Development of a Photocrosslinked Methacrylated Silk Fibroin Hydrogel Incorporating Hesperidin-Loaded Liposomes for Wound Dressing Applications.
- 1College of Animal Sciences & Technology, Zhejiang A&F University, Hangzhou 311300, China.
Abstract
Hesperidin (HES) is a natural flavonoid with antioxidant activity; however, its poor aqueous solubility and low bioavailability limit its biomedical applications. In this study, HES-loaded liposomes (HES-LPs) were prepared by thin-film hydration and incorporated into a methacrylated silk fibroin (SilMA) hydrogel to construct a photocrosslinked composite hydrogel for potential wound dressing applications. Successful methacrylation of SilMA was confirmed by ¹H nuclear magnetic resonance (¹H NMR) spectroscopy. HES-LPs exhibited a mean particle size of 87.13 ± 0.84 nm, a zeta potential of -3.80 ± 0.49 mV, an encapsulation efficiency of 72.48%, and a drug loading of 4.62%. The composite hydrogel exhibited good antioxidant activity in 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) assays. It also exhibited sustained HES release, good cytocompatibility, and enhanced L929 fibroblast migration. Overall, the composite hydrogel represents a candidate wound-dressing platform supported by preliminary in vitro evidence.
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BibTeX
@article{wang2026development,
title = {{Development of a Photocrosslinked Methacrylated Silk Fibroin Hydrogel Incorporating Hesperidin-Loaded Liposomes for Wound Dressing Applications.}},
author = {Di Wang and Jiahua Li and Yongxia Wang and Zhiyuan Bao and Wanfu Yue},
journal = {Gels (Basel, Switzerland)},
year = {2026},
month = oct,
doi = {10.3390/gels12100894},
url = {https://europepmc.org/article/MED/42929928},
note = {CC BY},
}
RIS
TY - JOUR
TI - Development of a Photocrosslinked Methacrylated Silk Fibroin Hydrogel Incorporating Hesperidin-Loaded Liposomes for Wound Dressing Applications.
AU - Di Wang
AU - Jiahua Li
AU - Yongxia Wang
AU - Zhiyuan Bao
AU - Wanfu Yue
PY - 2026
DA - 2026/10/02
JO - Gels (Basel, Switzerland)
DO - 10.3390/gels12100894
UR - https://europepmc.org/article/MED/42929928
AB - Hesperidin (HES) is a natural flavonoid with antioxidant activity; however, its poor aqueous solubility and low bioavailability limit its biomedical applications. In this study, HES-loaded liposomes (HES-LPs) were prepared by thin-film hydration and incorporated into a methacrylated silk fibroin (SilMA) hydrogel to construct a photocrosslinked composite hydrogel for potential wound dressing applications. Successful methacrylation of SilMA was confirmed by ¹H nuclear magnetic resonance (¹H NMR) spectroscopy. HES-LPs exhibited a mean particle size of 87.13 ± 0.84 nm, a zeta potential of -3.80 ± 0.49 mV, an encapsulation efficiency of 72.48%, and a drug loading of 4.62%. The composite hydrogel exhibited good antioxidant activity in 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) assays. It also exhibited sustained HES release, good cytocompatibility, and enhanced L929 fibroblast migration. Overall, the composite hydrogel represents a candidate wound-dressing platform supported by preliminary in vitro evidence.
SN - 2310-2861
ER -