely involves supradiaphragmatic lymph nodes. Malignant transformation in the setting of nodal endosalpingiosis is exceptional. We report a case of low‐grade serous carcinoma arising in a cervical lymph node in the setting of endosalpingiosis in a 41‐year‐old woman presenting with Horner syndrome. Imaging revealed a densely calcified, hypermetabolic supraclavicular lymph node. Fine needle aspiration and core biopsy demonstrated tubal‐type epithelium consistent with endosalpingiosis adjacent to a neoplastic micropapillary and cribriform proliferation with psammoma bodies. Immunohistochemistry showed positive staining for PAX‐8, estrogen receptor, and WT1, supporting Müllerian origin. The patient had a remote history of serous borderline tumor with noninvasive implants and KRAS and MAPK1 mutations. No recurrent pelvic disease was identified on positron emission tomography–computed tomography. Neck dissection confirmed low‐grade serous carcinoma arising in association with nodal endosalpingiosis. This rare presentation underscores the importance of recognizing Müllerian proliferations in cervical nodes to avoid misdiagnosis as metastatic carcinoma.
SN  - 8755-1039
SN  - 1097-0339
ER  -