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PreprintCC BYChemRxiv

Enhancing double-duplex invasion by using multiple parallel-stranded peptide nucleic acids

  • Masanari Shibata1,2
  • Kota Ito3,2
  • Osami Shoji3,2
  • Yuichiro Aiba3,2
  1. 1Research Center for Material Science
  2. 2Nagoya University
  3. 3Department of Chemistry, Graduate School of Science
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Abstract

Peptide nucleic acids (PNAs) enable sequence-specific recognition of double-stranded DNA (dsDNA) via invasion complex formation. Here, we report a strategy using multiple parallel-stranded PNAs to enhance invasion efficiency. Cooperative binding of PNAs at adjacent target sites markedly improved invasion efficiency and enabled sequence-specific recognition of plasmid DNA under physiological conditions.

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Cite

BibTeXRIS
BibTeX
@misc{shibata2026enhancing,
  title = {{Enhancing double-duplex invasion by using multiple parallel-stranded peptide nucleic acids}},
  author = {Masanari Shibata and Kota Ito and Osami Shoji and Yuichiro Aiba},
  howpublished = {ChemRxiv},
  year = {2026},
  month = oct,
  doi = {10.26434/chemrxiv.15010031/v1},
  url = {https://chemrxiv.org/doi/full/10.26434/chemrxiv.15010031/v1},
  note = {CC BY},
}
RIS
TY  - UNPB
TI  - Enhancing double-duplex invasion by using multiple parallel-stranded peptide nucleic acids
AU  - Masanari Shibata
AU  - Kota Ito
AU  - Osami Shoji
AU  - Yuichiro Aiba
PY  - 2026
DA  - 2026/10/07
PB  - ChemRxiv
DO  - 10.26434/chemrxiv.15010031/v1
UR  - https://chemrxiv.org/doi/full/10.26434/chemrxiv.15010031/v1
AB  - Peptide nucleic acids (PNAs) enable sequence-specific recognition of double-stranded DNA (dsDNA) via invasion complex formation. Here, we report a strategy using multiple parallel-stranded PNAs to enhance invasion efficiency. Cooperative binding of PNAs at adjacent target sites markedly improved invasion efficiency and enabled sequence-specific recognition of plasmid DNA under physiological conditions.
ER  -