Peer-reviewedCC BYScientific Reports1 Jul 2026

Intrinsic capacity patterns and their association with early postoperative functional outcomes in older adults undergoing total knee arthroplasty

Ruixin Zhang¹
Jie Chen¹
Xueer Chen¹
Wei Huang¹
Shulin Zhang²

¹Department of Orthopaedic Surgery, Chongqing Municipal Health, Commission Key Laboratory of Musculoskeletal Regeneration and Translational Medicine, Orthopaedic Research Laboratory, The First Affiliated Hospital of Chongqing Medical University
²Department of Nursing, The First Affiliated Hospital of Chongqing Medical University

Abstract

This study aimed to identify latent classes of intrinsic capacity (IC) among older adults undergoing total knee arthroplasty (TKA) and to examine the association between IC patterns and short-term postoperative functional outcomes assessed by the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). Following the Integrated Care for Older People framework, IC was assessed across five domains—cognition, psychology, vitality, locomotion, and sensory function—using validated instruments. WOMAC scores were evaluated preoperatively and at 3 months postoperatively. Latent class analysis was performed to identify IC patterns, and multinomial logistic regression was used to examine factors associated with IC pattern classification. Three IC patterns were identified in older adults undergoing TKA: C1 “Low impairment” (59.34%), C2 “Vit + Psy” (10.75%), and C3 “Loc + Sen” (29.91%). Age, manual labour occupations, and use of walking assistive devices were significantly associated with IC pattern classification (all P < 0.05). After adjustment for baseline WOMAC and other covariates, no statistically significant differences were observed among IC pattern groups in WOMAC scores at 3 months postoperatively or ΔWOMAC (P > 0.05). Identification of IC patterns may enhance the understanding of multidimensional functional heterogeneity among older adults undergoing TKA and provide a potential framework for personalised perioperative assessment and future longitudinal research.

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Cite

BibTeX RIS

BibTeX

@article{zhang2026intrinsic,
  title = {{Intrinsic capacity patterns and their association with early postoperative functional outcomes in older adults undergoing total knee arthroplasty}},
  author = {Ruixin Zhang and Jie Chen and Xueer Chen and Wei Huang and Shulin Zhang},
  journal = {Scientific Reports},
  year = {2026},
  month = jul,
  doi = {10.1038/s41598-026-63184-w},
  url = {https://doi.org/10.1038/s41598-026-63184-w},
  note = {CC BY},
}

RIS

TY  - JOUR
TI  - Intrinsic capacity patterns and their association with early postoperative functional outcomes in older adults undergoing total knee arthroplasty
AU  - Ruixin Zhang
AU  - Jie Chen
AU  - Xueer Chen
AU  - Wei Huang
AU  - Shulin Zhang
PY  - 2026
DA  - 2026/07/01
JO  - Scientific Reports
DO  - 10.1038/s41598-026-63184-w
UR  - https://doi.org/10.1038/s41598-026-63184-w
AB  - This study aimed to identify latent classes of intrinsic capacity (IC) among older adults undergoing total knee arthroplasty (TKA) and to examine the association between IC patterns and short-term postoperative functional outcomes assessed by the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). Following the Integrated Care for Older People framework, IC was assessed across five domains—cognition, psychology, vitality, locomotion, and sensory function—using validated instruments. WOMAC scores were evaluated preoperatively and at 3 months postoperatively. Latent class analysis was performed to identify IC patterns, and multinomial logistic regression was used to examine factors associated with IC pattern classification. Three IC patterns were identified in older adults undergoing TKA: C1 “Low impairment” (59.34%), C2 “Vit + Psy” (10.75%), and C3 “Loc + Sen” (29.91%). Age, manual labour occupations, and use of walking assistive devices were significantly associated with IC pattern classification (all P < 0.05). After adjustment for baseline WOMAC and other covariates, no statistically significant differences were observed among IC pattern groups in WOMAC scores at 3 months postoperatively or ΔWOMAC (P > 0.05). Identification of IC patterns may enhance the understanding of multidimensional functional heterogeneity among older adults undergoing TKA and provide a potential framework for personalised perioperative assessment and future longitudinal research.
SN  - 2045-2322
ER  -

Abstract

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