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Peer-reviewedCC BY-NC-SA 4.0Annals of African Medicine

A Rare Case of Malignant Transformation in Bilateral Phyllodes Tumor Leading to Osteosarcomatous Metastases

  • Yogesh Langade1
  • Vaishali Singh1
  • Madhuri Singh2
  • Charusheela R. Gore2
  • Ronak Agarwal3
  1. 1Department of General Surgery, Dr. D. Y. Patil Medical College, Pune, Maharashtra, India
  2. 2Department of Pathology, Dr. D. Y. Patil Medical College, Pune, Maharashtra, India
  3. 3Department of Pulmonary Medicine, Dr. D. Y. Patil Medical College, Pune, Maharashtra, India
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Abstract

Phyllodes tumors are rare fibroepithelial neoplasms of the breast that typically exhibit benign or borderline behavior, with malignant transformation being an uncommon event. Even more exceptional is the occurrence of sarcomatous differentiation, particularly into osteosarcoma. We report the strikingly rare case of a 35-year-old female who initially presented with bilateral benign phyllodes tumors. Despite surgical excision and close follow-up, she developed a malignant transformation with osteosarcomatous features and widespread metastatic disease, including pulmonary and subcutaneous involvement. The aggressive course led to rapid clinical decline and ultimately, respiratory failure. This case underscores the unpredictable nature of phyllodes tumors and highlights the importance of vigilant, long-term monitoring – even in tumors initially diagnosed with benign. The transformation to an osteosarcomatous phenotype presents unique diagnostic and therapeutic challenges, reinforcing the need for a multidisciplinary approach and further research into tailored treatment options for such rare variants.

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Cite

BibTeXRIS
BibTeX
@article{langade2026rare,
  title = {{A Rare Case of Malignant Transformation in Bilateral Phyllodes Tumor Leading to Osteosarcomatous Metastases}},
  author = {Yogesh Langade and Vaishali Singh and Madhuri Singh and Charusheela R. Gore and Ronak Agarwal},
  journal = {Annals of African Medicine},
  year = {2026},
  month = jun,
  doi = {10.4103/aam.aam_8_26},
  url = {https://doi.org/10.4103/aam.aam_8_26},
  note = {CC BY-NC-SA 4.0},
}
RIS
TY  - JOUR
TI  - A Rare Case of Malignant Transformation in Bilateral Phyllodes Tumor Leading to Osteosarcomatous Metastases
AU  - Yogesh Langade
AU  - Vaishali Singh
AU  - Madhuri Singh
AU  - Charusheela R. Gore
AU  - Ronak Agarwal
PY  - 2026
DA  - 2026/06/03
JO  - Annals of African Medicine
DO  - 10.4103/aam.aam_8_26
UR  - https://doi.org/10.4103/aam.aam_8_26
AB  - Phyllodes tumors are rare fibroepithelial neoplasms of the breast that typically exhibit benign or borderline behavior, with malignant transformation being an uncommon event. Even more exceptional is the occurrence of sarcomatous differentiation, particularly into osteosarcoma. We report the strikingly rare case of a 35-year-old female who initially presented with bilateral benign phyllodes tumors. Despite surgical excision and close follow-up, she developed a malignant transformation with osteosarcomatous features and widespread metastatic disease, including pulmonary and subcutaneous involvement. The aggressive course led to rapid clinical decline and ultimately, respiratory failure. This case underscores the unpredictable nature of phyllodes tumors and highlights the importance of vigilant, long-term monitoring – even in tumors initially diagnosed with benign. The transformation to an osteosarcomatous phenotype presents unique diagnostic and therapeutic challenges, reinforcing the need for a multidisciplinary approach and further research into tailored treatment options for such rare variants.
SN  - 1596-3519
SN  - 0975-5764
ER  -