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Peer-reviewedCC BYPLOS One

Compare 30-minute automated office blood pressure vs 24-hour ambulatory blood pressure monitoring: A prospective study

2 more authors
4 affiliations
  1. 1School of Medicine, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam.
  2. 2Department of Interventional Cardiology, University Medical Center Ho Chi Minh City, Ho Chi Minh City, Vietnam.
  3. 3Faculty of Public Health, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam.
  4. 4Department of Cardiology, University Medical Center Ho Chi Minh City, Ho Chi Minh City, Vietnam.

Abstract

Background: Ambulatory blood pressure monitoring (ABPM) is the reference standard for diagnosing hypertension (HTN), but its use in routine practice remains limited because of cost, availability, and patient burden. Automated office blood pressure (AOBP) has been proposed as a practical alternative, although its performance relative to ABPM remains uncertain. Objectives: To evaluate the agreement and diagnostic performance of 30-minute AOBP compared with 24-hour ABPM and to identify optimal cut-off values for detecting ambulatory hypertension. Methods: In this prospective cohort study, 79 adults undergoing ABPM also underwent 30-minute AOBP measurement with automated readings every 5 minutes. The mean of the final six measurements was analyzed. Agreement was assessed using paired comparisons and Bland–Altman analysis. Diagnostic performance using receiver operating characteristic (ROC) analysis and agreement statistics. Results: Thirty-minute AOBP values were consistently higher than ABPM measurements. Mean differences were +6.59/ + 7.27 mmHg for systolic/diastolic BP versus 24-hour ABPM and +3.73/ + 5.16 mmHg versus daytime ABPM (all p < 0.001). Bland–Altman analysis showed acceptable group-level agreement but wide limits of agreement. Sensitivity ranged from 84% to 96% and specificity from 28% to 79%. ROC analysis demonstrated good discrimination (AUC 0.77–0.87). The highest agreement with overall ABPM occurred at a cut-off of ≥140/84 mmHg (κ = 0.624). Conclusions: Thirty-minute AOBP showed good discrimination for elevated ambulatory blood pressure but systematically overestimated BP relative to ABPM. It may serve as a practical screening tool, although normal AOBP values cannot reliably exclude ambulatory HTN and confirmation with 24-hour ABPM remains necessary. Central Illustration: Diagnostic Performance of 30-Minute Automated Office Blood Pressure Compared With 24-Hour Ambulatory Monitoring

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BibTeX
@article{bui2026compare,
  title = {{Compare 30-minute automated office blood pressure vs 24-hour ambulatory blood pressure monitoring: A prospective study}},
  author = {Ai Cao My Bui and Quynh Tran Nhat Nguyen and Anh Ngoc Minh Bui and Minh Vu Phuc Ha and Nhan Phu Nguyen and Thy Ha Anh Nguyen and Nhan Quoc Dang and Phuong Minh Tran and Tu Vu Kha and Nhu Dong Phuong Nguyen and Liem Diep Bao Le and Huy Hoai Tran and Dung The Bui and Nghia Phu Nguyen},
  journal = {PLOS One},
  year = {2026},
  month = nov,
  doi = {10.1371/journal.pone.0360957},
  url = {https://doi.org/10.1371/journal.pone.0360957},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Compare 30-minute automated office blood pressure vs 24-hour ambulatory blood pressure monitoring: A prospective study
AU  - Ai Cao My Bui
AU  - Quynh Tran Nhat Nguyen
AU  - Anh Ngoc Minh Bui
AU  - Minh Vu Phuc Ha
AU  - Nhan Phu Nguyen
AU  - Thy Ha Anh Nguyen
AU  - Nhan Quoc Dang
AU  - Phuong Minh Tran
AU  - Tu Vu Kha
AU  - Nhu Dong Phuong Nguyen
AU  - Liem Diep Bao Le
AU  - Huy Hoai Tran
AU  - Dung The Bui
AU  - Nghia Phu Nguyen
PY  - 2026
DA  - 2026/11/02
JO  - PLOS One
DO  - 10.1371/journal.pone.0360957
UR  - https://doi.org/10.1371/journal.pone.0360957
AB  - Background: Ambulatory blood pressure monitoring (ABPM) is the reference standard for diagnosing hypertension (HTN), but its use in routine practice remains limited because of cost, availability, and patient burden. Automated office blood pressure (AOBP) has been proposed as a practical alternative, although its performance relative to ABPM remains uncertain. Objectives: To evaluate the agreement and diagnostic performance of 30-minute AOBP compared with 24-hour ABPM and to identify optimal cut-off values for detecting ambulatory hypertension. Methods: In this prospective cohort study, 79 adults undergoing ABPM also underwent 30-minute AOBP measurement with automated readings every 5 minutes. The mean of the final six measurements was analyzed. Agreement was assessed using paired comparisons and Bland–Altman analysis. Diagnostic performance using receiver operating characteristic (ROC) analysis and agreement statistics. Results: Thirty-minute AOBP values were consistently higher than ABPM measurements. Mean differences were +6.59/ + 7.27 mmHg for systolic/diastolic BP versus 24-hour ABPM and +3.73/ + 5.16 mmHg versus daytime ABPM (all p < 0.001). Bland–Altman analysis showed acceptable group-level agreement but wide limits of agreement. Sensitivity ranged from 84% to 96% and specificity from 28% to 79%. ROC analysis demonstrated good discrimination (AUC 0.77–0.87). The highest agreement with overall ABPM occurred at a cut-off of ≥140/84 mmHg (κ = 0.624). Conclusions: Thirty-minute AOBP showed good discrimination for elevated ambulatory blood pressure but systematically overestimated BP relative to ABPM. It may serve as a practical screening tool, although normal AOBP values cannot reliably exclude ambulatory HTN and confirmation with 24-hour ABPM remains necessary. Central Illustration: Diagnostic Performance of 30-Minute Automated Office Blood Pressure Compared With 24-Hour Ambulatory Monitoring
SN  - 1932-6203
ER  -