Spatial analyses of infection and disease during chikungunya and Zika epidemics in Managua, Nicaragua
- 1University of California, Berkeley
Abstract
Chikungunya (CHIKV) and Zika (ZIKV) viruses have caused widespread epidemics across the Americas. After several years of minimal transmission, CHIKV is once again spreading in Nicaragua. We investigated spatial aspects of two chikungunya epidemics (2014, 2015) and one Zika epidemic (2016) in a prospective pediatric cohort in Nicaragua. We used generalized estimating equations, generalized additive and mixed-effects models, Kuldorffs scan statistic, and intracluster correlations to analyze the infection and disease status of [~]3,000 initially uninfected participants during each epidemic. We found that the incidence of infection (# new infections/total population) and disease (# new cases/total population) often had different spatial patterns, demonstrating that high-infection areas may not exhibit much disease. High infection incidence was observed near a large cemetery west of the study site. The large 2015 chikungunya epidemic and 2016 Zika epidemic started near the cemetery, exhibited high infection incidence throughout the study site, and had extensive month-to-month changes in spatiotemporal dynamics. Clusters of excess infections were large and adjacent to the cemetery, while clusters of excess uninfected participants were found in the northern and eastern sections of the study area. Notably, the intracluster correlation of infection was very weak in households ([~]0.2), and infection status was correlated across distances <200 meters. Similarities across the epidemics suggest that targeting interventions to the built, non-household environment may reduce epidemic potential in Managua. Overall, spatial analyses of epidemics that only use case data may substantially underestimate the full extent of viral transmission, missing identification of high-infection areas and opportunities for intervention.
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BibTeX
@misc{carrillo2026spatial,
title = {{Spatial analyses of infection and disease during chikungunya and Zika epidemics in Managua, Nicaragua}},
author = {F. Bustos Carrillo and B. Lopez Mercado and J. Carey Monterrey and D. Collado and T. Miranda and S. Saborio and S. Ojeda and N. Sanchez and M. Plazaola and H. Suazo Laguna and S. Arguello and H. Sturrock and A. Balmaseda and G. Kuan and E. Harris},
howpublished = {medRxiv},
year = {2026},
month = sep,
doi = {10.64898/2026.09.15.26363072},
url = {https://www.medrxiv.org/content/10.64898/2026.09.15.26363072v1},
note = {CC BY-NC-ND},
}
RIS
TY - UNPB
TI - Spatial analyses of infection and disease during chikungunya and Zika epidemics in Managua, Nicaragua
AU - F. Bustos Carrillo
AU - B. Lopez Mercado
AU - J. Carey Monterrey
AU - D. Collado
AU - T. Miranda
AU - S. Saborio
AU - S. Ojeda
AU - N. Sanchez
AU - M. Plazaola
AU - H. Suazo Laguna
AU - S. Arguello
AU - H. Sturrock
AU - A. Balmaseda
AU - G. Kuan
AU - E. Harris
PY - 2026
DA - 2026/09/15
PB - medRxiv
DO - 10.64898/2026.09.15.26363072
UR - https://www.medrxiv.org/content/10.64898/2026.09.15.26363072v1
AB - Chikungunya (CHIKV) and Zika (ZIKV) viruses have caused widespread epidemics across the Americas. After several years of minimal transmission, CHIKV is once again spreading in Nicaragua. We investigated spatial aspects of two chikungunya epidemics (2014, 2015) and one Zika epidemic (2016) in a prospective pediatric cohort in Nicaragua. We used generalized estimating equations, generalized additive and mixed-effects models, Kuldorffs scan statistic, and intracluster correlations to analyze the infection and disease status of [~]3,000 initially uninfected participants during each epidemic. We found that the incidence of infection (# new infections/total population) and disease (# new cases/total population) often had different spatial patterns, demonstrating that high-infection areas may not exhibit much disease. High infection incidence was observed near a large cemetery west of the study site. The large 2015 chikungunya epidemic and 2016 Zika epidemic started near the cemetery, exhibited high infection incidence throughout the study site, and had extensive month-to-month changes in spatiotemporal dynamics. Clusters of excess infections were large and adjacent to the cemetery, while clusters of excess uninfected participants were found in the northern and eastern sections of the study area. Notably, the intracluster correlation of infection was very weak in households ([~]0.2), and infection status was correlated across distances <200 meters. Similarities across the epidemics suggest that targeting interventions to the built, non-household environment may reduce epidemic potential in Managua. Overall, spatial analyses of epidemics that only use case data may substantially underestimate the full extent of viral transmission, missing identification of high-infection areas and opportunities for intervention.
ER -