Skip to content
DraconiticResearch
Search Sources API
203,203 studies31 sourcesUpdated 57 min ago
Peer-reviewedCC BY-NC-NDGland surgery

Impact of intraoperative retrograde transhepatic biliary drainage on clinically relevant postoperative pancreatic fistula following pancreaticoduodenectomy: a retrospective cohort study.

  • Kilhwan Kim1
  • Sanghyun Song1
  • Sungho Jo1
  1. 1Department of Surgery, Dankook University Hospital, Dankook University College of Medicine, Cheonan, Republic of Korea.
Read full textPDFDOICite

Abstract

Postoperative pancreatic fistula (POPF) remains a major complication after pancreaticoduodenectomy (PD). Retrograde transhepatic biliary drainage (RTBD) may provide external biliary decompression and reduce mechanical stress around the pancreaticojejunostomy, but its effect on clinically relevant POPF (CR-POPF) remains uncertain. To evaluate the association between perioperative external biliary decompression, primarily using RTBD, and CR-POPF after PD. We retrospectively analyzed 235 consecutive patients who underwent PD between October 2008 and December 2025. The drainage group included 90 patients with intraoperative RTBD and 41 with preoperative percutaneous transhepatic biliary drainage (PTBD) maintained perioperatively; 104 patients had no external biliary drainage. CR-POPF was defined according to the 2016 International Study Group of Pancreatic Surgery (ISGPS) criteria. Full-cohort multivariable analysis was primary, with propensity score matching (PSM) as a sensitivity analysis. CR-POPF occurred in 13 patients (9.9%) in the drainage group and 14 (13.5%) in the control group. External biliary decompression was not independently associated with CR-POPF [adjusted odds ratio (OR) =0.56; 95% confidence interval (CI): 0.23-1.35]. Soft pancreatic texture was independently associated with CR-POPF (adjusted OR =5.30; 95% CI: 1.15-24.50; P=0.03). After PSM, 93 patients remained in each group, with similar CR-POPF rates (10.8% vs. 12.9%). Perioperative external biliary decompression, primarily using RTBD, is not associated with a lower incidence of CR-POPF after PD.

Related

  1. Association between postoperative serum calcium and complications after pancreaticoduodenectomy in a retrospective multicenter study
    Tiantian Huang, Sicheng Pu, Wenyuan Xie +5
    Scientific ReportsPeer-reviewedCC BY-NC-ND 4.0Full textOncologyCrossref
  2. Omental wrapping combined with external pancreatic drainage is associated with a lower incidence of clinically relevant postoperative pancreatic fistula after pancreaticoduodenectomy: a retrospective study.
    Yihui Feng, Chunlong Shao, Shaoyan Xu +7
    Gland surgeryPeer-reviewedCC BY-NC-NDFull textOncologyEurope PMC
  3. Effect of intraoperative tranexamic acid use on postoperative bleeding in tumor replacement surgery : A retrospective cohort study
    Bahadır Balkanlı, Abdullah Kahraman, Serkan Bayram +1
    MedicinePeer-reviewedCC BYFull textGeneral medicineEurope PMC
  4. Association between intraoperative alactic base excess and postoperative acute kidney injury after liver transplantation: a retrospective cohort study
    D. Escarraman Martinez, S. Sanchez Diaz, K. I. Pedraza Yanez +6
    medRxivPreprintAll rights reservedFull textSurgery & anaesthesiamedRxiv
  5. Percutaneous transhepatic biliary drainage as an effective complementary treatment option for clinically relevant biliopancreatic, pancreatic and biliary leakage after pancreaticoduodenectomy
    Souheil Reda, Jon Unosson, Christopher Månsson +6
    BMC SurgeryPeer-reviewedCC BY 4.0Full textSurgery & anaesthesiaPMC

Cite

BibTeXRIS
BibTeX
@article{kim2026impact,
  title = {{Impact of intraoperative retrograde transhepatic biliary drainage on clinically relevant postoperative pancreatic fistula following pancreaticoduodenectomy: a retrospective cohort study.}},
  author = {Kilhwan Kim and Sanghyun Song and Sungho Jo},
  journal = {Gland surgery},
  year = {2026},
  month = sep,
  doi = {10.21037/gs-2026-0359},
  url = {https://europepmc.org/article/MED/42996855},
  note = {CC BY-NC-ND},
}
RIS
TY  - JOUR
TI  - Impact of intraoperative retrograde transhepatic biliary drainage on clinically relevant postoperative pancreatic fistula following pancreaticoduodenectomy: a retrospective cohort study.
AU  - Kilhwan Kim
AU  - Sanghyun Song
AU  - Sungho Jo
PY  - 2026
DA  - 2026/09/28
JO  - Gland surgery
DO  - 10.21037/gs-2026-0359
UR  - https://europepmc.org/article/MED/42996855
AB  - Postoperative pancreatic fistula (POPF) remains a major complication after pancreaticoduodenectomy (PD). Retrograde transhepatic biliary drainage (RTBD) may provide external biliary decompression and reduce mechanical stress around the pancreaticojejunostomy, but its effect on clinically relevant POPF (CR-POPF) remains uncertain. To evaluate the association between perioperative external biliary decompression, primarily using RTBD, and CR-POPF after PD. We retrospectively analyzed 235 consecutive patients who underwent PD between October 2008 and December 2025. The drainage group included 90 patients with intraoperative RTBD and 41 with preoperative percutaneous transhepatic biliary drainage (PTBD) maintained perioperatively; 104 patients had no external biliary drainage. CR-POPF was defined according to the 2016 International Study Group of Pancreatic Surgery (ISGPS) criteria. Full-cohort multivariable analysis was primary, with propensity score matching (PSM) as a sensitivity analysis. CR-POPF occurred in 13 patients (9.9%) in the drainage group and 14 (13.5%) in the control group. External biliary decompression was not independently associated with CR-POPF [adjusted odds ratio (OR) =0.56; 95% confidence interval (CI): 0.23-1.35]. Soft pancreatic texture was independently associated with CR-POPF (adjusted OR =5.30; 95% CI: 1.15-24.50; P=0.03). After PSM, 93 patients remained in each group, with similar CR-POPF rates (10.8% vs. 12.9%). Perioperative external biliary decompression, primarily using RTBD, is not associated with a lower incidence of CR-POPF after PD.
SN  - 2227-684X
SN  - 2227-8575
ER  -