Stimuli-responsive vesicles in water-resistant nanofibers for molecular random access in DNA data storage
- 1CIC NanoGUNE BRTA Donostia-San Sebastián 20018 Spain
- 2University of the Basque Country, EHU Donostia-San Sebastián 20018 Spain
- 3IKERBASQUE, Basque Foundation for Science 48009 Bilbao Spain
Abstract
DNA is an attractive medium for data storage. Enabling efficient random access is essential for the practical use of DNA-based memory. We present a strategy for random access based on the selective release of target DNA from a nanofiber mesh matrix. Messages encoded in sets of DNA sequences are encapsulated inside stimuli-responsive small unilamellar vesicles (SUVs), embedded in an electrospun water-resistant nanofiber mesh. The target sequences are selectively released using orthogonal pH-based triggers. The orthogonality of these triggers enables the preservation of the SUVs containing the non-selected DNA, which remains in the fiber mesh for subsequent retrieval. This work combines sequence-independent chemical addressing with physical compartmentalization and double-layered protection. It represents initial steps towards a PCR-independent molecular selection system for random access in water-resistant fibers with potential applications in DNA-based memory architectures.
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BibTeX
@article{yereguielosua2026stimuliresponsive,
title = {{Stimuli-responsive vesicles in water-resistant nanofibers for molecular random access in DNA data storage}},
author = {Jokin Yeregui-Elosua and Diana Soukarie and Cecilia Wetzl and Alexander M. Bittner and Ibon Santiago},
journal = {Nanoscale Advances},
year = {2026},
month = sep,
doi = {10.1039/d6na00595k},
url = {https://doi.org/10.1039/d6na00595k},
note = {CC BY 3.0},
}
RIS
TY - JOUR
TI - Stimuli-responsive vesicles in water-resistant nanofibers for molecular random access in DNA data storage
AU - Jokin Yeregui-Elosua
AU - Diana Soukarie
AU - Cecilia Wetzl
AU - Alexander M. Bittner
AU - Ibon Santiago
PY - 2026
DA - 2026/09/21
JO - Nanoscale Advances
DO - 10.1039/d6na00595k
UR - https://doi.org/10.1039/d6na00595k
AB - DNA is an attractive medium for data storage. Enabling efficient random access is essential for the practical use of DNA-based memory. We present a strategy for random access based on the selective release of target DNA from a nanofiber mesh matrix. Messages encoded in sets of DNA sequences are encapsulated inside stimuli-responsive small unilamellar vesicles (SUVs), embedded in an electrospun water-resistant nanofiber mesh. The target sequences are selectively released using orthogonal pH-based triggers. The orthogonality of these triggers enables the preservation of the SUVs containing the non-selected DNA, which remains in the fiber mesh for subsequent retrieval. This work combines sequence-independent chemical addressing with physical compartmentalization and double-layered protection. It represents initial steps towards a PCR-independent molecular selection system for random access in water-resistant fibers with potential applications in DNA-based memory architectures.
SN - 2516-0230
ER -