Skip to content
DraconiticResearch
Search Sources API
220,595 studies31 sourcesUpdated 27 min ago
Peer-reviewedCC BY-NC-ND 4.0BMC Cancer

CT- and MRI-detected calcification to predict 1p/19q codeletion status in gliomas: a systematic review and meta-analysis

  • José Joaquim Raposo-Neto1,2,3,4
  • Guilherme Cincinato de Almeida1
  • Isabela Milagres Guimarães1
  • Eduarda Lemes Dias1,5
  • Andrea de Martino Luppi1
  • Luciene C G Campos2,6
6 affiliations
  1. 1Radiology Division, School of Medicine, Clinics’ Hospital, Federal University of Uberlândia (UFU), Uberlândia, Minas Gerais Brazil
  2. 2Laboratory of Applied Pathology and Genetics, State University of Santa Cruz, Ilhéus, Bahia, 45662-900 Brazil
  3. 3Department of Health Science, State University of Santa Cruz, Ilhéus, Bahia, 45662-900 Brazil
  4. 4Department of Radiology and Imaging Diagnostics, Federal University of Uberlândia, Uberlândia, MG Brazil
  5. 5Federal University of Triângulo Mineiro (UFTM), Uberaba, Minas Gerais Brazil
  6. 6Department of Biological Science, State University of Santa Cruz, Ilhéus, Bahia, 45662- 900 Brazil
Read full textDOICite

Abstract

Background: Adult diffuse lower-grade gliomas (LGGs, WHO grades 2–3) are heterogeneous CNS tumors. The 1p/19q codeletion defines oligodendrogliomas (IDHmut-Codel) and predicts better prognosis. Noninvasive imaging biomarkers could aid preoperative tumor characterization, particularly when molecular testing is limited.

Purpose: To systematically evaluate the diagnostic performance of calcifications on CT and MRI as a predictor of 1p/19q codeletion status in gliomas.

Data sources: Seven electronic databases were systematically searched up to August 2025.

Study selection: Studies evaluating calcifications on CT or MRI for predicting 1p/19q codeletion status were included, with FISH, PCR, or NGS as reference standards. Ten studies comprising 1,256 patients met inclusion criteria.

Data analysis: Pooled sensitivity, specificity, diagnostic odds ratios (DOR), and hierarchical summary receiver operating characteristic area under the curve (HSROC-AUC) were calculated using bivariate random-effects meta-analysis.

Data synthesis: Calcifications showed pooled sensitivity of 0.45 (95% CI: 0.38–0.53) and specificity of 0.93 (95% CI: 0.88–0.95), with a DOR of 12.0 (95% CI: 6.41–22.46) and HSROC-AUC of 0.76 (95% CI: 0.46–0.94). The high specificity indicates that the presence of calcification strongly supports 1p/19q codeletion, whereas the lower sensitivity indicates that its absence should not be used to exclude codeletion.

Limitations: Heterogeneity was related to variations in imaging protocols and difficulties differentiating calcifications from hemorrhage or microbleeds across studies.

Conclusions: Calcifications on CT and MRI are a reliable noninvasive marker for identifying IDHmut-Codel gliomas and excluding IDHmut-Noncodel tumors. Their detection provides clinically relevant information for preoperative decision-making, particularly in resource-limited settings. Combining calcification assessment with other imaging features may further improve diagnostic accuracy.

Supplementary Information: The online version contains supplementary material available at https://doi.org/10.1186/s12885-026-16730-8.

