Skip to content
DraconiticResearch
Search Sources API
194,161 studies31 sourcesUpdated 35 min ago
PreprintCC BYbioRxiv

A modelling challenge to improve preparedness for highly pathogenicavian influenza epidemics: objectives, design and synthetic datageneration

  1. 1Univ Toulouse, ENVT, INRAE

Abstract

Highly pathogenic avian influenza (HPAI) is among the most significant disease threats to poultry worldwide. Modelling challenges, where independent teams address a common epidemiological scenario, can support the development of response capabilities and strengthen communication between modellers and risk managers. Despite the established benefits of these exercises, they remain uncommon in animal health, and none have previously addressed avian influenza. Here Jolly Island, an artificial landscape of 9160 poultry farms with five production types, was developed and seeded with stochastic HPAI epidemics that ran their course over a three-to-four month period. From January through April 2026, 45 registered teams across five continents investigated a selected synthetic epidemic, producing probabilistic forecasts, inferring transmission drivers, and evaluating counterfactual control policies. Here the objectives, design choices, and data generation of the HPAI Modelling Challenge are described in full, covering transmission processes, surveillance system operations, and control strategy implementation, along with the selected epidemic trajectory, the narrative situation reports supplied to the teams at each phase, and the complete phase-specific datasets released to them. As the opening paper of this special issue, here is provided the foundation upon which all subsequent contributions, where teams document their approaches and analyses, are built.

Related

  1. From discovery to preparedness: reframing antimicrobial resistance as a global governance challenge
    Quan Khoi Nguyen, Jeffrey D. Mayne, Andrew W. Taylor-Robinson
    Frontiers in public healthPeer-reviewedCC BYFull textMicrobiologyEurope PMCCrossref
  2. Modelling vasopressin synthesis and storage dynamics during prolonged osmotic challenge and recovery based on activity dependent upregulation of mRNA transcription
    Duncan J. MacGregor
    PLOS Computational BiologyPeer-reviewedCC BY 4.0Full textNeurosciencePhysiologyPLOS
  3. Perceived face similarity reflects inverse-generative and naturalistic discriminative objectives
    Wenxuan Guo, Heiko H. Schütt, Kamila Maria Jozwik +3
    arXivPreprintarXiv licenceFull textNeurosciencearXiv
  4. Inferring the evolving objectives that organize animal behavior
    A. Jha, K. S. Shi, K. A. Fulton +5
    bioRxivPreprintCC BYFull textNeurosciencebioRxiv
  5. Simulating protein evolution with programmable fitness objectives derived from modern protein models
    K. Qiu, A. N. Lupas, S. Dunin-Horkawicz
    bioRxivPreprintCC BY-NC-NDFull textEvolutionary biologybioRxiv
BibTeX
@misc{hayes2026modelling,
  title = {{A modelling challenge to improve preparedness for highly pathogenicavian influenza epidemics: objectives, design and synthetic datageneration}},
  author = {B. H. Hayes and G. Beaunee and S. Lambert and C. Delecroix and T. Vergne},
  howpublished = {bioRxiv},
  year = {2026},
  month = oct,
  doi = {10.64898/2026.10.06.756671},
  url = {https://www.biorxiv.org/content/10.64898/2026.10.06.756671v1},
  note = {CC BY},
}
RIS
TY  - UNPB
TI  - A modelling challenge to improve preparedness for highly pathogenicavian influenza epidemics: objectives, design and synthetic datageneration
AU  - B. H. Hayes
AU  - G. Beaunee
AU  - S. Lambert
AU  - C. Delecroix
AU  - T. Vergne
PY  - 2026
DA  - 2026/10/06
PB  - bioRxiv
DO  - 10.64898/2026.10.06.756671
UR  - https://www.biorxiv.org/content/10.64898/2026.10.06.756671v1
AB  - Highly pathogenic avian influenza (HPAI) is among the most significant disease threats to poultry worldwide. Modelling challenges, where independent teams address a common epidemiological scenario, can support the development of response capabilities and strengthen communication between modellers and risk managers. Despite the established benefits of these exercises, they remain uncommon in animal health, and none have previously addressed avian influenza. Here Jolly Island, an artificial landscape of 9160 poultry farms with five production types, was developed and seeded with stochastic HPAI epidemics that ran their course over a three-to-four month period. From January through April 2026, 45 registered teams across five continents investigated a selected synthetic epidemic, producing probabilistic forecasts, inferring transmission drivers, and evaluating counterfactual control policies. Here the objectives, design choices, and data generation of the HPAI Modelling Challenge are described in full, covering transmission processes, surveillance system operations, and control strategy implementation, along with the selected epidemic trajectory, the narrative situation reports supplied to the teams at each phase, and the complete phase-specific datasets released to them. As the opening paper of this special issue, here is provided the foundation upon which all subsequent contributions, where teams document their approaches and analyses, are built.
ER  -