Age-related differences in clinical manifestations, neuroimaging features, and treatment of spontaneous intracranial hypotension: a retrospective cohort study.
5 affiliations
- 1Department of Neurology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
- 2Department of Neurology, the People's Hospital of Baiyun Distinct, Guangzhou, 510515, China.
- 3Department of Radiology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
- 4Department of Traditional Chinese Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
- 5Department of Neurology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China. [email protected].
Abstract
Background
The influence of age on the management of spontaneous intracranial hypotension (SIH), particularly epidural blood patch (EBP), remains unclear. This study aims to characterize age-related differences in clinical manifestation, neuroimaging features, and treatment outcomes.Methods
In this retrospective cohort study, we analyzed 54 SIH patients who underwent EBP at our center. Patients were classified into two groups based on the cohort median age (35 years). Demographic, clinical, neuroimaging features, and treatment outcomes were compared between the two groups. We further utilized Spearman correlation, locally weighted scatterplot smoothing, and multivariable linear regression to analyze the association between age and EBP volume. Several sensitivity analyses were conducted to assess the robustness of our findings.Results
Among 54 enrolled patients, the injected volume of EBP was markedly larger in the older group (26.00 [19.12, 32.75] vs. 19.25 [15.00, 24.00] ml, P = 0.018). While Spearman correlation indicated a significant positive correlation existed between age and EBP volume (ρ = 0.388, P = 0.004), subgroup analysis revealed a dissociation: a strong linear correlation in the older group (ρ = 0.458, P = 0.018) contrasted with a non-significant, non-monotonic trend in the younger group (ρ = -0.034, P = 0.863). Linear regression analysis showed that age was positively associated with EBP volume (β = 2.899, 95% confidence interval: 0.475-5.322, P = 0.023).Conclusion
These findings highlight the potential utility of considering patient age when planning EBP procedures, suggesting that age-adapted volume strategies may optimize treatment and warrant further investigation.
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BibTeX
@article{dong2026agerelated,
title = {{Age-related differences in clinical manifestations, neuroimaging features, and treatment of spontaneous intracranial hypotension: a retrospective cohort study.}},
author = {Xiaohang Dong and Qirui Liu and Sichen He and Guohui Huang and Wangdi Huang and Letao Zhang and Bin Chen and Wei Xie and Suyue Pan and Yabin Ji},
journal = {BMC neurology},
year = {2026},
month = jul,
doi = {10.1186/s12883-026-05186-9},
url = {https://europepmc.org/article/MED/42894118},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - Age-related differences in clinical manifestations, neuroimaging features, and treatment of spontaneous intracranial hypotension: a retrospective cohort study.
AU - Xiaohang Dong
AU - Qirui Liu
AU - Sichen He
AU - Guohui Huang
AU - Wangdi Huang
AU - Letao Zhang
AU - Bin Chen
AU - Wei Xie
AU - Suyue Pan
AU - Yabin Ji
PY - 2026
DA - 2026/07/01
JO - BMC neurology
DO - 10.1186/s12883-026-05186-9
UR - https://europepmc.org/article/MED/42894118
AB - Background The influence of age on the management of spontaneous intracranial hypotension (SIH), particularly epidural blood patch (EBP), remains unclear. This study aims to characterize age-related differences in clinical manifestation, neuroimaging features, and treatment outcomes.Methods In this retrospective cohort study, we analyzed 54 SIH patients who underwent EBP at our center. Patients were classified into two groups based on the cohort median age (35 years). Demographic, clinical, neuroimaging features, and treatment outcomes were compared between the two groups. We further utilized Spearman correlation, locally weighted scatterplot smoothing, and multivariable linear regression to analyze the association between age and EBP volume. Several sensitivity analyses were conducted to assess the robustness of our findings.Results Among 54 enrolled patients, the injected volume of EBP was markedly larger in the older group (26.00 [19.12, 32.75] vs. 19.25 [15.00, 24.00] ml, P = 0.018). While Spearman correlation indicated a significant positive correlation existed between age and EBP volume (ρ = 0.388, P = 0.004), subgroup analysis revealed a dissociation: a strong linear correlation in the older group (ρ = 0.458, P = 0.018) contrasted with a non-significant, non-monotonic trend in the younger group (ρ = -0.034, P = 0.863). Linear regression analysis showed that age was positively associated with EBP volume (β = 2.899, 95% confidence interval: 0.475-5.322, P = 0.023).Conclusion These findings highlight the potential utility of considering patient age when planning EBP procedures, suggesting that age-adapted volume strategies may optimize treatment and warrant further investigation.
SN - 1471-2377
ER -