Clinical value of calprotectin combined with urinary kidney injury molecule-1 for early prediction and prognostic assessment of acute kidney injury in patients with sepsis
Abstract
ObjectiveTo investigate the predictive value and prognostic assessment role of calprotectin （CP） combined with urinary kidney injury molecule-1 （KIM-1） for acute kidney injury （AKI） in patients with sepsis.MethodsA retrospective study enrolled 200 patients with sepsis treated at Beijing Friendship Hospital， Capital Medical University， from January 2022 to February 2025. Patients were divided into an AKI group （n=71） and a non-AKI group （n=129） according to whether AKI occurred during hospitalization. According to the AKI staging criteria， stage Ⅰ was defined as mild AKI （n=44）， while stages Ⅱ-Ⅲ were defined as severe AKI （n=27）. Based on 28-day outcomes in the AKI group， patients were further divided into a death group （n=21） and a survival group （n=50）. CP， KIM-1， acute physiology and chronic health evaluation Ⅱ （APACHE II）， and sequential organ failure assessment （SOFA） levels were compared among the groups. Receiver operating characteristic （ROC） curves were used to assess the area under the curve （AUC）， sensitivity， and specificity for CP， KIM-1， and the combined indicators in predicting AKI in patients with sepsis. Pearson analysis was used to evaluate correlations between CP， KIM-1 and APACHE Ⅱ/SOFA， and Spearman analysis was used to assess correlations between CP， KIM-1 and AKI stage. A Cox regression risk model was used to analyze the effect of CP and KIM-1 on 28-day prognosis in sepsis patients with AKI.ResultsCompared with the non-AKI group， the AKI group showed higher APACHE Ⅱ （16.17±4.09 vs 13.30±2.44） and SOFA （5.42±1.46 vs 3.40±1.11） as well as higher serum CP （［150.55±26.07］ μg/L vs ［128.79±24.09］ μg/L） and urinary KIM-1 （［42.72±9.90］ ng/L vs ［33.76±10.64］ ng/L） （P<0.05）. Compared with the mild AKI group， the severe AKI group had higher serum CP （［159.67±31.40］ μg/L vs ［144.94±20.63］ μg/L）， urinary KIM-1 （［48.42±10.76］ ng/L vs ［39.22±7.52］ ng/L）， APACHE Ⅱ （18.04±4.83 vs 15.02±3.09）， and SOFA （6.22±1.50 vs 4.93±1.21） （P<0.05）. Compared with the survival group， the death group had higher CP （［169.52±27.84］ μg/L vs ［142.57±20.86］ μg/L） and KIM-1 （［48.09±8.70］ ng/L vs ［40.46±9.57］ ng/L） （P<0.05）， while there were no statistically significant differences between the two groups in APACHE Ⅱ and SOFA （P>0.05）. ROC curve analysis showed AUC values for CP， KIM-1， and the combined indicators in predicting AKI in patients with sepsis of 0.734， 0.754， and 0.872， respectively. Correlation analysis showed that CP and KIM-1 were positively correlated with APACHE Ⅱ score， SOFA score， and AKI stage （r=0.494， 0.325； sp=0.250， 0.459； P<0.05）. Cox regression risk analysis indicated that CP and KIM-1 were independent factors affecting 28-day prognosis in sepsis patients with AKI （P<0.05）.ConclusionCP and KIM-1 are abnormally elevated in sepsis patients with AKI， and their expression levels increase with the severity of AKI. Monitoring changes in CP and KIM-1 can help predict AKI in patients with sepsis， and the combined predictive performance of CP with KIM-1 is higher. This has positive significance for guiding the clinical prevention and treatment of AKI.
Related
- Development and Population-Based Prognostic Utility Assessment of an ICD-10-CM-Based Prediction Model to Identify Left Ventricular Systolic Dysfunction: Discrimination Performance and Population-Based Evaluation in 83,357 Patients with Acute Coronary Syndrome
- Proactive Prediction of Alarms in Hemodialysis Machines: A Comparative Evaluation of AI Models for Clinical Prognostic Support
- Deep-Learning-Based Assessment of Breast Arterial Calcification on Mammography: Technical Validation, Cardiovascular Prognostic Value, and Clinical Translation—A Narrative Review
- Circulating calprotectin and S100A8/A9-related biomarkers for diagnosis and prognostic stratification in adult acute infection and sepsis: a systematic review and meta-analysis.
