Peer-reviewedCC BYAmerican journal of physiology. Heart and circulatory physiology
Pulmonary Hypertension Increases Left Ventricular Chamber Stiffness Through Ventricular Interdependence and Is Attenuated by Pulmonary-Targeted SERCA2a Gene Therapy
- 1Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York City, NY, USA
- 2Department of Medicine I, LMU University Hospital, Munich, Germany
Abstract
We found that right ventricular pressure overload from pulmonary hypertension significantly impairs left ventricular end-diastolic chamber stiffness. Gene therapy that attenuates progression of pulmonary hypertension also attenuated left ventricular chamber stiffening in a swine model. These findings suggest that adverse interventricular interactions may contribute to the worsening prognosis observed in patients with heart failure who develop pulmonary hypertension.
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BibTeX
@article{rideb2026pulmonary,
title = {{Pulmonary Hypertension Increases Left Ventricular Chamber Stiffness Through Ventricular Interdependence and Is Attenuated by Pulmonary-Targeted SERCA2a Gene Therapy}},
author = {Jernie Rideb and Olympia Bikou and Kenji Watanabe and Renata Mazurek and Samta Veera and Jaume Aguero and Kiyotake Ishikawa},
journal = {American journal of physiology. Heart and circulatory physiology},
year = {2026},
month = oct,
doi = {10.1152/ajpheart.90090.2026},
url = {https://doi.org/10.1152/ajpheart.90090.2026},
note = {CC BY},
}
RIS
TY - JOUR
TI - Pulmonary Hypertension Increases Left Ventricular Chamber Stiffness Through Ventricular Interdependence and Is Attenuated by Pulmonary-Targeted SERCA2a Gene Therapy
AU - Jernie Rideb
AU - Olympia Bikou
AU - Kenji Watanabe
AU - Renata Mazurek
AU - Samta Veera
AU - Jaume Aguero
AU - Kiyotake Ishikawa
PY - 2026
DA - 2026/10/07
JO - American journal of physiology. Heart and circulatory physiology
DO - 10.1152/ajpheart.90090.2026
UR - https://doi.org/10.1152/ajpheart.90090.2026
AB - We found that right ventricular pressure overload from pulmonary hypertension significantly impairs left ventricular end-diastolic chamber stiffness. Gene therapy that attenuates progression of pulmonary hypertension also attenuated left ventricular chamber stiffening in a swine model. These findings suggest that adverse interventricular interactions may contribute to the worsening prognosis observed in patients with heart failure who develop pulmonary hypertension.
SN - 0363-6135
SN - 1522-1539
ER -