HPV18 DNA detection and pathological laryngopharyngeal reflux in a young woman with glottic squamous cell carcinoma in situ: a brief report.
- 1Otorhinolaryngology Hospital, The First Affiliated Hospital, Sun Yat-Sen University, 58# Zhongshan Road II, Guangzhou, 510080, China.
- 2Otorhinolaryngology Hospital, The First Affiliated Hospital, Sun Yat-Sen University, 58# Zhongshan Road II, Guangzhou, 510080, China. [email protected].
Abstract
Laryngeal cancer predominantly affects elderly males with long-term smoking and alcohol histories, and its occurrence in young females is extremely rare. We report a 26-year-old woman with glottic squamous cell carcinoma in situ who presented with persistent hoarseness. She had no history of smoking, alcohol use, or radiation exposure. Upon evaluation, high-risk HPV18 DNA was detected in FFPE tumor tissue by Lcn PCR, and 24-hour MII-pH monitoring indicated pathological laryngopharyngeal reflux. Targeted sequencing of 535 genes showed no driver mutations, tumor mutation burden elevation, or microsatellite instability. The patient underwent transoral laser resection followed by postoperative anti-reflux management. At follow-up, she remained recurrence-free. This case suggests a possible contribution of HPV18 and laryngopharyngeal reflux to carcinogenesis in a young non-smoking woman with glottic carcinoma in situ. The findings support selective virologic evaluation and individualized reflux assessment in clinically atypical laryngeal squamous lesions.
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BibTeX
@article{liu2026hpv18,
title = {{HPV18 DNA detection and pathological laryngopharyngeal reflux in a young woman with glottic squamous cell carcinoma in situ: a brief report.}},
author = {Zhi Liu and Jinhong Zhang and Wenqing Chen and Jiaming Zheng and Thiansze Wong and Wenbin Lei and Kexing Lyu},
journal = {Infectious agents and cancer},
year = {2026},
month = jul,
doi = {10.1186/s13027-026-00783-2},
url = {https://europepmc.org/article/MED/42907848},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - HPV18 DNA detection and pathological laryngopharyngeal reflux in a young woman with glottic squamous cell carcinoma in situ: a brief report.
AU - Zhi Liu
AU - Jinhong Zhang
AU - Wenqing Chen
AU - Jiaming Zheng
AU - Thiansze Wong
AU - Wenbin Lei
AU - Kexing Lyu
PY - 2026
DA - 2026/07/01
JO - Infectious agents and cancer
DO - 10.1186/s13027-026-00783-2
UR - https://europepmc.org/article/MED/42907848
AB - Laryngeal cancer predominantly affects elderly males with long-term smoking and alcohol histories, and its occurrence in young females is extremely rare. We report a 26-year-old woman with glottic squamous cell carcinoma in situ who presented with persistent hoarseness. She had no history of smoking, alcohol use, or radiation exposure. Upon evaluation, high-risk HPV18 DNA was detected in FFPE tumor tissue by Lcn PCR, and 24-hour MII-pH monitoring indicated pathological laryngopharyngeal reflux. Targeted sequencing of 535 genes showed no driver mutations, tumor mutation burden elevation, or microsatellite instability. The patient underwent transoral laser resection followed by postoperative anti-reflux management. At follow-up, she remained recurrence-free. This case suggests a possible contribution of HPV18 and laryngopharyngeal reflux to carcinogenesis in a young non-smoking woman with glottic carcinoma in situ. The findings support selective virologic evaluation and individualized reflux assessment in clinically atypical laryngeal squamous lesions.
SN - 1750-9378
ER -