The role of microbiota on thyroid cancer: from carcinogenicity, treatment and predictability
- 1Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital
- 2Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital
Abstract
In recent years, more and more attention has been paid to the mechanism of microbiota in thyroid cancer (TC). Gut microbiota (GM) and its metabolites can regulate the immune system and affect thyroid function through the gut-thyroid axis. When the GM is dysregulated, the intestinal barrier function is impaired, resulting in immune dysfunction, chronic inflammation, oncogene activation, and eventually leading to the occurrence of TC. In addition, intratumoral microbiota (ITM) is also directly involved in the occurrence, progression and invasion of TC. However, the mechanism of action between the microbiome and TC is still under exploration, and the research results in this field will have a major impact on disease cognition and clinical intervention. Chemotherapy, radiation, and immunotherapy are the main non-surgical treatments for TC. Furthermore, gut microbiota modulators, including probiotics and prebiotics, represent a potential therapeutic strategy for TC, offering new avenues for individualized treatment. In addition, the differences of microbiota in patients with TC can be used to predict tumor subtype, invasion, lymph node metastasis, and the efficacy of ¹³¹ I treatment. This review will integrate the existing research results to explore the role of microbiota in the occurrence, development, treatment and prediction of TC, so as to provide important reference for clinical research and treatment.
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BibTeX
@article{han2026role,
title = {{The role of microbiota on thyroid cancer: from carcinogenicity, treatment and predictability}},
author = {Jian-li Han and Xin-da Lu and Jia-jia Du},
journal = {Frontiers in Immunology},
year = {2026},
month = oct,
doi = {10.3389/fimmu.2026.1912576},
url = {https://www.frontiersin.org/articles/10.3389/fimmu.2026.1912576/full},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - The role of microbiota on thyroid cancer: from carcinogenicity, treatment and predictability
AU - Jian-li Han
AU - Xin-da Lu
AU - Jia-jia Du
PY - 2026
DA - 2026/10/05
JO - Frontiers in Immunology
DO - 10.3389/fimmu.2026.1912576
UR - https://www.frontiersin.org/articles/10.3389/fimmu.2026.1912576/full
AB - In recent years, more and more attention has been paid to the mechanism of microbiota in thyroid cancer (TC). Gut microbiota (GM) and its metabolites can regulate the immune system and affect thyroid function through the gut-thyroid axis. When the GM is dysregulated, the intestinal barrier function is impaired, resulting in immune dysfunction, chronic inflammation, oncogene activation, and eventually leading to the occurrence of TC. In addition, intratumoral microbiota (ITM) is also directly involved in the occurrence, progression and invasion of TC. However, the mechanism of action between the microbiome and TC is still under exploration, and the research results in this field will have a major impact on disease cognition and clinical intervention. Chemotherapy, radiation, and immunotherapy are the main non-surgical treatments for TC. Furthermore, gut microbiota modulators, including probiotics and prebiotics, represent a potential therapeutic strategy for TC, offering new avenues for individualized treatment. In addition, the differences of microbiota in patients with TC can be used to predict tumor subtype, invasion, lymph node metastasis, and the efficacy of ¹³¹ I treatment. This review will integrate the existing research results to explore the role of microbiota in the occurrence, development, treatment and prediction of TC, so as to provide important reference for clinical research and treatment.
SN - 1664-3224
ER -