Related

  1. Optimizing Immunohistochemical Surrogate Panels for 1p/19q Codeletion in IDH-Mutant Adult Diffuse Gliomas: Diagnostic Performance of Vimentin and H3K27me3
    Eliza M. Löckli, Rachael S. Ninan, Krisztina A. Chalupa +6
    CancersPeer-reviewedCC BY 4.0OncologyCrossref
  2. Diagnostic Accuracy of APTw and NOEw MRI Metrics for IDH Mutation and 1p/19q Codeletion Prediction in Gliomas
    Capucine Cadin, Stefano Casagranda, François Xavier Lejeune +13
    NMR in BiomedicinePeer-reviewedCC BY 4.0Full textHuman geneticsHAL
  3. A Case of Asymptomatic Carotid Artery Stenosis With Thumb‐Sized Calcification Detected on Panoramic Radiograph
    Kosei Shibata, Keiko Kaneko, Tatsuo Takaya +13
    Clinical case reportsPeer-reviewedCC BYFull textGeneral medicineEurope PMCPMCEurope PMC
  4. Focused Ultrasound-Mediated Blood–Brain Barrier Opening for Enhanced Drug Delivery in Diffuse Gliomas: A Systematic Review
    Gabriele Ciaffi, Renata Martinelli, Andrea Traverso +6
    BiomedicinesPeer-reviewedCC BYFull textGeneral medicineEurope PMC
  5. Beyond the cortex, early deficits, late recovery: a systematic review of language outcomes and subcortical mapping after awake craniotomy for diffuse gliomas
    Maher Nassor, Parsa Mousazadeh, Michaela Bramhall +4
    Chinese Neurosurgical JournalPeer-reviewedCC BY 4.0Full textOncologyPMC

Cite

BibTeXRIS
BibTeX
@article{raposoneto2026mridetected,
  title = {{CT- and MRI-detected calcification to predict 1p/19q codeletion status in gliomas: a systematic review and meta-analysis}},
  author = {José Joaquim Raposo-Neto and Guilherme Cincinato de Almeida and Isabela Milagres Guimarães and Eduarda Lemes Dias and Andrea de Martino Luppi and Luciene C G Campos},
  journal = {BMC Cancer},
  year = {2026},
  month = aug,
  doi = {10.1186/s12885-026-16730-8},
  url = {https://doi.org/10.1186/s12885-026-16730-8},
  note = {CC BY-NC-ND 4.0},
}
RIS
TY  - JOUR
TI  - CT- and MRI-detected calcification to predict 1p/19q codeletion status in gliomas: a systematic review and meta-analysis
AU  - José Joaquim Raposo-Neto
AU  - Guilherme Cincinato de Almeida
AU  - Isabela Milagres Guimarães
AU  - Eduarda Lemes Dias
AU  - Andrea de Martino Luppi
AU  - Luciene C G Campos
PY  - 2026
DA  - 2026/08/12
JO  - BMC Cancer
DO  - 10.1186/s12885-026-16730-8
UR  - https://doi.org/10.1186/s12885-026-16730-8
AB  - Background: Adult diffuse lower-grade gliomas (LGGs, WHO grades 2–3) are heterogeneous CNS tumors. The 1p/19q codeletion defines oligodendrogliomas (IDHmut-Codel) and predicts better prognosis. Noninvasive imaging biomarkers could aid preoperative tumor characterization, particularly when molecular testing is limited.  Purpose: To systematically evaluate the diagnostic performance of calcifications on CT and MRI as a predictor of 1p/19q codeletion status in gliomas.  Data sources: Seven electronic databases were systematically searched up to August 2025.  Study selection: Studies evaluating calcifications on CT or MRI for predicting 1p/19q codeletion status were included, with FISH, PCR, or NGS as reference standards. Ten studies comprising 1,256 patients met inclusion criteria.  Data analysis: Pooled sensitivity, specificity, diagnostic odds ratios (DOR), and hierarchical summary receiver operating characteristic area under the curve (HSROC-AUC) were calculated using bivariate random-effects meta-analysis.  Data synthesis: Calcifications showed pooled sensitivity of 0.45 (95% CI: 0.38–0.53) and specificity of 0.93 (95% CI: 0.88–0.95), with a DOR of 12.0 (95% CI: 6.41–22.46) and HSROC-AUC of 0.76 (95% CI: 0.46–0.94). The high specificity indicates that the presence of calcification strongly supports 1p/19q codeletion, whereas the lower sensitivity indicates that its absence should not be used to exclude codeletion.  Limitations: Heterogeneity was related to variations in imaging protocols and difficulties differentiating calcifications from hemorrhage or microbleeds across studies.  Conclusions: Calcifications on CT and MRI are a reliable noninvasive marker for identifying IDHmut-Codel gliomas and excluding IDHmut-Noncodel tumors. Their detection provides clinically relevant information for preoperative decision-making, particularly in resource-limited settings. Combining calcification assessment with other imaging features may further improve diagnostic accuracy.  Supplementary Information: The online version contains supplementary material available at https://doi.org/10.1186/s12885-026-16730-8.
SN  - 1471-2407
ER  -