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Peer-reviewedCC BY 4.0Juntendo Medical Journal

Bedside Bioimpedance and Simple Functional Tests Identify Muscle Function Impairment Predicting Overall Survival in Chemotherapy-treated Metastatic Urothelial Carcinoma: A Retrospective Pilot Study

  • NOBUHITO MURAMOTO
  • KOSUKE KITAMURA
  • TOMOYA SHIRAKAWA
  • KAZUHIRO FUKUDA
  • AKIMASA KURE
  • TOSHIYUKI CHINA
  • HARUNA KAWANO
  • SHUJI ISOTANI
  • SATORU MUTO
  • HISAMITSU IDE
  • SHIGEO HORIE
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Abstract

Objectives: To evaluate whether bedside bioimpedance analysis and simple functional tests can identify muscle function impairment associated with overall survival in chemotherapy-treated metastatic urothelial carcinoma.

Materials: Retrospective single-center observational cohort study.

Methods: We reviewed 56 consecutive patients treated with systemic chemotherapy between January 2014 and February 2021. Skeletal muscle index was estimated using bioimpedance analysis. Handgrip strength and walking speed were assessed in routine care. Sarcopenia-related categories were defined using sex-specific Asian Working Group for Sarcopenia thresholds. The prespecified primary comparison was reference (normal plus pre-sarcopenia) versus muscle function impairment (dynapenia plus sarcopenia). Overall survival was evaluated using Kaplan-Meier analysis and Cox models with minimal age adjustment.

Results: Muscle function impairment was associated with shorter overall survival compared with the reference group. The association remained after age adjustment. Baseline characteristics suggested greater vulnerability in the impairment group, including lower body weight and serum albumin and higher inflammatory burden.

Conclusions: A pragmatic bedside phenotype based on bioimpedance analysis and simple functional testing may help identify chemotherapy-treated metastatic urothelial carcinoma patients at higher risk of poor survival.

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Cite

BibTeXRIS
BibTeX
@article{muramoto2026bedside,
  title = {{Bedside Bioimpedance and Simple Functional Tests Identify Muscle Function Impairment Predicting Overall Survival in Chemotherapy-treated Metastatic Urothelial Carcinoma: A Retrospective Pilot Study}},
  author = {NOBUHITO MURAMOTO and KOSUKE KITAMURA and TOMOYA SHIRAKAWA and KAZUHIRO FUKUDA and AKIMASA KURE and TOSHIYUKI CHINA and HARUNA KAWANO and SHUJI ISOTANI and SATORU MUTO and HISAMITSU IDE and SHIGEO HORIE},
  journal = {Juntendo Medical Journal},
  year = {2026},
  month = sep,
  url = {https://europepmc.org/article/MED/42973800},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Bedside Bioimpedance and Simple Functional Tests Identify Muscle Function Impairment Predicting Overall Survival in Chemotherapy-treated Metastatic Urothelial Carcinoma: A Retrospective Pilot Study
AU  - NOBUHITO MURAMOTO
AU  - KOSUKE KITAMURA
AU  - TOMOYA SHIRAKAWA
AU  - KAZUHIRO FUKUDA
AU  - AKIMASA KURE
AU  - TOSHIYUKI CHINA
AU  - HARUNA KAWANO
AU  - SHUJI ISOTANI
AU  - SATORU MUTO
AU  - HISAMITSU IDE
AU  - SHIGEO HORIE
PY  - 2026
DA  - 2026/09/01
JO  - Juntendo Medical Journal
UR  - https://europepmc.org/article/MED/42973800
AB  - Objectives: To evaluate whether bedside bioimpedance analysis and simple functional tests can identify muscle function impairment associated with overall survival in chemotherapy-treated metastatic urothelial carcinoma.  Materials: Retrospective single-center observational cohort study.  Methods: We reviewed 56 consecutive patients treated with systemic chemotherapy between January 2014 and February 2021. Skeletal muscle index was estimated using bioimpedance analysis. Handgrip strength and walking speed were assessed in routine care. Sarcopenia-related categories were defined using sex-specific Asian Working Group for Sarcopenia thresholds. The prespecified primary comparison was reference (normal plus pre-sarcopenia) versus muscle function impairment (dynapenia plus sarcopenia). Overall survival was evaluated using Kaplan-Meier analysis and Cox models with minimal age adjustment.  Results: Muscle function impairment was associated with shorter overall survival compared with the reference group. The association remained after age adjustment. Baseline characteristics suggested greater vulnerability in the impairment group, including lower body weight and serum albumin and higher inflammatory burden.  Conclusions: A pragmatic bedside phenotype based on bioimpedance analysis and simple functional testing may help identify chemotherapy-treated metastatic urothelial carcinoma patients at higher risk of poor survival.
SN  - 2759-7504
ER  -