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PreprintCC BY-NC-NDChemRxiv

Modulation of Crystal Habit and Preferred Orientation of Aspirin: Combined Effects of Solvent and a Metallic Mesh Template during Evaporative Crystallization

  • Kelina Cyril Anthoni1,2
  • Divya S. Sujith1,2
  • Indumathi Sathisaran1,2
  1. 1Department of Bioscience and Engineering
  2. 2National Institute of Technology Calicut
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Abstract

Polymorphism plays a significant role in crystal engineering, as it can directly influence the physicochemical properties of active pharmaceutical ingredients (APIs). Aspirin (ASA) is one of the extensively studied model compounds in small-molecule polymorphism due to its pharmaceutical relevance. To date, ASA has been reported to exist in four polymorphic forms, Forms I, II, III, and IV. Like polymorphism, preferred (or preferential) orientation is another important characteristic in solidform screening that increases the risk of misidentifying pharmaceutical compounds as polymorphs. Here, we report evaporative crystallization of Form I ASA, with and without a metallic mesh template, in solvents of different polarities, exhibiting preferred orientation driven by the resulting crystal morphology 2 while retaining Form I. It was observed that the solvent and/or template independently/combinedly, along with grinding, has induced the preferred orientation of Form I ASA modulated by crystal habit during some crystallization conditions. Consequently, this study may provide a rationale for preventing the misidentification of crystal polymorphs during pharmaceutical manufacturing and development.

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Cite

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BibTeX
@misc{anthoni2026modulation,
  title = {{Modulation of Crystal Habit and Preferred Orientation of Aspirin: Combined Effects of Solvent and a Metallic Mesh Template during Evaporative Crystallization}},
  author = {Kelina Cyril Anthoni and Divya S. Sujith and Indumathi Sathisaran},
  howpublished = {ChemRxiv},
  year = {2026},
  month = sep,
  doi = {10.26434/chemrxiv.15009218/v1},
  url = {https://chemrxiv.org/doi/full/10.26434/chemrxiv.15009218/v1},
  note = {CC BY-NC-ND},
}
RIS
TY  - UNPB
TI  - Modulation of Crystal Habit and Preferred Orientation of Aspirin: Combined Effects of Solvent and a Metallic Mesh Template during Evaporative Crystallization
AU  - Kelina Cyril Anthoni
AU  - Divya S. Sujith
AU  - Indumathi Sathisaran
PY  - 2026
DA  - 2026/09/21
PB  - ChemRxiv
DO  - 10.26434/chemrxiv.15009218/v1
UR  - https://chemrxiv.org/doi/full/10.26434/chemrxiv.15009218/v1
AB  - Polymorphism plays a significant role in crystal engineering, as it can directly influence the physicochemical properties of active pharmaceutical ingredients (APIs). Aspirin (ASA) is one of the extensively studied model compounds in small-molecule polymorphism due to its pharmaceutical relevance. To date, ASA has been reported to exist in four polymorphic forms, Forms I, II, III, and IV. Like polymorphism, preferred (or preferential) orientation is another important characteristic in solidform screening that increases the risk of misidentifying pharmaceutical compounds as polymorphs. Here, we report evaporative crystallization of Form I ASA, with and without a metallic mesh template, in solvents of different polarities, exhibiting preferred orientation driven by the resulting crystal morphology 2 while retaining Form I. It was observed that the solvent and/or template independently/combinedly, along with grinding, has induced the preferred orientation of Form I ASA modulated by crystal habit during some crystallization conditions. Consequently, this study may provide a rationale for preventing the misidentification of crystal polymorphs during pharmaceutical manufacturing and development.
ER  -