Principal component analysis-derived magnetic resonance imaging brain fluid dynamics-related composite in the Alzheimer's spectrum.
- 1National Hospital for Geriatric Medicine National Center for Geriatrics and Gerontology Obu Aichi Japan.
- 2Department of Clinical and Experimental Neuroimaging Center for Development of Advanced Medicine for Dementia National Center for Geriatrics and Gerontology Obu Aichi Japan.
- 3Department of Innovative Biomedical Visualization (iBMV) Nagoya University Graduate School of Medicine Nagoya Aichi Japan.
Abstract
Magnetic resonance imaging (MRI) -derived markers may characterize complementary structural and diffusion-related features potentially relevant to brain fluid dynamics in Alzheimer's disease (AD). We developed an exploratory multivariate construct integrating these features and assessed clinical correlates. Fifty-six participants who were cognitively normal (CN) or had mild cognitive impairment or AD underwent MRI. Principal component analysis (PCA) integrated three complementary MRI measures: intracranial volume-adjusted choroid plexus volume, the diffusion tensor image analysis along the perivascular space (DTI-ALPS) index, and neurite orientation dispersion and density imaging-derived free-water-related isotropic volume fraction (FW/fISO). The first component was designated the PCA-derived MRI brain fluid dynamics-related composite (MRI-BFRC). The first component explained 58.4% of the variance, with higher scores reflecting larger choroid plexus volume, lower DTI-ALPS, and higher FW/fISO. In the primary multivariable model, clinically defined AD relative to CN and higher Fazekas total score were independently associated with higher MRI-BFRC. MRI-BFRC correlated strongly with ventricular volume (r = 0.779); after adjustment for brain and ventricular volumes, the association with Fazekas score remained significant, whereas the AD-CN association was attenuated. MRI-BFRC is an exploratory multimodal construct integrating MRI features selected for their potential relevance to brain fluid dynamics. Its strong coupling with ventricular enlargement indicates sensitivity to global structural variation; persistence of the white matter hyperintensity association after structural adjustment suggests variation not fully explained by global structural measures. MRI-BFRC may have potential as a multimodal imaging marker for evaluating brain fluid dynamics-related alterations, although validation against independent physiological measures is required.
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BibTeX
@article{yasuno2026principal,
title = {{Principal component analysis-derived magnetic resonance imaging brain fluid dynamics-related composite in the Alzheimer's spectrum.}},
author = {Fumihiko Yasuno and Toshiaki Taoka and Yasuyuki Kimura and Takashi Nihashi and Naoki Saji and Akinori Takeda and Takashi Sakurai and Takashi Kato},
journal = {Alzheimer's \& dementia (Amsterdam, Netherlands)},
year = {2026},
month = oct,
doi = {10.1002/dad2.70538},
url = {https://europepmc.org/article/MED/42996777},
note = {CC BY-NC},
}
RIS
TY - JOUR
TI - Principal component analysis-derived magnetic resonance imaging brain fluid dynamics-related composite in the Alzheimer's spectrum.
AU - Fumihiko Yasuno
AU - Toshiaki Taoka
AU - Yasuyuki Kimura
AU - Takashi Nihashi
AU - Naoki Saji
AU - Akinori Takeda
AU - Takashi Sakurai
AU - Takashi Kato
PY - 2026
DA - 2026/10/01
JO - Alzheimer's & dementia (Amsterdam, Netherlands)
DO - 10.1002/dad2.70538
UR - https://europepmc.org/article/MED/42996777
AB - Magnetic resonance imaging (MRI) -derived markers may characterize complementary structural and diffusion-related features potentially relevant to brain fluid dynamics in Alzheimer's disease (AD). We developed an exploratory multivariate construct integrating these features and assessed clinical correlates. Fifty-six participants who were cognitively normal (CN) or had mild cognitive impairment or AD underwent MRI. Principal component analysis (PCA) integrated three complementary MRI measures: intracranial volume-adjusted choroid plexus volume, the diffusion tensor image analysis along the perivascular space (DTI-ALPS) index, and neurite orientation dispersion and density imaging-derived free-water-related isotropic volume fraction (FW/fISO). The first component was designated the PCA-derived MRI brain fluid dynamics-related composite (MRI-BFRC). The first component explained 58.4% of the variance, with higher scores reflecting larger choroid plexus volume, lower DTI-ALPS, and higher FW/fISO. In the primary multivariable model, clinically defined AD relative to CN and higher Fazekas total score were independently associated with higher MRI-BFRC. MRI-BFRC correlated strongly with ventricular volume (r = 0.779); after adjustment for brain and ventricular volumes, the association with Fazekas score remained significant, whereas the AD-CN association was attenuated. MRI-BFRC is an exploratory multimodal construct integrating MRI features selected for their potential relevance to brain fluid dynamics. Its strong coupling with ventricular enlargement indicates sensitivity to global structural variation; persistence of the white matter hyperintensity association after structural adjustment suggests variation not fully explained by global structural measures. MRI-BFRC may have potential as a multimodal imaging marker for evaluating brain fluid dynamics-related alterations, although validation against independent physiological measures is required.
SN - 2352-8729
ER -