Perioperative ASL-derived CBF changes are associated with complications after Moyamoya bypass surgery.
- 1Department of Neurosurgery, Guangxi Medical University Cancer Hospital, Nanning, China.
- 2Department of Neurosurgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Abstract
Background
Postoperative hyperperfusion and insufficient perfusion augmentation are important contributors to morbidity after revascularization surgery for Moyamoya disease (MMD). Arterial spin labeling (ASL) enables noninvasive assessment of cerebral blood flow (CBF), but the relationship between perioperative ASL-derived CBF changes and specific postoperative complications after direct bypass remains incompletely defined. This study evaluated whether perioperative ASL-derived CBF changes were associated with postoperative complications after direct bypass surgery in patients with MMD.Methods
We retrospectively reviewed 146 patients with MMD who underwent first-time direct bypass surgery between June 2020 and October 2024. Preoperative ASL and a standardized postoperative ASL examination on postoperative day 5 were performed, and CBF values were measured in the recipient vascular territory. Subsequent intracranial hemorrhage, cerebral infarction, and postoperative seizures occurring within 90 days after surgery were analyzed. Firth penalized logistic regression was used for the hemorrhage outcome, conventional logistic regression was used for cerebral infarction, and ROC analyses included bootstrap assessment of cutoff uncertainty and 0.632 + bootstrap correction of AUC optimism.Results
Postoperative intracranial hemorrhage occurred in 8 patients (5.5%), cerebral infarction in 14 patients (9.6%), and postoperative seizures in 9 patients (6.2%); all events occurred after the day-5 ASL examination and within 90 days after surgery. ASL-derived CBF change was associated with postoperative intracranial hemorrhage in Firth penalized logistic regression (OR, 1.219; 95% profile-likelihood CI, 1.102-1.580; p < 0.001). The exploratory cutoff was >43.48 mL/100 g/min, with an apparent AUC of 0.9891 and a 0.632 + corrected AUC of 0.9890. ASL-derived CBF change was inversely associated with postoperative cerebral infarction (OR, 0.885; 95% CI, 0.839-0.933; p < 0.001). The exploratory cutoff was ≤4.48 mL/100 g/min, with an apparent AUC of 0.9150 and a 0.632 + corrected AUC of 0.9150. No significant association was observed between ASL-derived CBF change and postoperative seizures.Conclusion
Perioperative ASL-derived CBF change was associated with hemorrhagic and ischemic complications after direct bypass surgery for MMD. Marked postoperative CBF elevation was observed in patients with intracranial hemorrhage, whereas insufficient perfusion augmentation was associated with cerebral infarction. The proposed thresholds are exploratory, cohort-specific estimates and require external validation before clinical application.
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BibTeX
@article{lu2026perioperative,
title = {{Perioperative ASL-derived CBF changes are associated with complications after Moyamoya bypass surgery.}},
author = {Jiachao Lu and Chao Li and Tiansheng Su and Yong Mo and Guangxiang Huang and Shuling Tang and Ligen Mo and Chaojue Huang and Jun Yan},
journal = {Frontiers in neurology},
year = {2026},
month = oct,
doi = {10.3389/fneur.2026.1928443},
url = {https://europepmc.org/article/MED/42898159},
note = {CC BY},
}
RIS
TY - JOUR
TI - Perioperative ASL-derived CBF changes are associated with complications after Moyamoya bypass surgery.
AU - Jiachao Lu
AU - Chao Li
AU - Tiansheng Su
AU - Yong Mo
AU - Guangxiang Huang
AU - Shuling Tang
AU - Ligen Mo
AU - Chaojue Huang
AU - Jun Yan
PY - 2026
DA - 2026/10/05
JO - Frontiers in neurology
DO - 10.3389/fneur.2026.1928443
UR - https://europepmc.org/article/MED/42898159
AB - Background Postoperative hyperperfusion and insufficient perfusion augmentation are important contributors to morbidity after revascularization surgery for Moyamoya disease (MMD). Arterial spin labeling (ASL) enables noninvasive assessment of cerebral blood flow (CBF), but the relationship between perioperative ASL-derived CBF changes and specific postoperative complications after direct bypass remains incompletely defined. This study evaluated whether perioperative ASL-derived CBF changes were associated with postoperative complications after direct bypass surgery in patients with MMD.Methods We retrospectively reviewed 146 patients with MMD who underwent first-time direct bypass surgery between June 2020 and October 2024. Preoperative ASL and a standardized postoperative ASL examination on postoperative day 5 were performed, and CBF values were measured in the recipient vascular territory. Subsequent intracranial hemorrhage, cerebral infarction, and postoperative seizures occurring within 90 days after surgery were analyzed. Firth penalized logistic regression was used for the hemorrhage outcome, conventional logistic regression was used for cerebral infarction, and ROC analyses included bootstrap assessment of cutoff uncertainty and 0.632 + bootstrap correction of AUC optimism.Results Postoperative intracranial hemorrhage occurred in 8 patients (5.5%), cerebral infarction in 14 patients (9.6%), and postoperative seizures in 9 patients (6.2%); all events occurred after the day-5 ASL examination and within 90 days after surgery. ASL-derived CBF change was associated with postoperative intracranial hemorrhage in Firth penalized logistic regression (OR, 1.219; 95% profile-likelihood CI, 1.102-1.580; p < 0.001). The exploratory cutoff was >43.48 mL/100 g/min, with an apparent AUC of 0.9891 and a 0.632 + corrected AUC of 0.9890. ASL-derived CBF change was inversely associated with postoperative cerebral infarction (OR, 0.885; 95% CI, 0.839-0.933; p < 0.001). The exploratory cutoff was ≤4.48 mL/100 g/min, with an apparent AUC of 0.9150 and a 0.632 + corrected AUC of 0.9150. No significant association was observed between ASL-derived CBF change and postoperative seizures.Conclusion Perioperative ASL-derived CBF change was associated with hemorrhagic and ischemic complications after direct bypass surgery for MMD. Marked postoperative CBF elevation was observed in patients with intracranial hemorrhage, whereas insufficient perfusion augmentation was associated with cerebral infarction. The proposed thresholds are exploratory, cohort-specific estimates and require external validation before clinical application.
SN - 1664-2295
ER -