A study on the correlation between serum anti-Müllerian hormone levels in male participants of pre-pregnancy genetic health checkup in Qingyang District, Chengdu City
- 1Department of Clinical Laboratory, Chengdu Qingyang District Maternal and Child Health Hospital
Abstract
Objective: To explore the relationship between serum anti-Müllerian hormone (AMH) levels and semen quality in men undergoing preconception health checkups.
Methods: A total of 145 male preconception patients were enrolled. Semen parameters, including sperm kinetics, were measured via computer-aided sperm analysis (CASA), and serum AMH levels were detected using chemiluminescence immunoassay. Spearman’s correlation and multivariate linear regression analyses were used for statistical analysis.
Results: A total of 145 men were included in the study. The median serum AMH level was 8.79 ng/ml, with an interquartile range of (5.25- 11.25) ng/mL. Spearman’s rank correlation analysis showed that serum AMH levels were positively correlated with total sperm count ( r = 0.268, P = 0.001), sperm concentration ( r = 0.219, P = 0.008), total PR count ( r = 0.225, P = 0.006), VCL ( r = 0.196, P = 0.018), VSL ( r = 0.179, P = 0.032), VAP ( r = 0.164, P = 0.049), and STR ( r = 0.165, P = 0.047). Multivariate linear regression analysis showed that after adjusting for confounding factors, such as age and abstinence days, serum AMH remained independently associated with total sperm count ( β = 0.549, P < 0.001), total PR count ( β = 0.584, P < 0.001), and VCL ( β = 0.572, P = 0.005).
Conclusion: Serum AMH levels in men showed weak but statistically significant positive correlations with total sperm count (r = 0.268), total PR count (r = 0.225), and selected sperm kinetic parameters (r = 0.164–0.196). After adjusting for confounders, AMH remained independently associated with total sperm count, total PR count, and VCL, although the overall explanatory power was limited. These findings suggest that serum AMH may have a limited role as an adjunctive biomarker in male fertility assessment; however, its clinical utility is uncertain, given the weak strength of the associations. Large-scale prospective studies are required to validate these findings and determine whether AMH provides incremental value beyond conventional semen analysis.
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BibTeX
@article{kou2026study,
title = {{A study on the correlation between serum anti-Müllerian hormone levels in male participants of pre-pregnancy genetic health checkup in Qingyang District, Chengdu City}},
author = {Huafang Kou and Chengyan Gui and Fang Liu and Xiangyue Sheng},
journal = {Frontiers in Endocrinology},
year = {2026},
month = oct,
doi = {10.3389/fendo.2026.1931330},
url = {https://www.frontiersin.org/articles/10.3389/fendo.2026.1931330/full},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - A study on the correlation between serum anti-Müllerian hormone levels in male participants of pre-pregnancy genetic health checkup in Qingyang District, Chengdu City
AU - Huafang Kou
AU - Chengyan Gui
AU - Fang Liu
AU - Xiangyue Sheng
PY - 2026
DA - 2026/10/27
JO - Frontiers in Endocrinology
DO - 10.3389/fendo.2026.1931330
UR - https://www.frontiersin.org/articles/10.3389/fendo.2026.1931330/full
AB - Objective: To explore the relationship between serum anti-Müllerian hormone (AMH) levels and semen quality in men undergoing preconception health checkups. Methods: A total of 145 male preconception patients were enrolled. Semen parameters, including sperm kinetics, were measured via computer-aided sperm analysis (CASA), and serum AMH levels were detected using chemiluminescence immunoassay. Spearman’s correlation and multivariate linear regression analyses were used for statistical analysis. Results: A total of 145 men were included in the study. The median serum AMH level was 8.79 ng/ml, with an interquartile range of (5.25- 11.25) ng/mL. Spearman’s rank correlation analysis showed that serum AMH levels were positively correlated with total sperm count ( r = 0.268, P = 0.001), sperm concentration ( r = 0.219, P = 0.008), total PR count ( r = 0.225, P = 0.006), VCL ( r = 0.196, P = 0.018), VSL ( r = 0.179, P = 0.032), VAP ( r = 0.164, P = 0.049), and STR ( r = 0.165, P = 0.047). Multivariate linear regression analysis showed that after adjusting for confounding factors, such as age and abstinence days, serum AMH remained independently associated with total sperm count ( β = 0.549, P < 0.001), total PR count ( β = 0.584, P < 0.001), and VCL ( β = 0.572, P = 0.005). Conclusion: Serum AMH levels in men showed weak but statistically significant positive correlations with total sperm count (r = 0.268), total PR count (r = 0.225), and selected sperm kinetic parameters (r = 0.164–0.196). After adjusting for confounders, AMH remained independently associated with total sperm count, total PR count, and VCL, although the overall explanatory power was limited. These findings suggest that serum AMH may have a limited role as an adjunctive biomarker in male fertility assessment; however, its clinical utility is uncertain, given the weak strength of the associations. Large-scale prospective studies are required to validate these findings and determine whether AMH provides incremental value beyond conventional semen analysis.
SN - 1664-2392
ER -