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Peer-reviewedCC BYJournal of materials chemistry‎ B

A multi-valent polymyxin-based fluorescent probe for the detection of Gram-negative infections

  • Richa Sharma
  • Maria Rodriguez-Rios
  • James Crossland
  • Maulida Septiyana
  • Alicia Megia-Fernandez
  • Maxime Klausen
  • Mark Bradley
Open at sourcePDFDOICite

Abstract

A multi-branched fluorogenic probe for the rapid and specific detection of Gram-negative bacteria is reported. Three Gram-negative-targeting azido-modified polymyxins were clicked onto a trivalent scaffold functionalised with the environmental green-emitting fluorophore 7-nitrobenz-2-oxa-1,3-diazole. The probe allowed wash-free detection of target bacteria with increased sensitivity and lower limits of detection compared to monovalent probes.

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Cite

BibTeXRIS
BibTeX
@article{sharma2026multivalent,
  title = {{A multi-valent polymyxin-based fluorescent probe for the detection of Gram-negative infections}},
  author = {Richa Sharma and Maria Rodriguez-Rios and James Crossland and Maulida Septiyana and Alicia Megia-Fernandez and Maxime Klausen and Mark Bradley},
  journal = {Journal of materials chemistry‎ B},
  year = {2026},
  month = sep,
  doi = {10.1039/d4tb01786b},
  url = {https://hal.science/hal-05747163v1},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - A multi-valent polymyxin-based fluorescent probe for the detection of Gram-negative infections
AU  - Richa Sharma
AU  - Maria Rodriguez-Rios
AU  - James Crossland
AU  - Maulida Septiyana
AU  - Alicia Megia-Fernandez
AU  - Maxime Klausen
AU  - Mark Bradley
PY  - 2026
DA  - 2026/09/11
JO  - Journal of materials chemistry‎ B
DO  - 10.1039/d4tb01786b
UR  - https://hal.science/hal-05747163v1
AB  - A multi-branched fluorogenic probe for the rapid and specific detection of Gram-negative bacteria is reported. Three Gram-negative-targeting azido-modified polymyxins were clicked onto a trivalent scaffold functionalised with the environmental green-emitting fluorophore 7-nitrobenz-2-oxa-1,3-diazole. The probe allowed wash-free detection of target bacteria with increased sensitivity and lower limits of detection compared to monovalent probes.
SN  - 2050-750X
ER  -