- Non-Invasive Assessment of SMAD4 Expression Status in Pancreatic Ductal Adenocarcinoma: Diagnostic Value of T1ρ-Weighted Imaging Combined with Clinical Parameters
BibTeX
@article{yujie2026clinical,
title = {{Clinical value of calprotectin combined with urinary kidney injury molecule-1 for early prediction and prognostic assessment of acute kidney injury in patients with sepsis}},
author = {Lai Yu-jie and Liu Xia and Chen Jia and Qu Xiao-ling},
journal = {Linchuang shenzangbing zazhi},
year = {2026},
month = oct,
url = {http://www.lcszb.com/thesisDetails#10.3969/j.issn.1671-2390.2026.10.007},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - Clinical value of calprotectin combined with urinary kidney injury molecule-1 for early prediction and prognostic assessment of acute kidney injury in patients with sepsis
AU - Lai Yu-jie
AU - Liu Xia
AU - Chen Jia
AU - Qu Xiao-ling
PY - 2026
DA - 2026/10/24
JO - Linchuang shenzangbing zazhi
UR - http://www.lcszb.com/thesisDetails#10.3969/j.issn.1671-2390.2026.10.007
AB - ObjectiveTo investigate the predictive value and prognostic assessment role of calprotectin （CP） combined with urinary kidney injury molecule-1 （KIM-1） for acute kidney injury （AKI） in patients with sepsis.MethodsA retrospective study enrolled 200 patients with sepsis treated at Beijing Friendship Hospital， Capital Medical University， from January 2022 to February 2025. Patients were divided into an AKI group （n=71） and a non-AKI group （n=129） according to whether AKI occurred during hospitalization. According to the AKI staging criteria， stage Ⅰ was defined as mild AKI （n=44）， while stages Ⅱ-Ⅲ were defined as severe AKI （n=27）. Based on 28-day outcomes in the AKI group， patients were further divided into a death group （n=21） and a survival group （n=50）. CP， KIM-1， acute physiology and chronic health evaluation Ⅱ （APACHE II）， and sequential organ failure assessment （SOFA） levels were compared among the groups. Receiver operating characteristic （ROC） curves were used to assess the area under the curve （AUC）， sensitivity， and specificity for CP， KIM-1， and the combined indicators in predicting AKI in patients with sepsis. Pearson analysis was used to evaluate correlations between CP， KIM-1 and APACHE Ⅱ/SOFA， and Spearman analysis was used to assess correlations between CP， KIM-1 and AKI stage. A Cox regression risk model was used to analyze the effect of CP and KIM-1 on 28-day prognosis in sepsis patients with AKI.ResultsCompared with the non-AKI group， the AKI group showed higher APACHE Ⅱ （16.17±4.09 vs 13.30±2.44） and SOFA （5.42±1.46 vs 3.40±1.11） as well as higher serum CP （［150.55±26.07］ μg/L vs ［128.79±24.09］ μg/L） and urinary KIM-1 （［42.72±9.90］ ng/L vs ［33.76±10.64］ ng/L） （P<0.05）. Compared with the mild AKI group， the severe AKI group had higher serum CP （［159.67±31.40］ μg/L vs ［144.94±20.63］ μg/L）， urinary KIM-1 （［48.42±10.76］ ng/L vs ［39.22±7.52］ ng/L）， APACHE Ⅱ （18.04±4.83 vs 15.02±3.09）， and SOFA （6.22±1.50 vs 4.93±1.21） （P<0.05）. Compared with the survival group， the death group had higher CP （［169.52±27.84］ μg/L vs ［142.57±20.86］ μg/L） and KIM-1 （［48.09±8.70］ ng/L vs ［40.46±9.57］ ng/L） （P<0.05）， while there were no statistically significant differences between the two groups in APACHE Ⅱ and SOFA （P>0.05）. ROC curve analysis showed AUC values for CP， KIM-1， and the combined indicators in predicting AKI in patients with sepsis of 0.734， 0.754， and 0.872， respectively. Correlation analysis showed that CP and KIM-1 were positively correlated with APACHE Ⅱ score， SOFA score， and AKI stage （r=0.494， 0.325； sp=0.250， 0.459； P<0.05）. Cox regression risk analysis indicated that CP and KIM-1 were independent factors affecting 28-day prognosis in sepsis patients with AKI （P<0.05）.ConclusionCP and KIM-1 are abnormally elevated in sepsis patients with AKI， and their expression levels increase with the severity of AKI. Monitoring changes in CP and KIM-1 can help predict AKI in patients with sepsis， and the combined predictive performance of CP with KIM-1 is higher. This has positive significance for guiding the clinical prevention and treatment of AKI.
SN - 1671-2390
ER -