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Peer-reviewedCC BY-NC-ND 4.0npj Biofilms and Microbiomes

The gut microbiota-bone marrow axis: an emerging role in chemotherapy-induced myelosuppression

  • Li Gong1
  • Yeqi Wang1
  • Yongsheng Li2
  • Junli Huang1
  1. 1Key Laboratory of Biorheological Science and Technology of Ministry of Education, Bioengineering College, Chongqing University
  2. 2Department of Phase I Clinical Trial Ward, Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment, Chongqing University Cancer Hospital
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Abstract

Accumulating evidence indicates that gut microbiota extensively modulates the toxicity of chemotherapeutics. However, the role of microbiota in chemotherapy-induced myelosuppression (CIM) remains poorly characterized. This review synthesizes the pivotal role of gut microbiota in regulating hematopoiesis, summarizes recent findings on the links between gut microbiota and CIM, and discusses emerging strategies for alleviating CIM through microbiota modulation. Our analysis pinpoints key gaps and novel insights for targeted CIM therapies.

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Cite

BibTeXRIS
BibTeX
@article{gong2026microbiotabone,
  title = {{The gut microbiota-bone marrow axis: an emerging role in chemotherapy-induced myelosuppression}},
  author = {Li Gong and Yeqi Wang and Yongsheng Li and Junli Huang},
  journal = {npj Biofilms and Microbiomes},
  year = {2026},
  month = jul,
  doi = {10.1038/s41522-026-01080-x},
  url = {https://doi.org/10.1038/s41522-026-01080-x},
  note = {CC BY-NC-ND 4.0},
}
RIS
TY  - JOUR
TI  - The gut microbiota-bone marrow axis: an emerging role in chemotherapy-induced myelosuppression
AU  - Li Gong
AU  - Yeqi Wang
AU  - Yongsheng Li
AU  - Junli Huang
PY  - 2026
DA  - 2026/07/01
JO  - npj Biofilms and Microbiomes
DO  - 10.1038/s41522-026-01080-x
UR  - https://doi.org/10.1038/s41522-026-01080-x
AB  - Accumulating evidence indicates that gut microbiota extensively modulates the toxicity of chemotherapeutics. However, the role of microbiota in chemotherapy-induced myelosuppression (CIM) remains poorly characterized. This review synthesizes the pivotal role of gut microbiota in regulating hematopoiesis, summarizes recent findings on the links between gut microbiota and CIM, and discusses emerging strategies for alleviating CIM through microbiota modulation. Our analysis pinpoints key gaps and novel insights for targeted CIM therapies.
SN  - 2055-5008
ER  -