The efficacy and safety of endoscopic ultrasound selective variceal devascularization for the treatment of esophagogastric varices: a retrospective cohort study.
- 1Department of Gastroenterology, Affiliated Hospital of Nantong University, 20 Xisi Road, Nantong, Jiangsu, 226001, China.
- 2Department of Gastroenterology, The Second People's Hospital of Nantong, 298 Xinhua Road, Nantong, Jiangsu, 226001, China.
- 3Department of Gastroenterology, Affiliated Hospital of Nantong University, 20 Xisi Road, Nantong, Jiangsu, 226001, China. [email protected].
Abstract
Background
Gastroesophageal variceal bleeding is a life-threatening complication of portal hypertension. This study evaluated the efficacy and safety of endoscopic ultrasound-guided selective variceal devascularization (EUS-SVD) compared with conventional endoscopic cyanoacrylate injection.Methods
This retrospective cohort study adhered to the STROBE guidelines. Between August 2022 and June 2024, 107 patients were enrolled and allocated to conventional endoscopy (n = 52) or EUS-SVD (n = 55). Propensity score matching was performed to reduce confounding. Primary outcomes included rebleeding, ulcer formation, and resource utilization.Results
Compared with the conventional group, the EUS group required significantly lower volumes of polidocanol and cyanoacrylate (both P < 0.05). The 6‑month rebleeding rate and 3‑month ulcer formation rate were significantly lower in the EUS group (P < 0.05). Kaplan-Meier analysis demonstrated a reduced cumulative rebleeding incidence in the EUS group (HR 0.38, 95%CI 0.17-0.86, P = 0.021).Conclusions
Within the limitations of a single-center retrospective design, these findings suggest that EUS-SVD may represent a promising therapeutic option for gastroesophageal varices, although it requires validation in prospective randomized trials.
Related
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BibTeX
@article{guan2026efficacy,
title = {{The efficacy and safety of endoscopic ultrasound selective variceal devascularization for the treatment of esophagogastric varices: a retrospective cohort study.}},
author = {Chengqi Guan and Fan Huang and Hongyuan Shen and Wei Huang and Yachen Wang and Zhenbiao Mao and Cuihua Lu and Jian Feng Zhang},
journal = {BMC gastroenterology},
year = {2026},
month = jul,
doi = {10.1186/s12876-026-05151-3},
url = {https://europepmc.org/article/MED/42894121},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - The efficacy and safety of endoscopic ultrasound selective variceal devascularization for the treatment of esophagogastric varices: a retrospective cohort study.
AU - Chengqi Guan
AU - Fan Huang
AU - Hongyuan Shen
AU - Wei Huang
AU - Yachen Wang
AU - Zhenbiao Mao
AU - Cuihua Lu
AU - Jian Feng Zhang
PY - 2026
DA - 2026/07/01
JO - BMC gastroenterology
DO - 10.1186/s12876-026-05151-3
UR - https://europepmc.org/article/MED/42894121
AB - Background Gastroesophageal variceal bleeding is a life-threatening complication of portal hypertension. This study evaluated the efficacy and safety of endoscopic ultrasound-guided selective variceal devascularization (EUS-SVD) compared with conventional endoscopic cyanoacrylate injection.Methods This retrospective cohort study adhered to the STROBE guidelines. Between August 2022 and June 2024, 107 patients were enrolled and allocated to conventional endoscopy (n = 52) or EUS-SVD (n = 55). Propensity score matching was performed to reduce confounding. Primary outcomes included rebleeding, ulcer formation, and resource utilization.Results Compared with the conventional group, the EUS group required significantly lower volumes of polidocanol and cyanoacrylate (both P < 0.05). The 6‑month rebleeding rate and 3‑month ulcer formation rate were significantly lower in the EUS group (P < 0.05). Kaplan-Meier analysis demonstrated a reduced cumulative rebleeding incidence in the EUS group (HR 0.38, 95%CI 0.17-0.86, P = 0.021).Conclusions Within the limitations of a single-center retrospective design, these findings suggest that EUS-SVD may represent a promising therapeutic option for gastroesophageal varices, although it requires validation in prospective randomized trials.
SN - 1471-230X
ER -